Gut bacteriophages induce specific-reprogramming of macrophages to generate a protective innate immunity response to lipopolysaccharide exposure [0.03%]
肠道噬菌体通过特异性重编程巨噬细胞来产生对脂多糖暴露的保护性先天免疫反应
Xiang Hou,Huiyan Ding,Heye Wang et al.
Xiang Hou et al.
Macrophages play essential roles in generating a tolerogenic resident environment, but the interactions between bacteriophages and their action in macrophage tolerance memory remain unknown. Here, we find that gut bacteriophage exposure in ...
"Microbial and immune modulation by 2'-fucosyllactose supplementation during gestation: a strategy to prevent food allergies" [0.03%]
“通过妊娠期间的2'-岩藻糖基乳糖补充调节微生物和免疫系统：预防食物过敏的策略”
Carole Brosseau,Anaïs Rousseaux,Marine Le Romancer et al.
Carole Brosseau et al.
Food allergies are linked to dysfunction in intestinal microbiota, the immune system and the intestinal epithelial barrier, leading to immune tolerance failure at birth. We hypothesized that a diet enriched with a Human Milk Oligosaccharide...
BroadAMP-GPT: AI-Driven generation of broad-spectrum antimicrobial peptides for combating multidrug-resistant ESKAPE pathogens [0.03%]
广谱抗菌肽生成算法BroadAMP-GPT：对抗多重耐药ESKAPE病原体
Yanru Li,Xianghan Xu,Xiaohui Zhang et al.
Yanru Li et al.
Antimicrobial peptides (AMPs) are promising candidates to address the global antimicrobial resistance crisis, yet their traditional design remains labor-intensive and inefficient. Here, we developed BroadAMP-GPT, an integrated computational...
Valentina Arrè,Roberto De Luca,Stella Mrmić et al.
Valentina Arrè et al.
Gastrointestinal (GI) inflammation and malignancies arise from complex interactions between the host's immune responses and microbial pathogens. Epstein-Barr virus (EBV), Helicobacter pylori (H. pylori), and Severe acute respiratory syndrom...
Microbiome compositional changes and clonal engraftment in a phase 3 trial of fecal microbiota, live-jslm for recurrent Clostridioides difficile infection [0.03%]
一项有关艰难梭菌感染复发患者3期临床试验中，粪便微生物组组成变化及克隆植入的研究
Josh Claypool,Gustav Lindved,Pernille Neve Myers et al.
Josh Claypool et al.
Live microbiota therapies have shown promise in many gastrointestinal diseases, including in the prevention of recurrent Clostridioides difficile infections (rCDI); however, frameworks for their pharmacokinetic and pharmacodynamic analysis ...
Clinical Trial
Gut microbes. 2025 Dec;17(1):2520412. DOI:10.1080/19490976.2025.2520412 2025
Staphylococcus haemolyticus is a reservoir of antibiotic resistance genes in the preterm infant gut [0.03%]
凝固酶阴性葡萄球菌胎粪肠球菌是早产儿肠道中耐药基因的储存库
Lisa E Lamberte,Elizabeth M Darby,Raymond Kiu et al.
Lisa E Lamberte et al.
Staphylococcus haemolyticus is an important cause of sepsis in preterm infants, with gut colonization being recognized as a risk factor for infection. To better understand the diversity of S. haemolyticus among preterm infants, we generated...
Bacteria enable tolerance to bile salt exposure in an immune-competent human intestinal model [0.03%]
肠道细菌使免疫健全的人肠模型能够耐受胆盐暴露
Yuan Li,Chia-Ming Wang,Peng Zhao et al.
Yuan Li et al.
Bile salts (BS) are known to be highly important in modulating bacteria-host crosstalk in the gut, serving as essential signaling molecules governing intestinal homeostasis. However, understanding of this crosstalk is limited by challenges ...
Being a better version of yourself: genetically engineered probiotic bacteria as host defense enhancers in the control of intestinal pathogens [0.03%]
成为更好的自己：作为宿主防御增强剂控制肠道病原体的基因工程益生菌细菌
Ewa Carolak,Joanna Czajkowska,Adrianna Stypułkowska et al.
Ewa Carolak et al.
Intestinal pathogens pose a significant global health burden, and traditional antibiotic treatments often disrupt the beneficial gut microbiota that plays a crucial role in maintaining host health through pathogen prevention and immune regu...
The Microbial Anti-Inflammatory Molecule (MAM) is a key protein processed and exported to Faecalibacterium duncaniae envelope [0.03%]
黏附促进抗炎分子(MAM)是Faecalibacteriumduncani加工并分泌到细菌外被膜的关键蛋白
Thaís Vilela Rodrigues,Sylvain Marthey,Sandrine Auger et al.
Thaís Vilela Rodrigues et al.
MAM (Microbial-Anti-Inflammatory Molecule) is a key effector protein with anti-inflammatory properties in Faecalibacterium duncaniae, a critical human gut microbiota species. Despite its importance, MAM function and molecular features remai...
Donor-centric administration of the stool donor program is vital to its feasibility and patient safety [0.03%]
以捐献者为中心的管理是粪便捐献项目可行性和患者安全性的关键因素
Amanda J Kabage,Parker J Haselhorst,Alexander Khoruts
Amanda J Kabage
Human stool-based products composed of fecal microbiota are a new frontier of medical therapeutics development. The development of standardized manufacturing protocols of donor microbiota has transformed fecal microbiota transplantation (FM...