Gut microbiota-derived 12-ketolithocholic acid suppresses the IL-17A secretion from colonic group 3 innate lymphoid cells to prevent the acute exacerbation of ulcerative colitis [0.03%]
肠道菌群衍生的12-酮石胆酸通过抑制结肠固有层ILC3产生IL-17A来预防溃疡性结肠炎急性发作
Na Li,Peiguang Ma,Yalan Li et al.
Na Li et al.
Intestinal microbiota dysbiosis and metabolic disruption are well-known as the primary triggers of ulcerative colitis (UC). However, their role in regulating the group 3 innate lymphoid cells (ILC3s), which are essential for intestinal heal...
Marisel Rosell-Díaz,Elena Santos-González,Anna Motger-Albertí et al.
Marisel Rosell-Díaz et al.
Iron is required for the replication and growth of almost all bacterial species and in the production of myelin and neurotransmitters. Increasing clinical studies evidence that the gut microbiota plays a critical role in iron metabolism and...
Disentangling the age-related manner in the associations between gut microbiome and women's health: a multi-cohort microbiome study [0.03%]
基于多队列的肠道菌群与女性健康关联研究：解构年龄相关的关联模式
Chao Dong,Quanquan Guan,Wei Xu et al.
Chao Dong et al.
Women's health encompasses life-course healthcare, and mounting evidence emphasizes the pivotal contribution of gut microbiota. Therefore, understanding the temporal dynamics of gut microbiota and how age influences disease-gut microbiota a...
Evolution of E. coli in a mouse model of inflammatory bowel disease leads to a disease-specific bacterial genotype and trade-offs with clinical relevance [0.03%]
大肠杆菌在炎症性肠病小鼠模型中的进化导致了具有临床意义的特定疾病相关细菌基因型和权衡取舍
Rahul Unni,Nadia Andrea Andreani,Marie Vallier et al.
Rahul Unni et al.
Inflammatory bowel disease (IBD) is a persistent inflammatory condition that affects the gastrointestinal tract and presents significant challenges in its management and treatment. Despite the knowledge that within-host bacterial evolution ...
Efficacy of fecal microbiota transplantation in patients with Parkinson's disease: clinical trial results from a randomized, placebo-controlled design [0.03%]
随机对照安慰剂试验显示粪菌移植可改善帕金森病患者的运动功能与非运动功能症状
Yi Cheng,Guohua Tan,Qihui Zhu et al.
Yi Cheng et al.
The occurrence and development of Parkinson's disease (PD) have been demonstrated to be related to gut dysbiosis, however, the impact of fecal microbiota transplantation (FMT) on microbiota engraftment in PD patients is uncertain. We perfor...
Randomized Controlled Trial
Gut microbes. 2023 Dec;15(2):2284247. DOI:10.1080/19490976.2023.2284247 2023
Samuel J Gavzy,Allison Kensiski,Zachariah L Lee et al.
Samuel J Gavzy et al.
Bifidobacterium is a widely distributed commensal bacterial genus that displays beneficial pro-homeostatic and anti-inflammatory immunomodulatory properties. Depletion or absence of Bifidobacterium in humans and model organisms is associate...
Gut microbiome-associated predictors as biomarkers of response to advanced therapies in inflammatory bowel disease: a systematic review [0.03%]
肠道微生物组相关预测因子可作为炎症性肠病接受强化治疗后反应的生物标志物：系统综述
Susanna Meade,Jeremy Liu Chen Kiow,Cristian Massaro et al.
Susanna Meade et al.
Loss of response to therapy in inflammatory bowel disease (IBD) has led to a surge in research focusing on precision medicine. Three systematic reviews have been published investigating the associations between gut microbiota and disease ac...
Characterization of markers, functional properties, and microbiome composition in human gut-derived bacterial extracellular vesicles [0.03%]
人肠道来源细菌体外囊泡的表征、功能属性及微生物组组成分析
Chih-Chi Li,Wei-Fan Hsu,Po-Chieh Chiang et al.
Chih-Chi Li et al.
Past studies have confirmed the etiologies of bacterial extracellular vesicles (BEVs) in various diseases, including inflammatory bowel disease (IBD) and colorectal cancer (CRC). This study aimed to investigate the characteristics of stool-...
Gut microbiota induces weight gain and inflammation in the gut and adipose tissue independent of manipulations in diet, genetics, and immune development [0.03%]
肠道菌群在不影响饮食、遗传和免疫发育的情况下独立诱导体重增加和肠道及脂肪组织的炎症
Devesha H Kulkarni,Brigida Rusconi,Alexandria N Floyd et al.
Devesha H Kulkarni et al.
Obesity and the metabolic syndrome are complex disorders resulting from multiple factors including genetics, diet, activity, inflammation, and gut microbes. Animal studies have identified roles for each of these, however the contribution(s)...
Fecal microbiota transplanted from old mice promotes more colonic inflammation, proliferation, and tumor formation in azoxymethane-treated A/J mice than microbiota originating from young mice [0.03%]
老龄小鼠粪便微生物移植促进AZO甲烷处理的A/J小鼠结肠炎症、增殖和肿瘤形成多于年轻小鼠来源的微生物
Nicholas A Crossland,Samuel Beck,Wei Yu Tan et al.
Nicholas A Crossland et al.
Aging is a strong risk factor for colorectal cancer (CRC). It is well established that gut microbial dysbiosis can play a role in the etiology of CRC. Although the composition of the gut microbial community changes with age and is reported ...