Shorter sleep time relates to lower human defensin 5 secretion and compositional disturbance of the intestinal microbiota accompanied by decreased short-chain fatty acid production [0.03%]
睡眠时间较短与人防御素5分泌减少、肠道菌群失调及短链脂肪酸产生降低有关
Yu Shimizu,Ryodai Yamamura,Yuki Yokoi et al.
Yu Shimizu et al.
Sleep is essential for our health. Short sleep is known to increase disease risks via imbalance of intestinal microbiota, dysbiosis. However, mechanisms by which short sleep induces dysbiosis remain unknown. Small intestinal Paneth cell reg...
Microbial metabolites as modulators of the infant gut microbiome and host-microbial interactions in early life [0.03%]
微生物代谢产物作为婴儿肠道菌群和宿主-微生物相互作用的调节因子在生命早期的作用
Henrik M Roager,Catherine Stanton,Lindsay J Hall
Henrik M Roager
The development of infant gut microbiome is a pivotal process affecting the ecology and function of the microbiome, as well as host health. While the establishment of the infant microbiome has been of interest for decades, the focus on gut ...
Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17/Treg balance and gut microbiota structure [0.03%]
乳糖乳杆菌GG通过调节卵形切除大鼠Th17/Treg平衡及肠道菌群结构改善骨质疏松症
Mengyu Guo,Huanjin Liu,Yinting Yu et al.
Mengyu Guo et al.
Background: With increasing knowledge about the gut - bone axis, more studies for treatments based on the regulation of postmenopausal osteoporosis by gut microbes are being conducted. Based on our previous work, this stu...
Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer [0.03%]
芽孢杆菌抗肿瘤作用在结直肠癌治疗中的潜力研究进展
Hui Xu,Haidan Luo,Jiayu Zhang et al.
Hui Xu et al.
Probiotic roles of Clostridium butyricum (C.B) are involved in regulating disease and cancers, yet the mechanistic basis for these regulatory roles remains largely unknown. Here, we demonstrate that C.B reprograms the proliferation, migrati...
Gut microbiota modulates visceral sensitivity through calcitonin gene-related peptide (CGRP) production [0.03%]
肠道微生物通过分泌降钙素基因相关肽调节内脏敏感性
Julien Pujo,Giada De Palma,Jun Lu et al.
Julien Pujo et al.
Abdominal pain is common in patients with gastrointestinal disorders, but its pathophysiology is unclear, in part due to poor understanding of basic mechanisms underlying visceral sensitivity. Accumulating evidence suggests that gut microbi...
A primary cell-based in vitro model of the human small intestine reveals host olfactomedin 4 induction in response to Salmonella Typhimurium infection [0.03%]
一种基于原代细胞的体外人类小肠模型揭示了宿主丝糊蛋白4在沙门氏菌感染后的表达响应机制
Thomas Däullary,Fabian Imdahl,Oliver Dietrich et al.
Thomas Däullary et al.
Infection research largely relies on classical cell culture or mouse models. Despite having delivered invaluable insights into host-pathogen interactions, both have limitations in translating mechanistic principles to human pathologies. Alt...
Meltem Dinleyici,Jana Barbieur,Ener Cagri Dinleyici et al.
Meltem Dinleyici et al.
Human milk oligosaccharides (HMOs) are the third most important solid component in human milk and act in tandem with other bioactive components. Individual HMO levels and distribution vary greatly between mothers by multiple variables, such...
Spatial variation of the gut microbiome in response to long-term metformin treatment in high-fat diet-induced type 2 diabetes mouse model of both sexes [0.03%]
高脂饮食诱导的二型糖尿病小鼠模型中，长期使用二甲双胍治疗对雄性和雌性肠道菌群空间变异性的响应差异研究
Laila Silamiķele,Rihards Saksis,Ivars Silamiķelis et al.
Laila Silamiķele et al.
Antidiabetic drug metformin alters the gut microbiome composition in the context of type 2 diabetes and other diseases; however, its effects have been mainly studied using fecal samples, which offer limited information about the intestinal ...
Zheng Zhou,Wenjing Yang,Tianming Yu et al.
Zheng Zhou et al.
G-protein coupled receptor 120 (GPR 120) has been implicated in anti-inflammatory functions. However, how GPR120 regulates the neutrophil function remains unknown. This study investigated the role of GPR120 in the regulation of neutrophil f...
A systematic review of associations between gut microbiota composition and growth failure in preterm neonates [0.03%]
一项关于早产新生儿肠道微生物群组成与生长发育不良之间关联的系统性综述
Larissa L Neves,Amy B Hair,Geoffrey A Preidis
Larissa L Neves
Growth failure is among the most prevalent and devastating consequences of prematurity. Up to half of all extremely preterm neonates struggle to grow despite modern nutrition practices. Although elegant preclinical models suggest causal rol...