Michael W Dougherty,Christian Jobin
Michael W Dougherty
The etiology of colorectal cancer (CRC) is influenced by bacterial communities that colonize the gastrointestinal tract. These microorganisms derive essential nutrients from indigestible dietary or host-derived compounds and activate molecu...
Assembly of novel microbial genomes from gut metagenomes of rhesus macaque (Macaca mulatta) [0.03%]
恒河猴（Macaca mulatta）肠道元基因组中新型微生物基因组的组装
Shengzhi Yang,Zhenxin Fan,Jiawei Li et al.
Shengzhi Yang et al.
Rhesus macaque (RM, Macaca mulatta), as an important model animal, commonly suffers from chronic diarrheal disease, challenging the breeding of RMs. Gut microbiomes play key roles in maintaining intestinal health of RMs. However, it is stil...
Daniel Merenstein,Bruno Pot,Gregory Leyer et al.
Daniel Merenstein et al.
Probiotics are used for both generally healthy consumers and in clinical settings. However, theoretical and proven adverse events from probiotic consumption exist. New probiotic strains and products, as well as expanding use of probiotics i...
Tusha Sharma,Nagabhishek Sirpu Natesh,Ramesh Pothuraju et al.
Tusha Sharma et al.
The human gut microbiota can be potentially disrupted due to exposure of various environmental contaminants, including pesticides. These contaminants enter into non-target species in multiple ways and cause potential health risks. The gut m...
Shotgun Metagenomics of Gastric Biopsies Reveals Compositional and Functional Microbiome Shifts in High- and Low-Gastric-Cancer-Risk Populations from Colombia, South America [0.03%]
基于哥伦比亚南美洲高胃癌和低胃癌风险人群的胃活检样本宏基因组测序揭示了胃部微生物群组成的转变及功能变化
Anthony Mannion,Alexander Sheh,Zeli Shen et al.
Anthony Mannion et al.
Along with Helicobacter pylori infection, the gastric microbiota is hypothesized to modulate stomach cancer risk in susceptible individuals. Whole metagenomic shotgun sequencing (WMS) is a sequencing approach to characterize the microbiome ...
Microbiota-directed biotherapeutics: considerations for quality and functional assessment [0.03%]
微生态导向生物疗法：质量和功能评估的考量因素
Emily Ef Fekete,Daniel Figeys,Xu Zhang
Emily Ef Fekete
Mounting evidence points to causative or correlative roles of gut microbiome in the development of a myriad of diseases ranging from gastrointestinal diseases, metabolic diseases to neurological disorders and cancers. Consequently, efforts ...
Efficacy of Bifidobacterium longum alone or in multi-strain probiotic formulations during early life and beyond [0.03%]
婴儿期长双歧杆菌单独或联合其他菌株的益生菌制剂的效果研究及展望
Susan Mills,Bo Yang,Graeme J Smith et al.
Susan Mills et al.
The significance of Bifidobacterium to human health can be appreciated from its early colonization of the neonatal gut, where Bifidobacterium longum represents the most abundant species. While its relative abundance declines with age, it is...
Association of the gut microbiome with kidney function and damage in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL) [0.03%]
Hispanic社区健康研究/拉丁裔研究(HCHS/SOL)中肠道微生物与肾功能和损伤的关联性分析
Brandilyn A Peters,Qibin Qi,Mykhaylo Usyk et al.
Brandilyn A Peters et al.
Background: The gut microbiome is altered in chronic kidney disease (CKD), potentially contributing to CKD progression and co-morbidities, but population-based studies of the gut microbiome across a wide range of kidney f...
The role of the sex hormone-gut microbiome axis in tumor immunotherapy [0.03%]
性激素-肠道微生物轴在肿瘤免疫治疗中的作用
Luoyang Wang,Lei Tang,Dongchang Zhai et al.
Luoyang Wang et al.
Accumulating evidence suggested that both gut microbiome and sex play a critical role in the efficacy of immune checkpoint blockade therapy. Considering the reciprocal relationship between sex hormones and gut microbiome, the sex hormone-gu...
Bacterial flagellin is a dominant, stable innate immune activator in the gastrointestinal contents of mice and rats [0.03%]
细菌鞭毛蛋白是小鼠和大鼠胃肠内容物中主要的、稳定的固有免疫激活剂
Matam Vijay-Kumar,Venugopal R Bovilla,Beng San Yeoh et al.
Matam Vijay-Kumar et al.
Intestinal contents comprise the largest repository of immunogenic ligands of microbial origin. We undertook this study to assess the predominant microbe-associated molecular patterns (MAMPs) present therein and the receptors) that mediate ...