Maternal microbe-specific modulation of the offspring microbiome and development during pregnancy and lactation [0.03%]
孕期及哺乳期母体微生物对后代微生物组及发育的特定调节作用
Min Tian,Qihui Li,Tenghui Zheng et al.
Min Tian et al.
The maternal microbiome is essential for the healthy growth and development of offspring and has long-term effects later in life. Recent advances indicate that the maternal microbiome begins to regulate fetal health and development during p...
Natalia Szóstak,Marek Figlerowicz,Anna Philips
Natalia Szóstak
In recent years, it has become clear that gut microbiota plays a major role in the human body, both in health and disease. Because of that, the gut microbiome and its impact on human well-being are getting wider and wider attention. Studies...
SaaS sRNA promotes Salmonella intestinal invasion via modulating MAPK inflammatory pathway [0.03%]
SaaS小分子RNA通过调节MAPK炎症通路促进沙门氏菌肠道侵袭性研究
Linlin Cai,Yunting Xie,Liangting Shao et al.
Linlin Cai et al.
Salmonella Enteritidis is a foodborne enteric pathogen that infects humans and animals, utilizing complex survival strategies. Bacterial small RNA (sRNA) plays an important role in these strategies. However, the virulence regulatory network...
Recombinant production of a diffusible signal factor inhibits Salmonella invasion and animal carriage [0.03%]
可扩散信号因子的重组生产可抑制沙门氏菌侵袭和动物携带量
Mudasir Ali Rather,Rimi Chowdhury,Paulina D Pavinski Bitar et al.
Mudasir Ali Rather et al.
The complex chemical environment of the intestine is defined largely by the metabolic products of the resident microbiota. Enteric pathogens, elegantly evolved to thrive in the gut, use these chemical products as signals to recognize specif...
Fecal virome transfer improves proliferation of commensal gut Akkermansia muciniphila and unexpectedly enhances the fertility rate in laboratory mice [0.03%]
粪便病毒组移植提高共生肠道阿克曼氏菌的增殖率并意外改善实验小鼠生育力比率
Torben Sølbeck Rasmussen,Caroline M Junker Mentzel,Malene Refslund Danielsen et al.
Torben Sølbeck Rasmussen et al.
Probiotics are intended to improve gastrointestinal health when consumed. However, the probiotics marketed today only colonize the densely populated gut to a limited extent. Bacteriophages comprise the majority of viruses in the human gut v...
Performance of Gut Microbiome as an Independent Diagnostic Tool for 20 Diseases: Cross-Cohort Validation of Machine-Learning Classifiers [0.03%]
肠道微生物组作为独立诊断工具诊断20种疾病的性能：机器学习分类器的跨队列验证
Min Li,Jinxin Liu,Jiaying Zhu et al.
Min Li et al.
Cross-cohort validation is essential for gut-microbiome-based disease stratification but was only performed for limited diseases. Here, we systematically evaluated the cross-cohort performance of gut microbiome-based machine-learning classi...
The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset [0.03%]
婴儿时期的丙酸盐-GPR41轴可预防日后支气管哮喘发作
Takashi Ito,Yumiko Nakanishi,Ryohei Shibata et al.
Takashi Ito et al.
Evidence has accumulated that gut microbiota and its metabolites, in particular the short-chain fatty acid propionate, are significant contributors to the pathogenesis of a variety of diseases. However, little is known regarding its impact ...
Crohn's disease proteolytic microbiota enhances inflammation through PAR2 pathway in gnotobiotic mice [0.03%]
克罗恩病蛋白酶型肠道菌群通过无菌小鼠的PAR2通路增强炎症反应
Alba Santiago,Amber Hann,Marco Constante et al.
Alba Santiago et al.
Emerging evidence implicates microbial proteolytic activity in ulcerative colitis (UC), but whether it also plays a role in Crohn's disease (CD) remains unclear. We investigated the effects of colonizing adult and neonatal germ-free C57BL/6...
Ghada Tafesh-Edwards,Ioannis Eleftherianos
Ghada Tafesh-Edwards
The gut epithelia of virtually all animals harbor complex microbial communities that play an important role in maintaining immune and cellular homeostasis. Gut microbiota have evolutionarily adapted to the host gut environment, serving as k...
Interlink between the gut microbiota and inflammation in the context of oxidative stress in Alzheimer's disease progression [0.03%]
氧化应激背景下肠道微生物群与阿尔茨海默病进程中的炎症之间的相互作用关系
Tushar K Das,Bhanu P Ganesh
Tushar K Das
The microbiota-gut-brain axis is an important pathway of communication and may dynamically contribute to Alzheimer's disease (AD) pathogenesis. Pathological commensal gut microbiota alterations, termed as dysbiosis, can influence intestinal...