Repeated (S)-ketamine administration ameliorates the spatial working memory impairment in mice with chronic pain: role of the gut microbiota-brain axis [0.03%]
反复应用(S)-氯胺酮改善慢性疼痛小鼠的空间工作记忆障碍：肠道菌群-脑轴的作用
Yubin Jiang,Xingming Wang,Jiawei Chen et al.
Yubin Jiang et al.
Chronic pain is commonly linked with diminished working memory. This study explores the impact of the anesthetic (S)-ketamine on spatial working memory in a chronic constriction injury (CCI) mouse model, focusing on gut microbiome. We found...
Elena F Verdu,Stephen Vanner
Elena F Verdu
Prescription opioids induced microbial dysbiosis worsens severity of chronic pancreatitis and drives pain hypersensitivity [0.03%]
处方类阿片诱导的微生物群失调会加重慢性胰腺炎的严重程度并导致疼痛超敏反应
Kousik Kesh,Junyi Tao,Nillu Ghosh et al.
Kousik Kesh et al.
Opioids, such as morphine and oxycodone, are widely used for pain management associated with chronic pancreatitis (CP); however, their impact on the progression and pain sensitivity of CP has never been evaluated. This report investigates t...
Ayelet Gur Arie,Itamar Toren,Rotem Hadar et al.
Ayelet Gur Arie et al.
Spinal cord injury (SCI) is a devastating event that significantly changes daily function and quality of life and is linked to bowel and bladder dysfunction and frequent antibiotic treatment. We aimed to study the composition of the gut mic...
Gut microbiota modulate CD8+ T cell immunity in gastric cancer through Butyrate/GPR109A/HOPX [0.03%]
肠道菌群通过丁酸/GPR109A/HOPX轴调节胃癌中的CD8+ T细胞免疫功能
Xiang Yu,Jinzhou Ou,Lingzhi Wang et al.
Xiang Yu et al.
The gut microbiota and Short-chain fatty acids (SCFAs) can influence the progression of diseases, yet the role of these factors on gastric cancer (GC) remains uncertain. In this work, the analysis of the gut microbiota composition and SCFA ...
Integrated multi-omics reveal gut microbiota-mediated bile acid metabolism alteration regulating immunotherapy responses to anti-α4β7-integrin in Crohn's disease [0.03%]
综合多组学揭示肠道微生物群介导的胆汁酸代谢改变调节克罗恩病抗α4β7整合素免疫治疗反应过程
Bing Han,Daiyuan Tang,Xiaodan Lv et al.
Bing Han et al.
Gut microbiota and related metabolites are both crucial factors that significantly influence how individuals with Crohn's disease respond to immunotherapy. However, little is known about the interplay among gut microbiota, metabolites, Croh...
Phocaeicola vulgatus alleviates diet-induced metabolic dysfunction-associated steatotic liver disease progression by downregulating histone acetylation level via 3-HPAA [0.03%]
通过3-HPAA下调组蛋白乙酰化水平，Phocaeicola vulgatus缓解饮食引起的代谢功能障碍相关脂肪性肝病进展
Shengxi Jin,Peng Chen,Jing Yang et al.
Shengxi Jin et al.
Diet-induced metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder with limited effective interventions available. A novel approach to address this issue is through gut microbiota-based therapy. ...
Microbiome function and neurodevelopment in Black infants: vitamin B12 emerges as a key factor [0.03%]
黑人婴儿的微生物组功能和神经发育：维生素B12成为关键因素
Kaitlyn Oliphant,Wilfredo Cruz Ayala,Rimma Ilyumzhinova et al.
Kaitlyn Oliphant et al.
The early life gut microbiome affects the developing brain, and therefore may serve as a target to support neurodevelopment of children living in stressful and under-resourced environments, such as Black youth living on the South Side of Ch...
Effects of breastfeeding on children's gut colonization with multidrug-resistant Enterobacterales in peri-urban Lima, Peru [0.03%]
母乳喂养对秘鲁利马城郊儿童肠道多重耐药肠杆菌科定植的影响
Maya L Nadimpalli,Luismarcelo Rojas Salvatierra,Subhra Chakraborty et al.
Maya L Nadimpalli et al.
Children living in low-resource settings are frequently gut-colonized with multidrug-resistant bacteria. We explored whether breastfeeding may protect against children's incident gut colonization with extended-spectrum beta-lactamase-produc...
Exploring substrate-microbe interactions: a metabiotic approach toward developing targeted synbiotic compositions [0.03%]
探索底物与微生物的相互作用：开发靶向合生元配方的代谢生物方法
Bodo Speckmann,Ellen Ehring,Jiaying Hu et al.
Bodo Speckmann et al.
Gut microbiota is an important modulator of human health and contributes to high inter-individual variation in response to food and pharmaceutical ingredients. The clinical outcomes of interventions with prebiotics, probiotics, and synbioti...