Pathogenesis and therapeutic opportunities of gut microbiome dysbiosis in critical illness [0.03%]
肠道菌群紊乱在重症患者发病机制及治疗中的作用
Nicole A Cho,Kathryn Strayer,Breenna Dobson et al.
Nicole A Cho et al.
For many years, it has been hypothesized that pathological changes to the gut microbiome in critical illness is a driver of infections, organ dysfunction, and other adverse outcomes in the intensive care unit (ICU). The advent of contempora...
The use of probiotics and prebiotics in decolonizing pathogenic bacteria from the gut; a systematic review and meta-analysis of clinical outcomes [0.03%]
益生菌和益生元在根除病原细菌方面的应用；临床结果的系统评价与荟萃分析
Md Nannur Rahman,Nilakshi Barua,Martha C F Tin et al.
Md Nannur Rahman et al.
Repeated exposure to antibiotics and changes in the diet and environment shift the gut microbial diversity and composition, making the host susceptible to pathogenic infection. The emergence and ongoing spread of AMR pathogens is a challeng...
Fecal microbiota transplantation significantly improved respiratory failure of amyotrophic lateral sclerosis [0.03%]
粪便微生物移植显著改善了肌萎缩侧索硬化患者的呼吸功能衰竭
Jingshuang Yan,Huixin Chen,Yan Zhang et al.
Jingshuang Yan et al.
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that leads to respiratory failure, and eventually death. However, there is a lack of effective treatments for ALS. Here we report the results of fecal microbiota...
Prevotella copri exhausts intrinsic indole-3-pyruvic acid in the host to promote breast cancer progression: inactivation of AMPK via UHRF1-mediated negative regulation [0.03%]
Prevotella copri通过UHRF1介导的负向调控使宿主内的内源性吲哚-3-丙酮酸耗竭来促进乳腺癌进展：AMPK失活
Jiyan Su,Xiaojie Lin,Dan Li et al.
Jiyan Su et al.
Emerging evidence has revealed the novel role of gut microbiota in the development of cancer. The characteristics of function and composition in the gut microbiota of patients with breast cancer patients has been reported, however the detai...
Two-component system RstAB promotes the pathogenicity of adherent-invasive Escherichia coli in response to acidic conditions within macrophages [0.03%]
黏附侵袭型大肠杆菌两组分系统RstAB响应巨噬细胞内的酸性条件促进细菌致病性
Ting Yao,Xingmei Liu,Dan Li et al.
Ting Yao et al.
Adherent-invasive Escherichia coli (AIEC) strain LF82, isolated from patients with Crohn's disease, invades gut epithelial cells, and replicates in macrophages contributing to chronic inflammation. In this study, we found that RstAB contrib...
Novel approaches in IBD therapy: targeting the gut microbiota-bile acid axis [0.03%]
IBD治疗的新型方法：靶向肠道微生物群-胆汁酸轴
Yinping Pan,Haojie Zhang,Minghui Li et al.
Yinping Pan et al.
Inflammatory bowel disease (IBD) is a chronic and recurrent condition affecting the gastrointestinal tract. Disturbed gut microbiota and abnormal bile acid (BA) metabolism are notable in IBD, suggesting a bidirectional relationship. Specifi...
Haiqin Wu,Chunlong Mu,Laipeng Xu et al.
Haiqin Wu et al.
Intestinal stem cells (ISCs) play a pivotal role in gut physiology by governing intestinal epithelium renewal through the precise regulation of proliferation and differentiation. The gut microbiota interacts closely with the epithelium thro...
Two extracellular α-arabinofuranosidases are required for cereal-derived arabinoxylan metabolism by Bifidobacterium longum subsp. longum [0.03%]
两外切α-阿拉伯糖呋喃糖苷酶对长双歧杆菌亚种.longum分解谷物来源的阿拉伯木聚糖是必需的
Lisa Friess,Francesca Bottacini,Fionnuala M McAuliffe et al.
Lisa Friess et al.
Members of the genus Bifidobacterium are commonly found in the human gut and are known to utilize complex carbohydrates that are indigestible by the human host. Members of the Bifidobacterium longum subsp. longum taxon can metabolize variou...
Microbiota transplantation in restoring cesarean-related infant dysbiosis: a new frontier [0.03%]
微生物移植修复剖宫产相关的婴幼儿菌群失调：新前沿科技
Sina Liu,Xiaoxia Luo,Lepeng Zhou et al.
Sina Liu et al.
C-section is crucial in reducing maternal and neonatal mortality when medically indicated, but one of its side effects could be the disruption of vertical transmission of maternal-infant microbiota during delivery, potentially leading to gu...
Fecal transplant from vaginally seeded infants decreases intraabdominal adiposity in mice [0.03%]
从阴道接种的婴儿中获得的粪便移植可减少小鼠腹内脂肪量
Sivaranjani Namasivayam,Curtis Tilves,Hua Ding et al.
Sivaranjani Namasivayam et al.
Exposing C-section infants to the maternal vaginal microbiome, coined "vaginal seeding", partially restores microbial colonization. However, whether vaginal seeding decreases metabolic disease risk is unknown. Therefore, we assessed the eff...
Randomized Controlled Trial
Gut microbes. 2024 Jan-Dec;16(1):2353394. DOI:10.1080/19490976.2024.2353394 2024