Recent advances in understanding the biological roles of the plant nuclear envelope [0.03%]
近期关于植物细胞核膜生物学功能研究的进展
Norman Reid Groves,Alecia Biel,Morgan Moser et al.
Norman Reid Groves et al.
The functional organization of the plant nuclear envelope is gaining increasing attention through new connections made between nuclear envelope-associated proteins and important plant biological processes. Animal nuclear envelope proteins p...
Automated 3D bio-imaging analysis of nuclear organization by NucleusJ 2.0 [0.03%]
利用NucleusJ 2.0进行自动三维生物影像分析以解析细胞核结构
Tristan Dubos,Axel Poulet,Céline Gonthier-Gueret et al.
Tristan Dubos et al.
NucleusJ 1.0, an ImageJ plugin, is a useful tool to analyze nuclear morphology and chromatin organization in plant and animal cells. NucleusJ 2.0 is a new release of NucleusJ, in which image processing is achieved more quickly using a comma...
Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies [0.03%]
核层蛋白的磷酸化：其在基因调控和层蛋白病发病机制中的新兴作用
Sunny Yang Liu,Kohta Ikegami
Sunny Yang Liu
Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery. Much less is known about unpolyme...
Reorganization of the nuclear architecture in the Drosophila melanogaster Lamin B mutant lacking the CaaX box [0.03%]
缺乏CaaX盒的黑腹果蝇Lamin B突变体中的核结构重组
Semen M Bondarenko,Igor V Sharakhov
Semen M Bondarenko
Lamins interact with the nuclear membrane and chromatin but the precise players and mechanisms of these interactions are unknown. Here, we tested whether the removal of the CaaX motif from Lamin B disrupts its attachment to the nuclear memb...
Impairment of nuclear F-actin formation and its relevance to cellular phenotypes in Hutchinson-Gilford progeria syndrome [0.03%]
核F肌动蛋白形成的损伤及其与Hutchinson-Gilford早老症的细胞表型的相关性
Yuto Takahashi,Shogo Hiratsuka,Nanako Machida et al.
Yuto Takahashi et al.
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation of lamin A, which contributes to nuclear architecture and the spatial organization of chromatin in the nucleus. The expression of a lamin A mutan...
Mechanical properties of nucleoprotein complexes determined by nanoindentation spectroscopy [0.03%]
纳米压痕光谱测定的核蛋白复合物力学性能
Tatini Rakshit,Daniël P Melters,Emilios K Dimitriadis et al.
Tatini Rakshit et al.
The interplay between transcription factors, chromatin remodelers, 3-D organization, and mechanical properties of the chromatin fiber controls genome function in eukaryotes. Besides the canonical histones which fold the bulk of the chromati...
Nuclear membrane ruptures, cell death, and tissue damage in the setting of nuclear lamin deficiencies [0.03%]
核纤层缺陷条件下的核膜破裂，细胞死亡和组织损伤
Natalie Y Chen,Paul H Kim,Loren G Fong et al.
Natalie Y Chen et al.
The nuclear membranes function as a barrier to separate the cell nucleus from the cytoplasm, but this barrier can be compromised by nuclear membrane ruptures, leading to intermixing of nuclear and cytoplasmic contents. Spontaneous nuclear m...
The ESCRT-III complex is required for nuclear pore complex sequestration and regulates gamete replicative lifespan in budding yeast meiosis [0.03%]
ESCRT-III复合物在酵母减数分裂中对于核孔复合物的隔离是必需的并且调节生殖细胞的繁殖寿命
Bailey A Koch,Elizabeth Staley,Hui Jin et al.
Bailey A Koch et al.
Cellular aging occurs as a cell loses its ability to maintain homeostasis. Aging cells eliminate damaged cellular compartments and other senescence factors via self-renewal. The mechanism that regulates cellular rejuvenation remains to be f...
Interplay of the nuclear envelope with chromatin in physiology and pathology [0.03%]
核膜与染色质在生理和病理中的相互作用
Romina Burla,Mattia La Torre,Klizia Maccaroni et al.
Romina Burla et al.
The nuclear envelope compartmentalizes chromatin in eukaryotic cells. The main nuclear envelope components are lamins that associate with a panoply of factors, including the LEM domain proteins. The nuclear envelope of mammalian cells opens...
Lamin microaggregates lead to altered mechanotransmission in progerin-expressing cells [0.03%]
表达progerin的细胞中核纤层蛋白微聚集体导致力学传导异常
Brooke E Danielsson,Katie V Tieu,Kranthidhar Bathula et al.
Brooke E Danielsson et al.
The nuclear lamina is a meshwork of intermediate filament proteins, and lamin A is the primary mechanical protein. An altered splicing of lamin A, known as progerin, causes the disease Hutchinson-Gilford progeria syndrome. Progerin-expressi...