Bifidobacterium longum subsp. infantis utilizes human milk urea to recycle nitrogen within the infant gut microbiome [0.03%]
婴儿拟杆菌亚种利用人类母乳中的尿素在婴儿肠道菌群中回收氮元素
Xiaomeng You,Asha Rani,Ezgi Özcan et al.
Xiaomeng You et al.
Human milk guides the structure and function of microbial commensal communities that colonize the nursing infant gut. Indigestible molecules dissolved in human milk establish a microbiome often dominated by bifidobacteria capable of utilizi...
Glycoursodeoxycholic acid regulates bile acids level and alters gut microbiota and glycolipid metabolism to attenuate diabetes [0.03%]
甘尿酮脱氧胆酸调节胆汁酸水平并改变肠道菌群和糖脂代谢以缓解糖尿病
Bingting Chen,Yu Bai,Fenglian Tong et al.
Bingting Chen et al.
Accumulating evidence suggests that the bile acid regulates type 2 diabetes mellitus (T2DM) through gut microbiota-host interactions. However, the mechanisms underlying such interactions have been unclear. Here, we found that glycoursodeoxy...
YAP and β-catenin cooperate to drive H. pylori-induced gastric tumorigenesis [0.03%]
YAP和β-catenin合作驱动幽门螺旋杆菌诱导的胃肿瘤发生
Nianshuang Li,Xinbo Xu,Yuan Zhan et al.
Nianshuang Li et al.
H. pylori infection is the strongest known risk factor for gastric carcinoma. The activation of the yes-associated protein 1 (YAP) and β-catenin pathways has been associated with multiple tumor types. In this study, we investigated the cro...
Clostridioides difficile aggravates dextran sulfate solution (DSS)-induced colitis by shaping the gut microbiota and promoting neutrophil recruitment [0.03%]
艰难梭菌通过塑造肠道微生物群并促进中性粒细胞募集来加重硫酸葡聚糖诱导的结肠炎
Danfeng Dong,Tongxuan Su,Wei Chen et al.
Danfeng Dong et al.
Clostridioides difficile is a pathogen contributing to increased morbidity and mortality of patients with inflammatory bowel disease (IBD). To determine how C. difficile affects the severity of colitis, we constructed a dextran sulfate solu...
Enterohemorrhagic Escherichia coli responds to gut microbiota metabolites by altering metabolism and activating stress responses [0.03%]
肠出血性大肠杆菌通过改变代谢和激活压力反应来响应肠道微生物群代谢物
Stefanie L Vogt,Antonio Serapio-Palacios,Sarah E Woodward et al.
Stefanie L Vogt et al.
Enterohemorrhagic Escherichia coli (EHEC) is a major cause of severe bloody diarrhea, with potentially lethal complications, such as hemolytic uremic syndrome. In humans, EHEC colonizes the colon, which is also home to a diverse community o...
Epithelial talin-1 protects mice from citrobacter rodentium-induced colitis by restricting bacterial crypt intrusion and enhancing t cell immunity [0.03%]
上皮talin-1通过限制细菌隐窝入侵和增强T细胞免疫来保护小鼠免受大肠杆菌诱导的结肠炎的影响
Yvonne L Latour,Margaret M Allaman,Daniel P Barry et al.
Yvonne L Latour et al.
Pathogenic enteric Escherichia coli present a significant burden to global health. Food-borne enteropathogenic E. coli (EPEC) and Shiga toxin-producing E. coli (STEC) utilize attaching and effacing (A/E) lesions and actin-dense pedestal for...
E. coli Common pili promote the fitness and virulence of a hybrid aEPEC/ExPEC strain within diverse host environments [0.03%]
大肠杆菌共同菌毛通过促进致病性增强溶源性杂交aEPEC/ExPEC菌株的适应度来感染不同的宿主环境
Danielle D Munhoz,Amanda C Richards,Fernanda F Santos et al.
Danielle D Munhoz et al.
Pathogenic subsets of Escherichia coli include diarrheagenic (DEC) strains that cause disease within the gut and extraintestinal pathogenic E. coli (ExPEC) strains that are linked with urinary tract infections, bacteremia, and other infecti...
Succinate metabolism and its regulation of host-microbe interactions [0.03%]
琥珀酸代谢及其对宿主-微生物相互作用的调节作用
Yi-Han Wei,Xi Ma,Jiang-Chao Zhao et al.
Yi-Han Wei et al.
Succinate is a circulating metabolite, and the relationship between abnormal changes in the physiological concentration of succinate and inflammatory diseases caused by the overreaction of certain immune cells has become a research focus. R...
Crohn's disease-associated AIEC inhibiting intestinal epithelial cell-derived exosomal let-7b expression regulates macrophage polarization to exacerbate intestinal fibrosis [0.03%]
粘附型肠上皮细胞(AIEC)通过抑制肠上皮来源的外泌体let-7b促进巨噬细胞极化从而加重克罗恩病相关肠道纤维化
Yihan Xu,Wenwei Qian,Liangyu Huang et al.
Yihan Xu et al.
The interaction between adherent-invasive Escherichia coli (AIEC) and intestinal macrophages is implicated in the pathogenesis of Crohn's disease (CD). However, its role in intestinal fibrogenesis and the underlying molecular mechanisms are...
Experimental diets dictate the metabolic benefits of probiotics in obesity [0.03%]
实验饮食决定了肥胖患者中益生菌的代谢益处
Ida Søgaard Larsen,Béatrice S-Y Choi,Bandik Föh et al.
Ida Søgaard Larsen et al.
Growing evidence supports the use of probiotics to prevent or mitigate obesity-related dysmetabolism and non-alcoholic fatty liver disease (NAFLD). However, frequent reports of responders versus non-responders to probiotic treatment warrant...