Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model [0.03%]
基于生物反应器模型的质子泵抑制剂通过改变PH值而不是影响肠道菌群来增加艰难梭菌感染的风险
Julia Schumacher,Patrick Müller,Johannes Sulzer et al.
Julia Schumacher et al.
Clostridioides difficile infections often occur after antibiotic use, but they have also been linked to proton-pump inhibitor (PPI) therapy. The underlying mechanism - whether infection risk is due to a direct effect of PPIs on the gut micr...
Comprehensive analysis of Enterococcus spp. from two European healthy infant cohorts shows stable genomic traits including antimicrobial resistance (AMR) [0.03%]
来自两个欧洲健康婴儿队列的肠球菌综合分析显示包括抗微生物药物耐药性（AMR）在内的稳定基因特征
Muhammad Hassan Saeed,Magdalena Kujawska,Kristiana Ellen et al.
Muhammad Hassan Saeed et al.
Enterococcus spp. some of which are pathogenic, are common gut microbiota members, including also infants. Infants may be more susceptible to Enterococcus due to their developing gut ecosystems. It is unclear whether antibiotic resistance g...
Anxiety-like behavior during protracted morphine withdrawal is driven by gut microbial dysbiosis and attenuated with probiotic treatment [0.03%]
长期阿片类药物戒断引起的焦虑样行为由肠道微生物群失调驱动并可通过益生菌治疗缓解
Mark Oppenheimer,Junyi Tao,Shamsudheen Moidunny et al.
Mark Oppenheimer et al.
The development of anxiety during protracted opioid withdrawal heightens the risk of relapse into the cycle of addiction. Understanding the mechanisms driving anxiety during opioid withdrawal could facilitate the development of therapeutics...
Correction [0.03%]
改正通知书
Published Erratum
Gut microbes. 2025 Dec;17(1):2518803. DOI:10.1080/19490976.2025.2518803 2025
Gut microbiota in regulatory T cell generation and function: mechanisms and health implications [0.03%]
肠道菌群在调节性T细胞的产生和功能中的作用：机制及对健康的影响
Amit Sharma,Garima Sharma,Sin-Hyeog Im
Amit Sharma
The establishment and maintenance of immune homeostasis rely on a dynamic, bidirectional exchange of information between commensal microorganisms and the host immune system. At the center of this process are CD4+Foxp3+ regulatory T cells (T...
Probiotic-induced enrichment of Adlercreutzia equolifaciens increases gut microbiome wellness index and maps to lower host blood glucose levels [0.03%]
益生菌诱导的Adlercreutzia equolifaciens富集增加了肠道微生物组健康指数并映射到较低的宿主血糖水平上
Zeng Zhang,Zhihan Yang,Shijia Lin et al.
Zeng Zhang et al.
The gut microbiome is essential for maintaining host health, influencing gut function and metabolic regulation. While probiotics are widely used to manage gut health, evidence of their specific effects in healthy individuals remains limited...
Randomized Controlled Trial
Gut microbes. 2025 Dec;17(1):2520407. DOI:10.1080/19490976.2025.2520407 2025
Lachnospiraceae bacterium alleviates alcohol-associated liver disease by enhancing N-acetyl-glutamic acid levels and inhibiting ferroptosis through the KEAP1-NRF2 pathway [0.03%]
乳酸菌通过KEAP1-NRF2途径增强N-乙酰谷氨酸水平和抑制铁死亡来缓解酒精相关性肝病
Hejiao Zhang,Qiang Hu,Yong Zhang et al.
Hejiao Zhang et al.
Alcohol-associated liver disease (ALD) is a prevalent global health issue primarily caused by excessive alcohol consumption. Recent studies have highlighted the gut-liver axis's protective role against ALD, mainly through gut microbiota. Ho...
Fecal gut microbiota and amino acids as noninvasive diagnostic biomarkers of Pediatric inflammatory bowel disease [0.03%]
粪便肠道微生物群和氨基酸作为儿科炎症性肠病的非侵入式诊断生物标志物
Eva Vermeer,Jasmijn Z Jagt,Eline M Lap et al.
Eva Vermeer et al.
Background and aims: Fecal calprotectin (FCP) has limited specificity as diagnostic biomarker of pediatric inflammatory bowel disease (IBD), leading to unnecessary invasive endoscopies. This study aimed to develop and val...
The ladder of regulatory stringency and balance: an application to the US FDA's regulation of bacterial live therapeutics [0.03%]
基于美国FDA细菌活体治疗监管的严格性和平衡性梯度模型研究
Moshe Maor,Hilit Levy Barazany,Ilana Kolodkin-Gal
Moshe Maor
The three main types of live bacterial therapies - probiotics, fecal/microbiome transplants, and engineered bacterial therapies - hold immense potential to revolutionize medicine. While offering targeted and personalized treatments for vari...
Human gut commensal Alistipes timonensis modulates the host lipidome and delivers anti-inflammatory outer membrane vesicles to suppress colitis in an Il10-deficient mouse model [0.03%]
黏附产碱杆菌调控宿主脂质组分并分泌抗炎外膜囊泡抑制先天缺乏IL-10小鼠结肠炎恶化
Ethan A Older,Mary K Mitchell,Andrew Campbell et al.
Ethan A Older et al.
Correlative studies have linked human gut microbes to specific health conditions. Alistipes is one such microbial genus negatively linked to inflammatory bowel disease (IBD). However, the protective role of Alistipes in IBD is understudied,...