Pathogen-specific alterations in intestinal microbiota precede urinary tract infections in preterm infants: a longitudinal case-control study [0.03%]
病原体特异性肠道微生物组的变化先于早产儿的泌尿道感染：一项纵向病例对照研究
Luyang Hong,Yihuang Huang,Junyan Han et al.
Luyang Hong et al.
Urinary tract infections (UTIs) are among the most common late-onset infections in preterm infants, characterized by nonspecific symptoms and a pathogenic spectrum that diverges from that of term infants and older children, which present un...
The effects of antibiotic exposures on the gut resistome during hematopoietic cell transplantation in children [0.03%]
儿童造血干细胞移植中抗生素暴露对肠道耐药菌群的影响
Sarah M Heston,Rebecca R Young,Kirsten Jenkins et al.
Sarah M Heston et al.
Antibiotic resistance is a global threat driven primarily by antibiotic use. We evaluated the effects of antibiotic exposures on the gut microbiomes and resistomes of children at high risk of colonization by antibiotic-resistant bacteria. W...
Gastrointestinal signals in supplemented media reveal a role in adherence for the Shigella flexneri sap autotransporter gene [0.03%]
补充培养基中的胃肠道信号表明sap自转运蛋白基因在志贺氏菌粘附中发挥作用
Yrvin León,Raphael Honigsberg,David A Rasko et al.
Yrvin León et al.
Shigella flexneri causes severe diarrheal disease worldwide. While many aspects of pathogenesis have been elucidated, significant knowledge gaps remain regarding the role of putative chromosomally-encoded virulence genes. The uncharacterize...
Integrated analysis of gut metabolome, microbiome, and brain function reveal the role of gut-brain axis in longevity [0.03%]
整合分析肠道代谢组、微生物组和脑功能发现肠-脑轴在长寿中的作用
Bin Jiao,Ziyu Ouyang,Qianqian Liu et al.
Bin Jiao et al.
The role of microbiota-gut-brain axis in modulating longevity remains undetermined. Here, we performed a multiomics analysis of gut metagenomics, gut metabolomics, and brain functional near-infrared spectroscopy (fNIRS) in a cohort of 164 p...
Oral pathobiont Klebsiella chaperon usher pili provide site-specific adaptation for the inflamed gut mucosa [0.03%]
口腔条件致病菌克雷伯菌的伴侣蛋白-usher型菌毛能够特异性适应肠道炎症黏膜微环境
Yijie Guo,Sho Kitamoto,Gustavo Caballero-Flores et al.
Yijie Guo et al.
The ectopic gut colonization by orally derived pathobionts has been implicated in the pathogenesis of various gastrointestinal diseases, including inflammatory bowel disease (IBD). For example, gut colonization by orally derived Klebsiella ...
From animal models to gut-on-chip: the challenging journey to capture inter-individual variability in chronic digestive disorders [0.03%]
从动物模型到肠道芯片：捕捉慢性消化系统疾病个体间差异的艰难历程
Aicha Kriaa,Vincent Mariaule,Charlotte De Rudder et al.
Aicha Kriaa et al.
Chronic digestive disorders are of increasing incidence worldwide with expensive treatments and no available cure. Available therapeutic schemes mainly rely on symptom relief, with large degrees of variability in patients' response to such ...
Intestinal microbiota modulates neuroinflammatory response and brain injury after neonatal hypoxia-ischemia [0.03%]
肠道菌群调节新生儿缺氧缺血后的神经炎症反应及脑损伤
Alexander Drobyshevsky,Sylvia Synowiec,Ivan Goussakov et al.
Alexander Drobyshevsky et al.
Premature infants lack a normal intestinal microbial community and also at risk of perinatal hypoxic-ischemic (HI) brain injury, which is considered to be one of the major factors for motor, sensory, and cognitive deficits. We hypothesized ...
Fusobacterium nucleatum induces chemoresistance in colorectal cancer by inhibiting pyroptosis via the Hippo pathway [0.03%]
脆弱拟杆菌通过Hippo信号通路抑制焦亡从而诱导结直肠癌产生耐药性
Ni Wang,Lu Zhang,Xiao-Xu Leng et al.
Ni Wang et al.
Chemotherapy resistance is one of the main reasons for the poor prognosis of colorectal cancer (CRC). Moreover, dysbiosis of gut bacteria was found to be a specific environmental risk factor. In this study, enrichment of F. nucleatum was el...
Transplant of microbiota from Crohn's disease patients to germ-free mice results in colitis [0.03%]
将克罗恩病患者的微生物群移植到无菌小鼠体内导致结肠炎
Irshad Ali Sheikh,Jared Bianchi-Smak,Daniel Laubitz et al.
Irshad Ali Sheikh et al.
Although the role of the intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD) is beyond debate, attempts to verify the causative role of IBD-associated dysbiosis have been limited to reports of promoting the disease...
Indole-3-acetic acid alleviates DSS-induced colitis by promoting the production of R-equol from Bifidobacterium pseudolongum [0.03%]
吲哚-3-乙酸通过促进伪长双歧杆菌产生R- equol来缓解DSS诱导的结肠炎
Miaomiao Li,Xue Han,Lijun Sun et al.
Miaomiao Li et al.
Background: Inflammatory bowel disease (IBD) is characterized by immune-mediated, chronic inflammation of the intestinal tract. The occurrence of IBD is driven by the complex interactions of multiple factors. The objectiv...