Citrobacter rodentium possesses a functional type II secretion system necessary for successful host infection [0.03%]
Citrobacter rodentium拥有功能性II型分泌系统，这是成功感染宿主的必要条件
Z Krekhno,S E Woodward,A Serapio-Palacios et al.
Z Krekhno et al.
Infectious diarrheal diseases are the third leading cause of mortality in young children, many of which are driven by Gram-negative bacterial pathogens. To establish successful host infections these pathogens employ a plethora of virulence ...
Gut microbiota-derived indole compounds attenuate metabolic dysfunction-associated steatotic liver disease by improving fat metabolism and inflammation [0.03%]
肠道微生物产生的吲哚化合物通过改善脂肪代谢和炎症来减轻与代谢功能障碍相关的脂肪性肝病
Byeong Hyun Min,Shivani Devi,Goo Hyun Kwon et al.
Byeong Hyun Min et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, and its prevalence has increased worldwide in recent years. Additionally, there is a close relationship between MASLD and gut microbi...
Fungal signature differentiates alcohol-associated liver disease from nonalcoholic fatty liver disease [0.03%]
真菌特征区分酒精相关肝病和非酒精性脂肪肝病
Greta Viebahn,Phillipp Hartmann,Sonja Lang et al.
Greta Viebahn et al.
The fungal microbiota plays an important role in the pathogenesis of alcohol-associated liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD). In this study, we aimed to compare changes of the fecal fungal microbiota between pati...
Direct evidence of host-mediated glycosylation of NleA and its dependence on interaction with the COPII complex [0.03%]
宿主介导的NleA糖基化及其与COPII复合体相互作用依赖性的直接证据
Lindsay Burns,François Le Mauff,Samantha Gruenheid
Lindsay Burns
Non-LEE-encoded Effector A (NleA) is a type III secreted effector protein of enterohaemorrhagic and enteropathogenic Escherichia coli as well as the related mouse pathogen Citrobacter rodentium. NleA translocation into host cells is essenti...
Longitudinal analysis of the gut microbiome in adolescent patients with anorexia nervosa: microbiome-related factors associated with clinical outcome [0.03%]
厌食症青少年患者肠道微生物的纵向分析：与临床结果相关的微生物因素
Nadia Andrea Andreani,Arunabh Sharma,Brigitte Dahmen et al.
Nadia Andrea Andreani et al.
There is mounting evidence regarding the role of gut microbiota in anorexia nervosa (AN). Previous studies have reported that patients with AN show dysbiosis compared to healthy controls (HCs); however, the underlying mechanisms are unclear...
Anti-S-layer monoclonal antibodies impact Clostridioides difficile physiology [0.03%]
抗S层单克隆抗体影响艰难梭菌的生理状态
Lise Hunault,Emile Auria,Patrick England et al.
Lise Hunault et al.
Clostridioides difficile (C. difficile), a gram-positive anaerobic and spore-forming bacterium, is the leading cause of nosocomial antibiotic-associated diarrhea in adults which is characterized by high levels of recurrence and mortality. S...
A gut aging clock using microbiome multi-view profiles is associated with health and frail risk [0.03%]
利用微生物多视角谱分析的老化生物钟与健康及衰弱风险相关
Hongchao Wang,Yutao Chen,Ling Feng et al.
Hongchao Wang et al.
Age-related changes in the microbiome have been reported in previous studies; however, direct evidence for their association with frailty is lacking. Here, we introduce biological age based on gut microbiota (gAge), an integrated prediction...
Antibiotic-induced gut dysbiosis elicits gut-brain axis relevant multi-omic signatures and behavioral and neuroendocrine changes in a nonhuman primate model [0.03%]
抗生素诱导的肠道菌群失调引起与肠道-大脑轴相关的多重组学特征及非人灵长类模型的行为和神经内分泌变化
Shivdeep S Hayer,Mackenzie Conrin,Jeffrey A French et al.
Shivdeep S Hayer et al.
Emerging evidence indicates that antibiotic-induced dysbiosis can play an etiological role in the pathogenesis of neuropsychiatric disorders. However, most of this evidence comes from rodent models. The objective of this study was to evalua...
Bacteroides thetaiotaomicron ameliorates mouse hepatic steatosis through regulating gut microbial composition, gut-liver folate and unsaturated fatty acids metabolism [0.03%]
通过调节肠道微生物组成以及肠道-肝脏叶酸和不饱和脂肪酸的代谢，Bacteroides thetaiotaomicron改善了小鼠肝内脂质沉积问题
Hu Li,Xue-Kai Wang,Mei Tang et al.
Hu Li et al.
Gut microbiota plays an essential role in the progression of nonalcoholic fatty liver disease (NAFLD), making the gut-liver axis a potential therapeutic strategy. Bacteroides genus, the enriched gut symbionts, has shown promise in treating ...
Microbial stars: shedding light on gut microbes' role in insulin resistance and innovative diabetes therapies [0.03%]
微生物明星：揭示肠道微生物在胰岛素抵抗和创新糖尿病疗法中作用
Jinwei Zhang
Jinwei Zhang
The role of gut microbiota in insulin resistance (IR), Metabolic Syndrome (MetS), and Type 2 Diabetes Mellitus (T2DM) is rapidly gaining recognition. However, the mechanisms and implications of gut bacteria in these conditions remain enigma...