Mariana Santos Cruz,Joseph Tintelnot,Nicola Gagliani
Mariana Santos Cruz
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This is due to the fact that most cases are only diagnosed at an advanced and palliative disease stage, and there is a high incidence of therapy resistanc...
Advancing lifelong precision medicine for cardiovascular diseases through gut microbiota modulation [0.03%]
通过调节肠道微生物群推动心血管疾病的终身精准医学发展
Bozhong Shi,Haoyu Li,Xiaomin He
Bozhong Shi
The gut microbiome is known as the tenth system of the human body that plays a vital role in the intersection between health and disease. The considerable inter-individual variability in gut microbiota poses both challenges and great prospe...
Regulation of colonic neuropeptide Y expression by the gut microbiome in patients with ulcerative colitis and its association with anxiety- and depression-like behavior in mice [0.03%]
肠道菌群通过调节结肠神经肽Y的表达影响溃疡性结肠炎患者焦虑和抑郁样行为的研究
Min-Kyung Joo,Jae-Won Lee,Jeong-Hwa Woo et al.
Min-Kyung Joo et al.
Patients with inflammatory bowel disease (IBD), including ulcerative colitis (UC), show an increased incidence of anxiety and depression; however, the association between UC-associated psychiatric disorders and the gut microbiota is unclear...
The intestinal microbiome of inflammatory bowel disease across the pediatric age range [0.03%]
整个儿童年龄范围内炎症性肠病的肠道微生物群
Máire A Conrad,Kyle Bittinger,Yue Ren et al.
Máire A Conrad et al.
Dysbiosis is associated with pediatric and adult-onset inflammatory bowel disease (IBD), but the role of dysbiosis and the microbiome in very early onset IBD (VEO-IBD) has not yet been described. Here, we aimed to demonstrate the impact of ...
Chemotherapy-induced microbiota exacerbates the toxicity of chemotherapy through the suppression of interleukin-10 from macrophages [0.03%]
化疗诱导的微生物群通过抑制巨噬细胞中的白细胞介素-10来加剧化疗的毒性
Zhen He,Hongyu Xie,Haoyang Xu et al.
Zhen He et al.
The gut microbiota has been shown to influence the efficacy and toxicity of chemotherapy, thereby affecting treatment outcomes. Understanding the mechanism by which microbiota affects chemotherapeutic toxicity would have a profound impact o...
S-amlodipine induces liver inflammation and dysfunction through the alteration of intestinal microbiome in a rat model [0.03%]
S-氨氯地平通过改变大鼠模型的肠道微生物群诱导肝脏炎症和功能障碍
Xinxin Liu,Hui Fang,Liuzhu Pan et al.
Xinxin Liu et al.
S-amlodipine, a commonly prescribed antihypertensive agent, is widely used in clinical settings to treat hypertension. However, the potential adverse effects of long-term S-amlodipine treatment on the liver remain uncertain, given the cauti...
The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk [0.03%]
幽门螺杆菌的细胞毒素相关基因病理岛作为胃癌的风险因素
Sirena C Tran,Kaeli N Bryant,Timothy L Cover
Sirena C Tran
Helicobacter pylori strains can be broadly classified into two groups based on whether they contain or lack a chromosomal region known as the cag pathogenicity island (cag PAI). Colonization of the human stomach with cag PAI-positive strain...
B. longum CKD1 enhances the efficacy of anti-diabetic medicines through upregulation of IL- 22 response in type 2 diabetic mice [0.03%]
B. longum CKD1通过上调IL-22反应增强2型糖尿病小鼠的抗糖尿病药物疗效
Won Jun Kim,Bum Ju Kil,Chaewon Lee et al.
Won Jun Kim et al.
The gut microbiota plays a pivotal role in metabolic disorders, notably type 2 diabetes mellitus (T2DM). In this study, we investigated the synergistic potential of combining the effects of Bifidobacterium longum NBM7-1 (CKD1) with anti-dia...
The biotherapeutic Clostridium butyricum MIYAIRI 588 strain potentiates enterotropism of Rorγt+Treg and PD-1 blockade efficacy [0.03%]
生物治疗药物MIYAIRI 588型丁酸梭菌可增强Rorγt+Treg的肠嗜性和PD-1阻断疗效
Thomas Paz Del Socorro,Kentaro Oka,Olivier Boulard et al.
Thomas Paz Del Socorro et al.
Immune checkpoint inhibitors (ICI) have been positioned as a standard of care for patients with advanced non-small-cell lung carcinomas (NSCLC). A pilot clinical trial has reflected optimistic association between supplementation with Clostr...
A tailored series of engineered yeasts for the cell-dependent treatment of inflammatory bowel disease by rational butyrate supplementation [0.03%]
通过合理补充丁酸盐进行细胞依赖性炎症性肠病治疗的工程酵母菌株系列化设计
Jiahao Wu,He Huang,Lina Wang et al.
Jiahao Wu et al.
Intestinal microbiota dysbiosis and metabolic disruption are considered essential characteristics in inflammatory bowel disorders (IBD). Reasonable butyrate supplementation can help patients regulate intestinal flora structure and promote m...