Reversible aberrancies in gut microbiome of moderate and late preterm infants: results from a randomized, controlled trial [0.03%]
早产儿肠道微生物组可逆异常：一项随机对照试验的结果
Raakel Luoto,Anna Pärtty,Josef K Vogt et al.
Raakel Luoto et al.
The aim of this study was to obtain insight into the composition and function of the deviant gut microbiome throughout infancy in children born moderately and late preterm and their response to microbiome modulation. We characterized the lo...
Randomized Controlled Trial
Gut microbes. 2023 Dec;15(2):2283913. DOI:10.1080/19490976.2023.2283913 2023
Why are so many enteric pathogen infections asymptomatic? Pathogen and gut microbiome characteristics associated with diarrhea symptoms and carriage of diarrheagenic E. coli in northern Ecuador [0.03%]
为什么那么多肠道病原菌感染无症状？肠道病原体和微生物组特征与厄瓜多尔北部志贺毒素的大肠杆菌携带及腹泻症状的关系研究
Kelsey J Jesser,Gabriel Trueba,Konstantinos T Konstantinidis et al.
Kelsey J Jesser et al.
A high proportion of enteric infections, including those caused by diarrheagenic Escherichia coli (DEC), are asymptomatic for diarrhea. The factors responsible for the development of diarrhea symptoms, or lack thereof, remain unclear. Here,...
Multi-omics data reveals aberrant gut microbiota-host glycerophospholipid metabolism in association with neuroinflammation in APP/PS1 mice [0.03%]
多组学数据揭示了APP/PS1小鼠异常的肠道微生物群-宿主甘油磷脂代谢与神经炎症之间的关联
Xiaohang Qian,Wangxi Hai,Siyue Chen et al.
Xiaohang Qian et al.
Numerous studies have described the notable impact of gut microbiota on the brain in Alzheimer's disease (AD) via the gut - brain axis. However, the molecular mechanisms underlying the involvement of gut microbiota in the development of AD ...
Detecting host responses to microbial stimulation using primary epithelial organoids [0.03%]
利用主要上皮器官体检测微生物刺激下的宿主反应
Jette Bornholdt,Christina V Müller,Maria Juul Nielsen et al.
Jette Bornholdt et al.
The intestinal epithelium is constantly exposed to microbes residing in the lumen. Traditionally, the response to microbial interactions has been studied in cell lines derived from cancerous tissues, e.g. Caco-2. It is, however, unclear how...
Diet-induced shifts in the gut microbiota influence anastomotic healing in a murine model of colonic surgery [0.03%]
饮食诱导的肠道菌群变化会影响结直肠手术吻合口愈合：小鼠模型研究
Sonja Boatman,Thomas Kaiser,Harika Nalluri-Butz et al.
Sonja Boatman et al.
Host diet and gut microbiota interact to contribute to perioperative complications, including anastomotic leak (AL). Using a murine surgical model of colonic anastomosis, we investigated how diet and fecal microbial transplantation (FMT) im...
Gut microbiome and frailty: insight from genetic correlation and mendelian randomization [0.03%]
肠道微生物组和衰弱：来自遗传相关性和孟德尔随机化的启示
Guanghui Cui,Shaojie Li,Hui Ye et al.
Guanghui Cui et al.
Observational studies have shown that the gut microbiome is associated with frailty. However, whether these associations underlie causal effects remains unknown. Thus, this study aimed to assess the genetic correlation and causal relationsh...
Meta-Analysis
Gut microbes. 2023 Dec;15(2):2282795. DOI:10.1080/19490976.2023.2282795 2023
Gut-microbiota prompt activation of natural killer cell on alcoholic liver disease [0.03%]
酒精性肝病中肠道微生物促进自然杀伤细胞活化的作用机制研究
Jung A Eom,Jin-Ju Jeong,Sang Hak Han et al.
Jung A Eom et al.
The liver is rich in innate immune cells, such as natural killer (NK) cells, natural killer T cells, and Kupffer cells associated with the gut microbiome. These immune cells are dysfunctional owing to alcohol consumption. However, there is ...
Inhibition of intestinal FXR activity as a possible mechanism for the beneficial effects of a probiotic mix supplementation on lipid metabolism alterations and weight gain in mice fed a high fat diet [0.03%]
肠道FXR活性抑制可能是益生菌补充通过改善高脂饮食小鼠脂质代谢紊乱及肥胖的可能机制
Alice Beau,Bérengère Benoit,Mélanie Le Barz et al.
Alice Beau et al.
Supplementation with probiotics has emerged as a promising therapeutic tool to manage metabolic diseases. We investigated the effects of a mix of Bifidobacterium animalis subsp. lactis LA804 and Lactobacillus gasseri LA806 on high-fat (HF) ...
Pharmacomicrobiomics of cell-cycle specific anti-cancer drugs - is it a new perspective for personalized treatment of cancer patients? [0.03%]
细胞周期特异性抗癌药物的药用微生物组学——它能为癌症患者的个性化治疗提供新的视角吗？
Karolina Kaźmierczak-Siedlecka,Nikola Bulman,Paweł Ulasiński et al.
Karolina Kaźmierczak-Siedlecka et al.
Intestinal bacteria are equipped with an enzyme apparatus that is involved in the active biotransformation of xenobiotics, including drugs. Pharmacomicrobiomics, a new area of pharmacology, analyses interactions between bacteria and xenobio...
ArcB orchestrates the quorum-sensing system to regulate type III secretion system 1 in Vibrio parahaemolyticus [0.03%]
弧杆菌种溶血性弧菌中的ArcB通过群体感应系统调控第三类分泌系统1
Ce Zhang,Min Liu,Ying Wu et al.
Ce Zhang et al.
In many Vibrio species, virulence is regulated by quorum sensing, which is regulated by a complex, multichannel, two-component phosphorelay circuit. Through this circuit, sensor kinases transmit sensory information to the phosphotransferase...