Microbiome and spatially resolved metabolomics analysis reveal the anticancer role of gut Akkermansia muciniphila by crosstalk with intratumoral microbiota and reprogramming tumoral metabolism in mice [0.03%]
微生物组和空间分辨代谢组分析揭示Akkermansia muciniphila通过与瘤内菌群对话及重编肿瘤代谢在小鼠体内发挥抗癌作用
Zhuxian Zhu,Jixu Cai,Weiwei Hou et al.
Zhuxian Zhu et al.
Although gut microbiota has been linked to cancer, little is known about the crosstalk between gut- and intratumoral-microbiomes. The goal of this study was to determine whether gut Akkermansia muciniphila (Akk) is involved in the regulatio...
Sarah Mansour,Tahreem Asrar,Wael Elhenawy
Sarah Mansour
The surge in inflammatory bowel diseases, like Crohn's disease (CD), is alarming. While the role of the gut microbiome in CD development is unresolved, the frequent isolation of adherent-invasive Escherichia coli (AIEC) strains from patient...
Gut microbiota alteration after cholecystectomy contributes to post-cholecystectomy diarrhea via bile acids stimulating colonic serotonin [0.03%]
胆囊切除术后肠道微生物群的变化通过胆汁酸刺激结肠血清素导致胆囊切除后腹泻
Yayun Xu,Jianfa Wang,Xubo Wu et al.
Yayun Xu et al.
Post-cholecystectomy diarrhea (PCD) is highly prevalent among outpatients with cholecystectomy, and gut microbiota alteration is correlated with it. However, how and to what extent changed fecal bacteria contributes to diarrhea are still un...
Microbial changes from bariatric surgery alters glucose-dependent insulinotropic polypeptide and prevents fatty liver disease [0.03%]
减肥手术引起肠道菌群变化可改变葡萄糖依赖性促胰岛素多肽并预防脂肪肝病
Tien S Dong,William Katzka,Julianne C Yang et al.
Tien S Dong et al.
Bariatric surgery remains a potent therapy for nonalcoholic fatty liver disease (NAFLD), but its inherent risk and eligibility requirement limit its adoption. Therefore, understanding how bariatric surgery improves NAFLD is paramount to dev...
Dysregulation of CD177+ neutrophils on intraepithelial lymphocytes exacerbates gut inflammation via decreasing microbiota-derived DMF [0.03%]
CD177+中性粒细胞通过减少肠道菌群来源的DMF对上皮内淋巴细胞失调导致肠道炎症加剧
Huimin Chen,Xiaohan Wu,Ruicong Sun et al.
Huimin Chen et al.
Neutrophils synergize with intestinal resident intraepithelial lymphocytes (IELs) to serve as the first-line defense and maintain intestinal homeostasis. However, the underlying mechanisms whereby neutrophils regulate IELs to inhibit intest...
Dynamic network modeling of gut microbiota during Alzheimer's disease progression in mice [0.03%]
小鼠阿尔茨海默病进展期间肠道微生物群的动态网络模型
Yinhu Li,Yijing Chen,Yingying Fan et al.
Yinhu Li et al.
The intimate association between the gut microbiota (GM) and the central nervous system points to potential intervention strategies for neurological diseases. Nevertheless, there is currently no theoretical framework for selecting the windo...
Fungal feelings in the irritable bowel syndrome: the intestinal mycobiome and abdominal pain [0.03%]
肠易激综合征的真菌感觉：肠道真菌群和腹痛
Iam van Thiel,Wj de Jonge,Rm van den Wijngaard
Iam van Thiel
Although the gut microbiota consists of bacteria, viruses, and fungi, most publications addressing the microbiota-gut-brain axis in irritable bowel syndrome (IBS) have a sole focus on bacteria. This may relate to the relatively low presence...
Candida albicans can foster gut dysbiosis and systemic inflammation during HIV infection [0.03%]
白色念珠菌可在HIV感染期间促进肠道菌群失调和全身性炎症反应
Silvere D Zaongo,Jing Ouyang,Stéphane Isnard et al.
Silvere D Zaongo et al.
Candida albicans (C. albicans) is a ubiquitous fungal commensal component of the human microbiota, and under certain circumstances, such as during an immunocompromised state, it may initiate different types of infection. Moreover, C. albica...
Acute appendicitis manifests as two microbiome state types with oral pathogens influencing severity [0.03%]
急性阑尾炎表现为两种微生物群状态类型，口腔病原体影响其严重程度
Marcus Blohs,Alexander Mahnert,Kevin Brunnader et al.
Marcus Blohs et al.
Mounting evidence suggests that acute appendicitis (AA) is not one but two diseases: complicated appendicitis, which is associated with necrosis leading to perforation or periappendicular abscess, and uncomplicated appendicitis, which does ...
Pathometagenomics reveals susceptibility to intestinal infection by Morganella to be mediated by the blood group-related B4galnt2 gene in wild mice [0.03%]
路徑元基因組學揭示了野鼠腸道感染morganella的易感性由與血型相關的B4galnt2基因介導
Marie Vallier,Abdulhadi Suwandi,Katrin Ehrhardt et al.
Marie Vallier et al.
Infectious disease is widely considered to be a major driver of evolution. A preponderance of signatures of balancing selection at blood group-related genes is thought to be driven by inherent trade-offs in susceptibility to disease. B4galn...