Guanru Qian,Xiaolin Chen,Gang Liu et al.
Guanru Qian et al.
Colitis represents a significant global health concern, with its incidence rising annually in recent years. Despite the unclear specifics of its pathogenic mechanisms, dysbiosis of the intestinal microbiota is recognized as a major factor c...
Human microbiota influence the immune cell composition and gene expression in the tumor environment of a murine model of glioma [0.03%]
人体微生物群影响胶质瘤小鼠模型中肿瘤微环境的免疫细胞组成和基因表达
George B H Green,Alexis N Cox-Holmes,Gillian H Marlow et al.
George B H Green et al.
Background: Immunotherapy has shown success against other cancers but not glioblastoma. Previous data has revealed that microbiota influences anti-PD-1 efficacy. We have previously found that, when using gnotobiotic mice ...
Microbiome signatures of virulence in the oral-gut-brain axis influence Parkinson's disease and cognitive decline pathophysiology [0.03%]
口腔-肠道-大脑轴的毒力微生物组标志物影响帕金森病和认知衰退的病理生理学
Frederick Clasen,Suleyman Yildirim,Muzaffer Arıkan et al.
Frederick Clasen et al.
The human microbiome is increasingly recognized for its crucial role in the development and progression of neurodegenerative diseases. While the gut-brain axis has been extensively studied, the contribution of the oral microbiome and gut-or...
Wenqiang Shen,Jan Freark de Boer,Folkert Kuipers et al.
Wenqiang Shen et al.
Gut microorganisms inhabiting the intestinal tract play key roles in host's health and disease. A properly functioning gut microbiome requires the availability of adequate carbon, nitrogen and energy sources. One of the main sources of ener...
Fecal microbiota transplantation from a healthy pouch donor for chronic pouchitis: a proof-of-concept study [0.03%]
健康储袋捐献者粪菌移植治疗慢性储袋炎的概念验证研究
Sabrina Just Kousgaard,Sebastian Mølvang Dall,Mads Albertsen et al.
Sabrina Just Kousgaard et al.
Chronic pouchitis is a common complication after ileal pouch-anal anastomosis (IPAA) with limited treatment options. In this case series, we aimed to investigate clinical and microbiome changes, as well as adverse events, associated with us...
Bacteroides uniformis-generated hexadecanedioic acid ameliorates metabolic-associated fatty liver disease [0.03%]
黏附拟杆菌生成的己二酸通过调节色氨酸代谢改善代谢相关脂肪性肝病
Da-Ya Zhang,Da Li,Shi-Ju Chen et al.
Da-Ya Zhang et al.
Gut microbiota exerts a pivotal influence on the development of Metabolic Associated Fatty Liver Disease (MAFLD), although the specific contributions of individual bacterial strains and their metabolites remain poorly defined. We conducted ...
Indole-3-lactic acid suppresses colorectal cancer via metabolic reprogramming [0.03%]
吲哚-3-乳酸通过代谢重编程抑制结直肠癌
Shizhen Zhou,Kai Wang,Jiandong Huang et al.
Shizhen Zhou et al.
Research indicates that abnormal gut microbiota metabolism is linked to colorectal cancer (CRC) progression, but the role of microbiota-related tryptophan metabolism disruption remains unclear. Using metagenomic sequencing and targeted Trp ...
Adaptations in gut Bacteroidales facilitate stable co-existence with their lytic bacteriophages [0.03%]
肠道菌Bacteroidales的适应进化使其能够与裂解性噬菌体和平共存
Adrián Cortés-Martín,Colin Buttimer,Jessie L Maier et al.
Adrián Cortés-Martín et al.
Bacteriophages (phages) and bacteria within the gut microbiome persist in long-term stable coexistence. These interactions are driven by eco-evolutionary dynamics, where bacteria employ a variety of mechanisms to evade phage infection, whil...
Metaproteomics reveals age-specific alterations of gut microbiome in hamsters with SARS-CoV-2 infection [0.03%]
代谢蛋白质组学揭示了感染SARS-CoV-2的地鼠肠道微生物群的年龄特异性改变
Marybeth Creskey,Fabiola Silva Angulo,Qing Wu et al.
Marybeth Creskey et al.
The gut microbiome's pivotal role in health and disease is well established. SARS-CoV-2 infection often causes gastrointestinal symptoms and is associated with changes of the microbiome in both human and animal studies. While hamsters serve...
Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism [0.03%]
mango苷转化norathyriol的机制及其对短链脂肪酸和尿酸代谢的影响研究
Daan Bunt,Markus Schwalbe,Fittree Hayeeawaema et al.
Daan Bunt et al.
Mangiferin (MAN), a natural C-glycosylxanthone, is recognized for its health-promoting effects in traditional medicinal preparations. However, its poor bioavailability and limited intestinal permeability restrict its direct biological activ...