Technical versus biological variability in a synthetic human gut community [0.03%]
合成人类肠道菌群中的技术变异性与生物变异性
Charlotte van de Velde,Clémence Joseph,Kenneth Simoens et al.
Charlotte van de Velde et al.
Synthetic communities grown in well-controlled conditions are an important tool to decipher the mechanisms driving community dynamics. However, replicate time series of synthetic human gut communities in chemostats are rare, and it is thus ...
Nayere Taebnia,Ute Römling,Volker M Lauschke
Nayere Taebnia
Enteric bacterial infections contribute substantially to global disease burden and mortality, particularly in the developing world. In vitro 2D monolayer cultures have provided critical insights into the fundamental virulence mechanisms of ...
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome [0.03%]
氨苄青霉素长期治疗的不同反应：微生物群的长期弹性与肠道耐药组的长期扰动
Achal Dhariwal,Lars Christian Haugli Bråten,Kjersti Sturød et al.
Achal Dhariwal et al.
The collateral impact of antibiotics on the microbiome has attained increasing attention. However, the ecological consequences of long-term antibiotic exposure on the gut microbiome, including antibiotic resistance, are still limited. Here,...
Multicenter Study
Gut microbes. 2023 Jan-Dec;15(1):2157200. DOI:10.1080/19490976.2022.2157200 2023
Gut microbiome signatures reflect different subtypes of irritable bowel syndrome [0.03%]
肠道菌群标志物反映不同亚型肠易激综合症
Qi Su,Hein M Tun,Qin Liu et al.
Qi Su et al.
Irritable bowel syndrome (IBS) is a heterogeneous condition with multifactorial pathogenesis. We studied deeply phenotyped individuals with microbiota sequencing enrolled in the American Gut Project. The IBS subjects were matched by age, ge...
Exogenous antibiotic resistance gene contributes to intestinal inflammation by modulating the gut microbiome and inflammatory cytokine responses in mouse [0.03%]
外源性抗生素抗性基因通过调节肠道微生物群和炎症细胞因子反应对小鼠肠炎有贡献
Rong Tan,Min Jin,Zhengshan Chen et al.
Rong Tan et al.
Dysregulation of the gut microbiota by environmental factors is associated with a variety of autoimmune and immune-mediated diseases. In addition, naturally-occurring extracellular antibiotic resistance genes (eARGs) might directly enter th...
Diet and the gut-lung axis in cystic fibrosis - direct & indirect links [0.03%]
囊性纤维化中的饮食和胃肠-肺轴的相关性——直接和间接联系
Isabelle McKay,Josie van Dorst,Tamarah Katz et al.
Isabelle McKay et al.
Cystic fibrosis (CF) is a multisystem, autosomal, recessive disease primarily affecting the lungs, pancreas, gastrointestinal tract, and liver. Whilst there is increasing evidence of a microbial 'gut-lung axis' in chronic respiratory condit...
Intratumor microbiome features reveal antitumor potentials of intrahepatic cholangiocarcinoma [0.03%]
瘤内微生物群特征揭示了肝内胆管癌的抗肿瘤潜力
Xiaoqiang Chai,Jie Wang,Huanping Li et al.
Xiaoqiang Chai et al.
Intrahepatic cholangiocarcinoma (ICC) is a rare malignancy with a high prevalence in China. This study aimed to characterize the ICC tissues' bacterial metagenomics signature and explore its antitumor potential for cancer. In this study, 16...
Integrative metagenomic and metabolomic analyses reveal gut microbiota-derived multiple hits connected to development of gestational diabetes mellitus in humans [0.03%]
综合性的人体妊娠糖尿病相关肠道菌群代谢组和基因组学分析研究
Dewei Ye,Jiating Huang,Jiaming Wu et al.
Dewei Ye et al.
Gestational diabetes mellitus (GDM) is characterized by the development of hyperglycemia and insulin resistance during the second or third trimester of pregnancy, associated with considerable risks to both the mother and developing fetus. A...
Non-caloric artificial sweeteners modulate conjugative transfer of multi-drug resistance plasmid in the gut microbiota [0.03%]
非热量人工甜味剂调节肠道微生物群中多重耐药质粒的接合转移
Zhigang Yu,Ian R Henderson,Jianhua Guo
Zhigang Yu
Non-caloric artificial sweeteners have been widely permitted as table sugar substitutes with high intensities of sweetness. They can pass through the intestinal tract without significant metabolization and frequently encounter the gut micro...
Gut microbiota differs between treatment outcomes early after fecal microbiota transplantation against recurrent Clostridioides difficile infection [0.03%]
粪便微生物移植早期复发性艰难梭状芽胞杆菌感染的治疗效果不同其肠道微生物也不同
Shaodong Wei,Martin Iain Bahl,Simon Mark Dahl Baunwall et al.
Shaodong Wei et al.
AbstarctIn fecal microbiota transplantation (FMT) against recurrent Clostridioides difficile infection (CDI), clinical outcomes are usually determined after 8 weeks. We hypothesized that the intestinal microbiota changes earlier than this t...
Randomized Controlled Trial
Gut microbes. 2022 Jan-Dec;14(1):2084306. DOI:10.1080/19490976.2022.2084306 2022