Gut-derived β-amyloid: Likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis [0.03%]
肠道衍生的β淀粉样蛋白：可能是参与阿尔茨海默病发病机制的肠-脑轴中的关键组成部分
Jinghua Jin,Zhi Xu,Lina Zhang et al.
Jinghua Jin et al.
Peripheral β-amyloid (Aβ), including those contained in the gut, may contribute to the formation of Aβ plaques in the brain, and gut microbiota appears to exert an impact on Alzheimer's disease (AD) via the gut-brain axis, although detai...
An IBD-associated pathobiont synergises with NSAID to promote colitis which is blocked by NLRP3 inflammasome and Caspase-8 inhibitors [0.03%]
与IBD相关的病原菌协同NSAID促进结肠炎的发展，该发展可被NLRP3炎症小体和Caspase-8抑制剂阻断
Raminder Singh,Valerio Rossini,Stephen R Stockdale et al.
Raminder Singh et al.
Conflicting evidence exists on the association between consumption of non-steroidal anti-inflammatory drugs (NSAIDs) and symptomatic worsening of inflammatory bowel disease (IBD). We hypothesized that the heterogeneous prevalence of pathobi...
Giada De Palma,David E Reed,Premysl Bercik
Giada De Palma
Visceral hypersensitivity, a fundamental mechanism of chronic visceral pain disorders, can result from both central or peripheral factors, or their combination. As an important regulator of normal gut function, the gut microbiota has been i...
The gut-microbiota-brain axis in a Spanish population in the aftermath of the COVID-19 pandemic: microbiota composition linked to anxiety, trauma, and depression profiles [0.03%]
COVID-19大流行之后西班牙人群中的肠道-微生物组-大脑轴：与焦虑、创伤和抑郁特征相关的微生物组成
Stefanie Malan-Müller,Mireia Valles-Colomer,Tomás Palomo et al.
Stefanie Malan-Müller et al.
The prevalence of anxiety and depression soared following the COVID-19 pandemic. To effectively treat these conditions, a comprehensive understanding of all etiological factors is needed. This study investigated fecal microbial features ass...
Micah J Worley
Micah J Worley
The major function of the mammalian immune system is to prevent and control infections caused by enteropathogens that collectively have altered human destiny. In fact, as the gastrointestinal tissues are the major interface of mammals with ...
Human milk oligosaccharides, antimicrobial drugs, and the gut microbiota of term neonates: observations from the KOALA birth cohort study [0.03%]
人类乳寡糖，抗菌药物和足月新生儿的肠道微生物群：来自KOALA队列研究的结果
D J M Barnett,M F Endika,C E Klostermann et al.
D J M Barnett et al.
The infant gut microbiota affects childhood health. This pioneer microbiota may be vulnerable to antibiotic exposures, but could be supported by prebiotic oligosaccharides found in breast milk and some infant formulas. We sought to characte...
Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides [0.03%]
莱克氏肠球菌产生的益生元外多糖对宿主代谢的益处
Junki Miyamoto,Hidenori Shimizu,Keiko Hisa et al.
Junki Miyamoto et al.
Fermented foods demonstrate remarkable health benefits owing to probiotic bacteria or microproducts produced via bacterial fermentation. Fermented foods are produced by the fermentative action of several lactic acid bacteria, including Leuc...
Pol32, an accessory subunit of DNA polymerase delta, plays an essential role in genome stability and pathogenesis of Candida albicans [0.03%]
Pol32，DNA聚合酶delta的辅助亚基，在白色念珠菌的基因组稳定性和致病性中起着至关重要的作用
Shraddheya Kumar Patel,Satya Ranjan Sahu,Bhabasha Gyanadeep Utkalaja et al.
Shraddheya Kumar Patel et al.
Candida albicans is a pathobiont that inflicts serious bloodstream fungal infections in individuals with compromised immunity and gut dysbiosis. Genomic diversity in the form of copy number alteration, ploidy variation, and loss of heterozy...
Technical versus biological variability in a synthetic human gut community [0.03%]
合成人类肠道菌群中的技术变异性与生物变异性
Charlotte van de Velde,Clémence Joseph,Kenneth Simoens et al.
Charlotte van de Velde et al.
Synthetic communities grown in well-controlled conditions are an important tool to decipher the mechanisms driving community dynamics. However, replicate time series of synthetic human gut communities in chemostats are rare, and it is thus ...
Nayere Taebnia,Ute Römling,Volker M Lauschke
Nayere Taebnia
Enteric bacterial infections contribute substantially to global disease burden and mortality, particularly in the developing world. In vitro 2D monolayer cultures have provided critical insights into the fundamental virulence mechanisms of ...