Increased intestinal permeability and downregulation of absorptive ion transporters Nhe3, Dra, and Sglt1 contribute to diarrhea during Clostridioides difficile infection [0.03%]
艰难梭菌感染相关腹泻与肠道通透性增加及吸收入胞转运蛋白NHE3、DRA和SGLT1表达下调有关
F Christopher Peritore-Galve,Izumi Kaji,Anna Smith et al.
F Christopher Peritore-Galve et al.
Background & aim: Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced by C. difficile are the major determi...
Alterations in the gut virome are associated with type 2 diabetes and diabetic nephropathy [0.03%]
肠道病毒组的改变与2型糖尿病和糖尿病肾病相关
Gang Fan,Feng Cao,Tingting Kuang et al.
Gang Fan et al.
Although changes in gut microbiome have been associated with the development of T2D and its complications, the role of the gut virome remains largely unknown. Here, we characterized the gut virome alterations in T2D and its complications di...
The claim of primacy of human gut Bacteroides ovatus in dietary cellobiose degradation [0.03%]
拟杆菌门卵形拟杆菌在饮食次氯酸盐降解中的主导地位的宣称
Meixia Li,Yeqing Wang,Ciliang Guo et al.
Meixia Li et al.
A demonstration of cellulose degrading bacterium from human gut changed our view that human cannot degrade the cellulose. However, investigation of cellulose degradation by human gut microbiota on molecular level has not been completed so f...
Akkermansia muciniphila inhibits nonalcoholic steatohepatitis by orchestrating TLR2-activated γδT17 cell and macrophage polarization [0.03%]
Akkermansia muciniphila通过调控TLR2活化的γδT17细胞和巨噬细胞极化抑制非酒精性脂肪肝炎
Yuqiu Han,Qi Ling,Li Wu et al.
Yuqiu Han et al.
Current evidence indicates that the next-generation probiotic Akkermansia muciniphila (A. muciniphila) has therapeutic potential for nonalcoholic fatty liver disease (NAFLD), especially its inflammatory stage known as nonalcoholic steatohep...
Gut microbiota in nonalcoholic fatty liver disease: a PREDIMED-Plus trial sub analysis [0.03%]
非酒精性脂肪肝病的肠道微生物群：一项PREDIMED-Plus试验的亚组分析
Ana María Gómez-Pérez,Patricia Ruiz-Limón,Jordi Salas-Salvadó et al.
Ana María Gómez-Pérez et al.
To evaluate the changes in the gut microbiota associated with changes in the biochemical markers of nonalcoholic fatty liver disease (NAFLD) after a lifestyle intervention with the Mediterranean diet. Participants (n = 297) from two centers...
Clinical Trial
Gut microbes. 2023 Jan-Dec;15(1):2223339. DOI:10.1080/19490976.2023.2223339 2023
Ordering taxa in image convolution networks improves microbiome-based machine learning accuracy [0.03%]
基于微生物组的机器学习准确性的图像卷积网络中的分类群排序改善了准确性
Oshrit Shtossel,Haim Isakov,Sondra Turjeman et al.
Oshrit Shtossel et al.
The human gut microbiome is associated with a large number of disease etiologies. As such, it is a natural candidate for machine-learning-based biomarker development for multiple diseases and conditions. The microbiome is often analyzed usi...
Comparative genomics and phenotypic studies to determine site-specificity of Escherichia coli in the lower gastrointestinal tract of humans [0.03%]
比较基因组学和表型研究确定大肠埃希氏菌在人类下消化道中的定位特异性
Rasel Barua,Paul Pavli,David M Gordon et al.
Rasel Barua et al.
Escherichia coli (E. coli) is an important commensal in the human gut; however, it is unknown whether strains show site-specificity in the lower gut. To investigate this, we assessed genotypic and phenotypic differences in 37 clone pairs (t...
L-Arabinose inhibits Shiga toxin type 2-converting bacteriophage induction in Escherichia coli O157:H7 [0.03%]
L-阿拉伯糖可抑制志贺毒素2型转化噬菌体在大肠杆菌O157:H7中的诱导作用
Jie Hu,Yifan Wu,Xingjian Zhou et al.
Jie Hu et al.
The pathogenicity of Escherichia coli (E. coli) O157:H7 is predominantly associated with Shiga toxin 2 (Stx2) that poses a huge threat to human and animal intestinal health. Production of Stx2 requires expression of stx2 gene, which is loca...
Gut microbiota changes associated with Clostridioides difficile infection and its various treatment strategies [0.03%]
与艰难梭菌感染及其不同治疗策略相关的肠道微生物群变化
Anne J Gonzales-Luna,Travis J Carlson,Kevin W Garey
Anne J Gonzales-Luna
Human gut microbiota are critical to both the development of and recovery from Clostridioides difficile infection (CDI). Antibiotics are the mainstay of CDI treatment, yet inherently cause further imbalances in the gut microbiota, termed dy...
Faecal Microbiota transplantation affects liver DNA methylation in Non-alcoholic fatty liver disease: a multi-omics approach [0.03%]
粪便微生物移植通过多组学方法影响非酒精性脂肪肝患者的肝脏DNA甲基化状态
Daniela Stols-Gonçalves,Anne Linde Mak,Mette S Madsen et al.
Daniela Stols-Gonçalves et al.
Individuals with nonalcoholic fatty liver disease (NAFLD) have an altered gut microbiota composition. Moreover, hepatic DNA methylation may be altered in the state of NAFLD. Using a fecal microbiota transplantation (FMT) intervention, we ai...