Shotgun metagenomics and systemic targeted metabolomics highlight indole-3-propionic acid as a protective gut microbial metabolite against influenza infection [0.03%]
宏基因组霰弹枪测序和系统靶向代谢物研究强调吲哚-3-丙酸是抵御流感感染的保护性肠道代谢物
Séverine Heumel,Vinícius de Rezende Rodovalho,Charlotte Urien et al.
Séverine Heumel et al.
The gut-to-lung axis is critical during respiratory infections, including influenza A virus (IAV) infection. In the present study, we used high-resolution shotgun metagenomics and targeted metabolomic analysis to characterize influenza-asso...
Modulation of chronic obstructive pulmonary disease progression by antioxidant metabolites from Pediococcus pentosaceus: enhancing gut probiotics abundance and the tryptophan-melatonin pathway [0.03%]
戊糖片球菌的抗氧化代谢物通过增强肠道益生菌和色氨酸-褪黑激素通路来调节慢性阻塞性肺疾病的进展
Yiting Liu,Longjie Li,Jing Feng et al.
Yiting Liu et al.
Chronic obstructive pulmonary disease (COPD), a condition primarily linked to oxidative stress, poses significant health burdens worldwide. Recent evidence has shed light on the association between the dysbiosis of gut microbiota and COPD, ...
A modified Mediterranean-style diet enhances brain function via specific gut-microbiome-brain mechanisms [0.03%]
一种改良的地中海饮食通过特定的肠-微生物组-大脑机制改善脑功能
Gwoncheol Park,Saurabh Kadyan,Nathaniel Hochuli et al.
Gwoncheol Park et al.
Alzheimer's disease (AD) is a debilitating brain disorder with rapidly mounting prevalence worldwide, yet no proven AD cure has been discovered. Using a multi-omics approach in a transgenic AD mouse model, the current study demonstrated the...
IgA-mediated control of host-microbial interaction during weaning reaction influences gut inflammation [0.03%]
断奶反应期间IgA介导的宿主-微生物相互作用控制影响肠道炎症
Wenjie Tang,Yusen Wei,Zhixiang Ni et al.
Wenjie Tang et al.
The mechanisms of how host-microbe mutualistic relationships are established at weaning contingently upon B-cell surveillance remain inadequately elucidated. We found that CD138+ plasmacyte (PC)-mediated promotion of IgA response regulates ...
Bifidobacterium alleviate metabolic disorders via converting methionine to 5'-methylthioadenosine [0.03%]
乳双歧杆菌通过甲硫氨酸转化为5'-甲硫腺苷来改善代谢紊乱
Qiang Lyu,Rou-An Chen,Hsiao-Li Chuang et al.
Qiang Lyu et al.
Dietary patterns and corresponding gut microbiota profiles are associated with various health conditions. A diet rich in polyphenols, primarily plant-based, has been shown to promote the growth of probiotic bacteria in the gastrointestinal ...
A metagenomic prospective cohort study on gut microbiome composition and clinical infection in small bowel transplantation [0.03%]
移植物肠道菌群组成与临床感染的前瞻性队列研究中的宏基因组学分析
Archana Madhav,Rachel Bousfield,Joana Pereira-Dias et al.
Archana Madhav et al.
Two-thirds of small-bowel transplantation (SBT) recipients develop bacteremia, with the majority of infections occurring within 3 months post-transplant. Sepsis-related mortality occurs in 31% of patients and is commonly caused by bacteria ...
Bile acid profiling as an effective biomarker for staging in pediatric inflammatory bowel disease [0.03%]
胆酸谱作为儿童炎症性肠病分期的有效生物标志物
Wei Chen,Daosheng Wang,Xing Deng et al.
Wei Chen et al.
Rapid and accurate clinical staging of pediatric patients with inflammatory bowel disease (IBD) is crucial to determine the appropriate therapeutic approach. This study aimed to identify effective, convenient biomarkers for staging IBD in p...
Maternal smoking during pregnancy increases the risk of gut microbiome-associated childhood overweight and obesity [0.03%]
孕期母亲吸烟会增加儿童期与肠道微生物群相关的超重和肥胖的风险
Ye Peng,Hein M Tun,Siew C Ng et al.
Ye Peng et al.
Childhood obesity is linked to maternal smoking during pregnancy. Gut microbiota may partially mediate this association and could be potential targets for intervention; however, its role is understudied. We included 1,592 infants from the C...
Gut microbiota-palmitoleic acid-interleukin-5 axis orchestrates benzene-induced hematopoietic toxicity [0.03%]
肠道菌群-棕榈油酸-白细胞介素5轴调控苯诱导的血液毒性
Lei Zhang,Ziyan Liu,Wei Zhang et al.
Lei Zhang et al.
Due to the annual increase in its production and consumption in occupational environments, the adverse blood outcomes caused by benzene are of concern. However, the mechanism of benzene-induced hematopoietic damage remains elusive. Here, we...
A metatranscriptomics strategy for efficient characterization of the microbiome in human tissues with low microbial biomass [0.03%]
低微生物生物量人体组织中微生物群的有效表征的宏转录组策略
Joana Pereira-Marques,Rui M Ferreira,Ceu Figueiredo
Joana Pereira-Marques
The high background of host RNA poses a major challenge to metatranscriptome analysis of human samples. Hence, metatranscriptomics has been mainly applied to microbe-rich samples, while its application in human tissues with low ratio of mic...