Systemic exposure to bacterial amyloid curli alters the gut mucosal immune response and the microbiome, exacerbating Salmonella-induced arthritis [0.03%]
细菌淀粉样蛋白Curli的全身暴露改变肠道黏膜免疫反应和微生物群，加重沙门氏菌诱导的关节炎
Shingo Bessho,Kaitlyn C M Grando,Kathrine Kyrylchuk et al.
Shingo Bessho et al.
The Salmonella biofilm-associated amyloid protein, curli, is a dominant instigator of systemic inflammation and autoimmune responses following Salmonella infection. Systemic curli injections or infection of mice with Salmonella Typhimurium ...
Nadège Bossuet,Cécile Guyonnet,Camille V Chagneau et al.
Nadège Bossuet et al.
Up to 25% of the E. coli strains isolated from the feces of healthy humans harbor the pks genomic island encoding the synthesis of colibactin, a genotoxic metabolite. Evidence is accumulating for an etiologic role of colibactin in colorecta...
Johannes W Duess,Maame E Sampah,Carla M Lopez et al.
Johannes W Duess et al.
Necrotizing enterocolitis (NEC) is a devastating disease in premature infants and the leading cause of death and disability from gastrointestinal disease in this vulnerable population. Although the pathophysiology of NEC remains incompletel...
Dietary iron modulates gut microbiota and induces SLPI secretion to promote colorectal tumorigenesis [0.03%]
膳食铁调节肠道微生物群并诱导SLPI分泌以促进结直肠肿瘤发生
Chen Liu,Junli Gong,Qiang Zhang et al.
Chen Liu et al.
Dietary iron intake is closely related to the incidence of colorectal cancer. However, the interactions among dietary iron, gut microbiota, and epithelial cells in promoting tumorigenesis have rarely been discussed. Here, we report that gut...
Resynchronized rhythmic oscillations of gut microbiota drive time-restricted feeding induced nonalcoholic steatohepatitis alleviation [0.03%]
肠道微生物群的同步节奏振荡驱动时间限制性进食诱导的非酒精性脂肪肝病缓解
Jiafeng Xia,Wanru Guo,Ming Hu et al.
Jiafeng Xia et al.
With the drive of the endogenous circadian clock and external cues such as feeding behavior, the microbial community generates rhythmic oscillations in composition and function. Microbial oscillations are crucial in orchestrating host metab...
Dynamic associations between the respiratory tract and gut antibiotic resistome of patients with COVID-19 and its prediction power for disease severity [0.03%]
COVID-19患者呼吸道与肠道抗生素抗性基因动态关联及其预测疾病严重性的能力
Yifei Shen,Wenxin Qu,Fei Yu et al.
Yifei Shen et al.
The antibiotic resistome is the collection of all antibiotic resistance genes (ARGs) present in an individual. Whether an individual's susceptibility to infection and the eventual severity of coronavirus disease 2019 (COVID-19) is influence...
Deletion of hepatic growth hormone receptor (GHR) alters the mouse gut microbiota by affecting bile acid metabolism [0.03%]
肝GH受体的缺失通过影响胆汁酸代谢改变小鼠肠道微生物群
Zichao Yu,Yu Wang,Fang Zhang et al.
Zichao Yu et al.
Both growth hormone (GH) and gut microbiota play significant roles in diverse physiological processes, but the crosstalk between them is poorly understood. Despite the regulation of GH by gut microbiota, study on GH's influence on gut micro...
MMINP: A computational framework of microbe-metabolite interactions-based metabolic profiles predictor based on the O2-PLS algorithm [0.03%]
基于O2-PLS算法的微生物-代谢物相互作用-Based代谢谱预测器的计算框架/MMINP计算框架
Wenli Tang,Huimin Zheng,Shuangbin Xu et al.
Wenli Tang et al.
The gut metabolome acts as an intermediary between the gut microbiota and host, and has tremendous diagnostic and therapeutic potential. Several studies have utilized bioinformatic tools to predict metabolites based on the different aspects...
Genome-wide multi-omics analysis reveals the nutrient-dependent metabolic features of mucin-degrading gut bacteria [0.03%]
泛基因组多组学分析揭示了黏液降解肠道细菌的营养依赖型代谢特征
Kyoung Su Kim,Eunike Tiffany,Ji-Young Lee et al.
Kyoung Su Kim et al.
The prevalence and occurrence of mucin-degrading (MD) bacteria, such as Akkermansia muciniphila and Ruminococcus gnavus, is highly associated with human health and disease states. However, MD bacterial physiology and metabolism remain elusi...
Altered intestinal microbiome and epithelial damage aggravate intestinal graft-versus-host disease [0.03%]
肠道微生物组改变和上皮损伤会加重肠移植物抗宿主病
Fei Gao,Hengwei Wu,Limengmeng Wang et al.
Fei Gao et al.
Despite significant achievements in hematopoietic stem cell transplantation (HSCT), graft-versus-host disease (GVHD), especially intestinal GVHD, remains a major obstacle to this procedure. GVHD has long been regarded as a pathogenic immune...