Linking serum vitamin D levels with gut microbiota after 1-year lifestyle intervention with Mediterranean diet in patients with obesity and metabolic syndrome: a nested cross-sectional and prospective study [0.03%]
地中海饮食肥胖和代谢综合征患者为期一年的生活方式干预后血清维生素D水平与肠道微生态的关系：一项嵌套的横断面及前瞻性研究
Hatim Boughanem,Patricia Ruiz-Limón,Jesús Pilo et al.
Hatim Boughanem et al.
Vitamin D, microbiota, and the Mediterranean diet (MedDiet) have been the focus of recent research due to their potential role in maintaining overall health. We hypothesize that MedDiet may alter the gut microbiota profile through changes i...
Gut microbiome diversity, variability, and latent community types compared with shifts in body weight during the freshman year of college in dormitory-housed adolescents [0.03%]
与大学新生宿舍居民体重变化相比的肠道微生物多样性、可变性和潜在群落类型
Alex E Mohr,Mary M Ahern,Dorothy D Sears et al.
Alex E Mohr et al.
Significant human gut microbiome changes during adolescence suggest that microbial community evolution occurs throughout important developmental periods including the transition to college, a typical life phase of weight gain. In this obser...
Observational Study
Gut microbes. 2023 Dec;15(2):2250482. DOI:10.1080/19490976.2023.2250482 2023
Microbial metabolite butyrate promotes anti-PD-1 antitumor efficacy by modulating T cell receptor signaling of cytotoxic CD8 T cell [0.03%]
微生物代谢产物丁酸通过调节细胞毒CD8 T细胞的T细胞受体信号促进抗PD-1抗肿瘤疗效
Xinhai Zhu,Ke Li,Guichao Liu et al.
Xinhai Zhu et al.
Recent studies have demonstrated that the antitumor immunity of immune cells can be modulated by gut microbiota and their metabolites. However, the underlying mechanisms remain unclear. Here, we showed that the serum butyric acid level is p...
Multimodal metagenomic analysis reveals microbial single nucleotide variants as superior biomarkers for early detection of colorectal cancer [0.03%]
多模态元基因组分析揭示了微生物单核苷酸变异可作为早期检测结直肠癌的优质生物标志物
Wenxing Gao,Xiang Gao,Lixin Zhu et al.
Wenxing Gao et al.
Microbial signatures show remarkable potentials in predicting colorectal cancer (CRC). This study aimed to evaluate the diagnostic powers of multimodal microbial signatures, multi-kingdom species, genes, and single-nucleotide variants (SNVs...
Statistical normalization methods in microbiome data with application to microbiome cancer research [0.03%]
宏基因组学数据的统计归一化方法及其在肿瘤研究中的应用
Yinglin Xia
Yinglin Xia
Mounting evidence has shown that gut microbiome is associated with various cancers, including gastrointestinal (GI) tract and non-GI tract cancers. But microbiome data have unique characteristics and pose major challenges when using standar...
Targeting the gut microbiota with dietary fibers: a novel approach to prevent the development cardiovascular complications linked to systemic lupus erythematosus in a preclinical study [0.03%]
以膳食纤维为目标调节肠道菌群：一项预防系统性红斑狼疮相关心血管并发症的临床前研究的新方法
Javier Moleón,Cristina González-Correa,Iñaki Robles-Vera et al.
Javier Moleón et al.
This study is to investigate whether dietary fiber intake prevents vascular and renal damage in a genetic mouse model of systemic lupus erythematosus (SLE), and the contribution of gut microbiota in the protective effects. Female NZBWF1 (SL...
Unveiling the complex relationship between gut microbiota and liver cancer: opportunities for novel therapeutic interventions [0.03%]
揭示肠道微生物群与肝癌的复杂关系：新型治疗干预的机会
Jayashi Rajapakse,Saroj Khatiwada,Anna Camille Akon et al.
Jayashi Rajapakse et al.
Hepatocellular carcinoma (HCC) has been linked to the gut microbiota, with recent studies revealing the potential of gut-generated responses to influence several arms of the immune responses relevant to HCC formation. The pro- or anti-tumor...
Effect of synbiotic supplementation on immune parameters and gut microbiota in healthy adults: a double-blind randomized controlled trial [0.03%]
益生元联合益生菌补充对健康成人免疫指标及肠道微生物的影响：双盲随机对照试验
Xiaoqin Li,Shan Hu,Jiawei Yin et al.
Xiaoqin Li et al.
Synbiotics are increasingly used by the general population to boost immunity. However, there is limited evidence concerning the immunomodulatory effects of synbiotics in healthy individuals. Therefore, we conducted a double-blind, randomize...
Randomized Controlled Trial
Gut microbes. 2023 Dec;15(2):2247025. DOI:10.1080/19490976.2023.2247025 2023
The microbiome landscape in pediatric Crohn's disease and therapeutic implications [0.03%]
儿童克罗恩病中的微生物组及其治疗意义
Karin Fetter,Markus Weigel,Benjamin Ott et al.
Karin Fetter et al.
Dysbiosis of the gut microbiome and a pathological immune response in intestinal tissues form the basis of Crohn's disease (CD), which is a debilitating disease with relevant morbidity and mortality. It is increasing in childhood and adoles...
The waxy mutation in sorghum and other cereal grains reshapes the gut microbiome by reducing levels of multiple beneficial species [0.03%]
蜡质突变通过降低多种有益微生物的水平来重塑谷物和其它谷物的肠道微生物群
Qinnan Yang,Mallory Van Haute,Nate Korth et al.
Qinnan Yang et al.
Waxy starches from cereal grains contain >90% amylopectin due to naturally occurring mutations that block amylose biosynthesis. Waxy starches have unique organoleptic characteristics (e.g. sticky rice) as well as desirable physicochemical p...