Gut microbiota dysbiosis-related susceptibility to nontuberculous mycobacterial lung disease [0.03%]
肠道微生物群失调与非结核分枝杆菌肺病易感性的关系
Tzu-Lung Lin,Yen-Liang Kuo,Juo-Hsin Lai et al.
Tzu-Lung Lin et al.
The role of gut microbiota in host defense against nontuberculous mycobacterial lung disease (NTM-LD) was poorly understood. Here, we showed significant gut microbiota dysbiosis in patients with NTM-LD. Reduced abundance of Prevotella copri...
Gut microbiota depletion delays somatic peripheral nerve development and impairs neuromuscular junction maturation [0.03%]
肠道微生物群的耗竭会延迟周围神经的发育并影响神经肌肉接头的成熟
Matilde Cescon,Giovanna Gambarotta,Sonia Calabrò et al.
Matilde Cescon et al.
Gut microbiota is responsible for essential functions in human health. Several communication axes between gut microbiota and other organs via neural, endocrine, and immune pathways have been described, and perturbation of gut microbiota com...
Enhancing social behavior in an autism spectrum disorder mouse model: investigating the underlying mechanisms of Lactiplantibacillus plantarum intervention [0.03%]
利用乳植菌植物细菌干预改善自闭症小鼠模型的社会行为及潜在机制研究
Chih-Ming Chen,Chien-Chen Wu,Yebeen Kim et al.
Chih-Ming Chen et al.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder affecting over 1% of the global population. Individuals with ASD often exhibit complex behavioral conditions, including significant social difficulties and repetitive behaviors...
Microbial metabolite butyrate modulates granzyme B in tolerogenic IL-10 producing Th1 cells to regulate intestinal inflammation [0.03%]
肠道炎症调节中的微生物代谢物丁酸盐调控IL-10产生性T辅助1细胞中颗粒酶B的表达量
Wenjing Yang,Tianming Yu,Xia Liu et al.
Wenjing Yang et al.
CD4+ T cells play a critical role in regulating autoimmune diseases, and intestinal microbial metabolites control various immune responses. Granzyme B (GzmB)-producing CD4+ T cells have been recently reported to participate in the pathogene...
Antigenic operon fragmentation and diversification mechanism in Bacteroidota impacts gut metagenomics and pathobionts in Crohn's disease microlesions [0.03%]
拟杆菌门的抗原基因簇片段化和多样化机制影响克罗恩病微损伤部位的肠道宏基因组和条件致病菌
Nicholas C Bank,Vaidhvi Singh,Blake McCourt et al.
Nicholas C Bank et al.
Comensal Bacteroidota (Bacteroidota) and Enterobacteriacea are often linked to gut inflammation. However, the causes for variability of pro-inflammatory surface antigens that affect gut commensal/opportunistic dualism in Bacteroidota remain...
A novel Mediterranean diet-inspired supplement ameliorates cognitive, microbial, and metabolic deficits in a mouse model of low-grade inflammation [0.03%]
一种新型的地中海饮食补充剂改善低度炎症小鼠模型的认知、微生物和代谢缺陷
Matthew G Pontifex,Emily Connell,Gwenaelle Le Gall et al.
Matthew G Pontifex et al.
The Mediterranean diet (MD) and its bioactive constituents have been advocated for their neuroprotective properties along with their capacity to affect gut microbiota speciation and metabolism. Mediated through the gut brain axis, this modu...
The Fe-S cluster biosynthesis in Enterococcus faecium is essential for anaerobic growth and gastrointestinal colonization [0.03%]
粪肠球菌铁硫簇生物合成对厌氧生长和肠道定植是必需的
Linan Xu,Yajing Wu,Xiangpeng Yang et al.
Linan Xu et al.
The facultative anaerobic Gram-positive bacterium Enterococcus faecium is a ubiquitous member of the human gut microbiota. However, it has gradually evolved into a pathogenic and multidrug resistant lineage that causes nosocomial infections...
Evan Bradley,John Haran
Evan Bradley
The composition of the human gut microbiome has been observed to change over the course of an individual's life. From birth, it is shaped by mode of delivery, diet, environmental exposures, geographic location, exposures to medications, and...
Vaccines against extraintestinal pathogenic Escherichia coli (ExPEC): progress and challenges [0.03%]
针对肠外病原性大肠杆菌(ExPEC)的疫苗:进展和挑战
Ling Qiu,Dylan Chirman,Justin R Clark et al.
Ling Qiu et al.
The emergence of antimicrobial resistance (AMR) is a principal global health crisis projected to cause 10 million deaths annually worldwide by 2050. While the Gram-negative bacteria Escherichia coli is commonly found as a commensal microbe ...
Archaea influence composition of endoscopically visible ileocolonic biofilms [0.03%]
Archaea影响内镜可见回结肠生物膜的组成
Elisabeth Orgler,Maximilian Baumgartner,Stefanie Duller et al.
Elisabeth Orgler et al.
The gut microbiota has been implicated as a driver of irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Recently we described, mucosal biofilms, signifying alterations in microbiota composition and bile acid (BA) metaboli...