Through the lens of phase separation: intrinsically unstructured protein and chromatin looping [0.03%]
透过凝聚态视角看组蛋白尾部和染色质环化
Ling Cai,Gang Greg Wang
Ling Cai
The establishment, maintenance and dynamic regulation of three-dimensional (3D) chromatin structures provide an important means for partitioning of genome into functionally distinctive domains, which helps to define specialized gene express...
Katharina S Keuenhof,Verena Kohler,Filomena Broeskamp et al.
Katharina S Keuenhof et al.
The nuclear pore complex (NPC) has long been assumed to be the sole route across the nuclear envelope, and under normal homeostatic conditions it is indeed the main mechanism of nucleo-cytoplasmic transport. However, it has also been known ...
The lamin A/C Ig-fold undergoes cell density-dependent changes that alter epitope binding [0.03%]
细胞密度依赖性变化改变表位结合影响结构域蛋白 lamin A/C Ig-折叠
Melanie Wallace,Gregory R Fedorchak,Richa Agrawal et al.
Melanie Wallace et al.
Lamins A/C are nuclear intermediate filament proteins that are involved in diverse cellular mechanical and biochemical functions. Here, we report that recognition of Lamins A/C by a commonly used antibody (JOL-2) that binds the Lamin A/C Ig...
Plant nuclear envelope as a hub connecting genome organization with regulation of gene expression [0.03%]
植物细胞核膜：连接基因组结构与基因表达调控的中心节点
Yu Tang
Yu Tang
Eukaryotic cells organize their genome within the nucleus with a double-layered membrane structure termed the nuclear envelope (NE) as the physical barrier. The NE not only shields the nuclear genome but also spatially separates transcripti...
Hui Zhang,Weihua Qin,Hector Romero et al.
Hui Zhang et al.
The eukaryotic nucleus displays a variety of membraneless compartments with distinct biomolecular composition and specific cellular activities. Emerging evidence indicates that protein-based liquid-liquid phase separation (LLPS) plays an es...
Kangjing Chen,Junjie Yuan,Youyang Sia et al.
Kangjing Chen et al.
PRR14 organizes H3K9me3-modified heterochromatin at the nuclear lamina [0.03%]
PRR14在核纤层组织H3K9me3修饰的异染色质
Anna A Kiseleva,Yu-Chia Cheng,Cheryl L Smith et al.
Anna A Kiseleva et al.
The eukaryotic genome is organized in three dimensions within the nucleus. Transcriptionally active chromatin is spatially separated from silent heterochromatin, a large fraction of which is located at the nuclear periphery. However, the me...
Amandine Barral,Jérôme Déjardin
Amandine Barral
Enhancers are cis-regulatory elements that can stimulate gene expression from distance, and drive precise spatiotemporal gene expression profiles during development. Functional enhancers display specific features including an open chromatin...
Nucleus-wide analysis of coherent RNA pol II movement in the context of chromatin dynamics in living cancer cells [0.03%]
活癌细胞中染色质动态变化背景下对RNA聚合酶II整体协调运动的分析
Haitham A Shaban
Haitham A Shaban
Activation of transcription results in coordinated movement of chromatin over a range of micrometers. To investigate how transcriptional regulation affects the mobility of RNA Pol II molecules and whether this movement response depends on t...
Aberrant chromatin organization at the nexus of laminopathy disease pathways [0.03%]
层纤毛病发病机制中的异常染色质组织结构问题
Garrett T Santini,Parisha P Shah,Ashley Karnay et al.
Garrett T Santini et al.