B. thetaiotaomicron-derived acetic acid modulate immune microenvironment and tumor growth in hepatocellular carcinoma [0.03%]
B. 由thetaiotaomicron衍生的醋酸调节肝细胞癌中的免疫微环境和肿瘤生长
Hongbin Ma,Liang Yang,Yingchao Liang et al.
Hongbin Ma et al.
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, and emerging evidence suggests that the gut microbiota may play a role in its development and progression. In this study, the association between B. theta...
A synthetic microbial consortium protects against obesity by regulating vitamin B6 metabolism [0.03%]
合成微生物丛通过调节维生素B6代谢防止肥胖
Xiuzhao Chen,Mengxue Gao,Lina Wang et al.
Xiuzhao Chen et al.
Constructing synthetic microbial consortia is a challenging task but holds enormous potential for various applications. Our previous droplet-based microfluidic approach allowed for the isolation of bacteria that could utilize metabolites fr...
Meta-analysis reveals obesity associated gut microbial alteration patterns and reproducible contributors of functional shift [0.03%]
荟萃分析揭示与肥胖相关的肠道微生物变化模式和功能性转移的可重复性贡献因素
Deep Chanda,Debojyoti De
Deep Chanda
The majority of cohort-specific studies associating gut microbiota with obesity are often contradictory; thus, the replicability of the signature remains questionable. Moreover, the species that drive obesity-associated functional shifts an...
Meta-Analysis
Gut microbes. 2024 Jan-Dec;16(1):2304900. DOI:10.1080/19490976.2024.2304900 2024
Gut microbiota-driven metabolic alterations reveal gut-brain communication in Alzheimer's disease model mice [0.03%]
肠道菌群驱动的代谢变化揭示了阿尔茨海默病模型小鼠中肠-脑通讯的存在
Yijing Chen,Yinhu Li,Yingying Fan et al.
Yijing Chen et al.
The gut microbiota (GM) and its metabolites affect the host nervous system and are involved in the pathogeneses of various neurological diseases. However, the specific GM alterations under pathogenetic pressure and their contributions to th...
The contribution of age-related changes in the gut-brain axis to neurological disorders [0.03%]
肠道-大脑轴年龄相关变化对神经系统疾病的影响
Romeesa Khan,Claudia M Di Gesù,Juneyoung Lee et al.
Romeesa Khan et al.
Trillions of microbes live symbiotically in the host, specifically in mucosal tissues such as the gut. Recent advances in metagenomics and metabolomics have revealed that the gut microbiota plays a critical role in the regulation of host im...
Tunable control of B. infantis abundance and gut metabolites by co-administration of human milk oligosaccharides [0.03%]
通过共给药人乳寡糖来调节B.infantis的丰度和肠道代谢物
Abigail L Reens,Casey M Cosetta,Russell Saur et al.
Abigail L Reens et al.
Precision engineering of the gut microbiome holds promise as an effective therapeutic approach for diseases associated with a disruption in this microbial community. Engrafting a live biotherapeutic product (LBP) in a predictable, controlla...
Disruption of gut barrier integrity and host-microbiome interactions underlie MASLD severity in patients with type-2 diabetes mellitus [0.03%]
肠道屏障完整性破坏和宿主-微生物群相互作用是2型糖尿病患者MASLD严重程度的基础
R Forlano,L Martinez-Gili,P Takis et al.
R Forlano et al.
Aberration of the "gut-liver axis" contributes to the development and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we use multi-omics to analyze the gut microbiota composition and metabolic profile ...
Evaluation of gut microbiota predictive potential associated with phenotypic characteristics to identify multifactorial diseases [0.03%]
评估与表型特征相关的肠道微生物群预测潜能以识别多因素疾病
Danielle Cristina Fonseca,Ilanna Marques Gomes da Rocha,Bianca Depieri Balmant et al.
Danielle Cristina Fonseca et al.
Gut microbiota has been implicated in various clinical conditions, yet the substantial heterogeneity in gut microbiota research results necessitates a more sophisticated approach than merely identifying statistically different microbial tax...
Influence of age, socioeconomic status, and location on the infant gut resistome across populations [0.03%]
年龄、社会经济地位和地理位置对跨人群婴儿肠道耐受基因组的影响
Dhrati V Patangia,Ghjuvan Grimaud,Shaopu Wang et al.
Dhrati V Patangia et al.
Antibiotic resistance is a growing global concern, with many ecological niches showing a high abundance of antibiotic resistance genes (ARGs), including the human gut. With increasing indications of ARGs in infants, this study aims to inves...
Incorporating metabolic activity, taxonomy and community structure to improve microbiome-based predictive models for host phenotype prediction [0.03%]
整合代谢活性、分类学和群落结构以提高基于微生物组的宿主表型预测模型
Mahsa Monshizadeh,Yuzhen Ye
Mahsa Monshizadeh
We developed MicroKPNN, a prior-knowledge guided interpretable neural network for microbiome-based human host phenotype prediction. The prior knowledge used in MicroKPNN includes the metabolic activities of different bacterial species, phyl...