Exosomal-miR-129-2-3p derived from Fusobacterium nucleatum-infected intestinal epithelial cells promotes experimental colitis through regulating TIMELESS-mediated cellular senescence pathway [0.03%]
牙龈卟啉单胞菌感染的小肠上皮细胞来源的外泌体-miR-129-2-3p通过调节TIMELESS介导的衰老通路促进实验性结肠炎
Shuchun Wei,Xiaohan Wu,Meilin Chen et al.
Shuchun Wei et al.
Fusobacterium nucleatum (Fn) infection is known to exacerbate ulcerative colitis (UC). However, the link between Fn-infected intestinal epithelial cell (IEC)-derived exosomes (Fn-Exo) and UC progression has not been investigated. Differenti...
Citizen science helps to raise awareness about gut microbiome health in people at risk of developing non-communicable diseases [0.03%]
市民科学有助于提高人们对肠道微生物组健康的意识，以预防非传染性疾病的发生风险
Silvia Garcia,Sheyla Ordoñez,Victor Manuel López-Molina et al.
Silvia Garcia et al.
Citizens lack knowledge about the impact of gut microbiota on health and how lifestyle and dietary choices can influence it, leading to Non-Communicable Diseases (NCDs) and affecting overall well-being. Participatory action research (PAR) i...
Genetic and gut microbiome determinants of SCFA circulating and fecal levels, postprandial responses and links to chronic and acute inflammation [0.03%]
决定乙酸盐等短链脂肪酸循环及粪便中水平、餐后反应的遗传和肠道菌群及其与慢性炎症和急性炎症的关系
Ana Nogal,Francesco Asnicar,Amrita Vijay et al.
Ana Nogal et al.
Short-chain fatty acids (SCFA) are involved in immune system and inflammatory responses. We comprehensively assessed the host genetic and gut microbial contribution to a panel of eight serum and stool SCFAs in two cohorts (TwinsUK, n = 2507...
Intracellular glycogen accumulation by human gut commensals as a niche adaptation trait [0.03%]
人体肠道共生菌的细胞内糖原积累是一种生态位适应性状
Maria Esteban-Torres,Lorena Ruiz,Valerio Rossini et al.
Maria Esteban-Torres et al.
The human gut microbiota is a key contributor to host metabolism and physiology, thereby impacting in various ways on host health. This complex microbial community has developed many metabolic strategies to colonize, persist and survive in ...
The phospholipase effector Tle1Vc promotes Vibrio cholerae virulence by killing competitors and impacting gene expression [0.03%]
磷脂酶效应物Tle1Vc通过杀死竞争对手并影响基因表达来促进霍乱弧菌的致病性
Ming Liu,Heng Wang,Ying Liu et al.
Ming Liu et al.
Vibrio cholerae utilizes the Type VI secretion system (T6SS) to gain an advantage in interbacterial competition by delivering anti-prokaryotic effectors in a contact-dependent manner. However, the impact of T6SS and its secreted effectors o...
Protection against Metabolic Associated Fatty Liver Disease by Protocatechuic Acid [0.03%]
没食子酸通过调节肠道菌群防治非酒精性脂肪肝病作用及机制研究
Jijun Tan,Ruizhi Hu,Jiatai Gong et al.
Jijun Tan et al.
Gut microbiota-diet interaction has been identified as a key factor of metabolic associated fatty liver disease (MAFLD). Recent studies suggested that dietary polyphenols may protect against MAFLD by regulating gut microbiota; however, the ...
Unveiling and harnessing the human gut microbiome in the rising burden of non-communicable diseases during urbanization [0.03%]
城市化进程中非传染性疾病负担加剧下的肠道微生物群的揭示与利用
Ziyu Huang,Yue Li,Heekuk Park et al.
Ziyu Huang et al.
The world is witnessing a global increase in the urban population, particularly in developing Asian and African countries. Concomitantly, the global burden of non-communicable diseases (NCDs) is rising, markedly associated with the changing...
Zikai Wang,Wanyue Dan,Nana Zhang et al.
Zikai Wang et al.
Colorectal cancer (CRC) is the third most common malignant tumor worldwide. The incidence and mortality rates of CRC have been increasing in China, possibly due to economic development, lifestyle, and dietary changes. Evidence suggests that...
Transplantation of gut microbiota from old mice into young healthy mice reduces lean mass but not bone mass [0.03%]
将老年小鼠的肠道微生物移植到年轻健康小鼠体内可减少肌肉量而非骨量
Lina Lawenius,Carrie Cowardin,Louise Grahnemo et al.
Lina Lawenius et al.
Aging is associated with low bone and lean mass as well as alterations in the gut microbiota (GM). In this study, we determined whether the reduced bone mass and relative lean mass observed in old mice could be transferred to healthy young ...
Fecal virome transplantation is sufficient to alter fecal microbiota and drive lean and obese body phenotypes in mice [0.03%]
粪便病毒组移植足以改变小鼠粪便菌群并驱动瘦型和肥胖体型现象
Joshua M Borin,Roland Liu,Yanhan Wang et al.
Joshua M Borin et al.
The gastrointestinal microbiome plays a significant role in modulating numerous host processes, including metabolism. Prior studies show that when mice receive fecal transplants from obese donors on high-fat diets (HFD) (even when recipient...