Exploring the inhibitory potential of the antiarrhythmic drug amiodarone against Clostridioides difficile toxins TcdA and TcdB [0.03%]
研究抗心律失常药物胺碘酮对抗艰难梭菌毒素TcdA和TcdB的抑制潜力
Judith Schumacher,Astrid Nienhaus,Sebastian Heber et al.
Judith Schumacher et al.
The intestinal pathogen Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in humans. The symptoms of C. difficile-associated diseases (CDADs) are directly associated with the pathog...
Human gut microbiome and metabolite dynamics under simulated microgravity [0.03%]
模拟微重力下的人体肠道微生物组和代谢物动力学
Ana Ramos-Nascimento,Lucia Grenga,Sven-Bastiaan Haange et al.
Ana Ramos-Nascimento et al.
The Artificial Gravity Bed Rest - European Space Agency (AGBRESA) study was the first joint bed rest study by ESA, DLR, and NASA that examined the effect of simulated weightlessness on the human body and assessed the potential benefits of a...
Gut virome profiling identifies an association between temperate phages and colorectal cancer promoted by Helicobacter pylori infection [0.03%]
肠道病毒组谱分析发现温和噬菌体与幽门螺杆菌感染促进的结直肠癌之间存在关联
Shiqi Luo,Jinlong Ru,Mohammadali Khan Mirzaei et al.
Shiqi Luo et al.
Colorectal cancer (CRC) is one of the most commonly diagnosed cancers worldwide. While a close correlation between chronic Helicobacter pylori infection and CRC has been reported, the role of the virome has been overlooked. Here, we infecte...
Impact of milk secretor status on the fecal metabolome and microbiota of breastfed infants [0.03%]
乳糖分泌状况对母乳喂养婴儿粪便代谢物和微生物群的影响
Aidong Wang,Aly Diana,Sofa Rahmannia et al.
Aidong Wang et al.
Maternal secretor status has been shown to be associated with the presence of specific fucosylated human milk oligosaccharides (HMOs), and the impact of maternal secretor status on infant gut microbiota measured through 16s sequencing has p...
Alterations of milk oligosaccharides in mothers with gestational diabetes mellitus impede colonization of beneficial bacteria and development of RORγt+ Treg cell-mediated immune tolerance in neonates [0.03%]
妊娠糖尿病母亲乳糖改变妨碍新生儿有益菌定植及RORγt+Treg细胞介导免疫耐受发展
Xinke Li,Xixi Ning,Binqi Rui et al.
Xinke Li et al.
Gestational diabetes mellitus (GDM) is an increasing public health concern that significantly increases the risk of early childhood allergic diseases. Altered maternal milk glycobiome may strongly affect gut microbiota and enteric-specific ...
Rimi Chowdhury,Paulina D Pavinski Bitar,Katherine E Bell et al.
Rimi Chowdhury et al.
The enteric pathogens have evolved to utilize elements from their surroundings to optimize their infection strategies. A common mechanism to achieve this is to employ intestinal compounds as signals to control the activity of a master regul...
The edible plant microbiome: evidence for the occurrence of fruit and vegetable bacteria in the human gut [0.03%]
可食用植物微生物组：果蔬细菌存在于人体肠道的证据
Wisnu Adi Wicaksono,Tomislav Cernava,Birgit Wassermann et al.
Wisnu Adi Wicaksono et al.
Diversity of the gut microbiota is crucial for human health. However, whether fruit and vegetable associated bacteria contribute to overall gut bacterial diversity is still unknown. We reconstructed metagenome-assembled genomes from 156 fru...
Meryl Perlman,Stefania Senger,Smriti Verma et al.
Meryl Perlman et al.
The gastrointestinal (GI) epithelium plays a major role in nutrient absorption, barrier formation, and innate immunity. The development of organoid-based methodology has significantly impacted the study of the GI epithelium, particularly in...
Disruption of the microbiota-gut-brain axis is a defining characteristic of the α-Gal A (-/0) mouse model of Fabry disease [0.03%]
肠道菌群-肠道-大脑轴的破坏是α-半乳糖苷酶A(-/0)鼠模型中的Fabry病的一个特征性特点
C Delprete,R Rimondini Giorgini,E Lucarini et al.
C Delprete et al.
Fabry disease (FD) is an X-linked metabolic disease caused by a deficiency in α-galactosidase A (α-Gal A) activity. This causes accumulation of glycosphingolipids, especially globotriaosylceramide (Gb3), in different cells and organs. Neu...
Distinctive patterns of sulfide- and butyrate-metabolizing bacteria after bariatric surgery: potential implications for colorectal cancer risk [0.03%]
胃旁路手术后硫化物和丁酸盐代谢细菌的独特模式：对结直肠癌风险的潜在影响
Hisham Hussan,Steven K Clinton,Elizabeth M Grainger et al.
Hisham Hussan et al.
Despite improved cardiometabolic outcomes following bariatric surgery, its long-term impact on colorectal cancer (CRC) risk remains uncertain. In parallel, the influence of bariatric surgery on the host microbiome and relationships with dis...