Chloe Herman,Bridget M Barker,Thais F Bartelli et al.
Chloe Herman et al.
Fecal Microbiota Transplant (FMT) is a treatment for recurrent Clostridium difficile infections and is being explored for other clinical applications, from alleviating digestive and neurological disorders, to restoring microbiomes impacted ...
Jerome Prusa,Mark G Gorelik,Kevin S Blake et al.
Jerome Prusa et al.
Colorectal cancer (CRC) remains a major burden of cancer-related morbidity and mortality globally, especially when detected at later stages. Early detection through improved and more accessible diagnostics is critical for reducing the sever...
APOE4 genotype shapes the role of dietary fibers in cognitive health through gut microbiota changes [0.03%]
饮食纤维通过改变肠道菌群对ApoE4基因型在认知健康中的作用的影响
Marrium Liaquat,Gwenaelle Le Gall,Andrew Scholey et al.
Marrium Liaquat et al.
APOE4, a key risk factor for Alzheimer's disease, influences gut microbiota and microbial metabolites (e.g. amino acids and dietary fiber (DF) derived short-chain fatty acids (SCFAs)). However, its role in modulating microbiota-driven DF me...
The accessory type III secretion system effectors collectively shape intestinal inflammatory infection outcomes [0.03%]
III型分泌系统效应物集体塑造肠道炎症感染结果
Priyanka Biswas,Julia Sanchez-Garrido,Zuzanna Kozik et al.
Priyanka Biswas et al.
Injection of effectors via a type III secretion system (T3SS) is an infection strategy shared by various Gram-negative bacterial pathogens, many infecting mucosal surfaces. While individual T3SS effectors are well characterized, their netwo...
Gut microbial Nordihydroguaiaretic acid suppresses macrophage pyroptosis to regulate epithelial homeostasis and inflammation [0.03%]
肠道微生物代谢产物抑制巨噬细胞焦亡从而调节上皮稳态和炎症反应
Jun Wang,Huishi Tan,Ziwen Ye et al.
Jun Wang et al.
Background: Aging is associated with increased severity of inflammatory bowel disease (IBD). Gut senescence and altered environmental factors contribute to changes in the intestinal metabolome, particularly in frail older...
Yang Tang,Anbo Fu,Liangjing Wang et al.
Yang Tang et al.
Microbiota-dependent metabolites (MDMs) are small bioactive molecules produced or modified through microbial metabolic processes, playing an essential role in the communication between prokaryotic and eukaryotic cells. One of their most imp...
Intestinal host-microbe interactions fuel pulmonary inflammation in cigarette smoke exposed mice [0.03%]
暴露于香烟烟雾中的小鼠肠道宿主微生物相互作用引发肺部炎症
Sune K Yang-Jensen,Nora Näegele,Si Brask Sonne et al.
Sune K Yang-Jensen et al.
The gut microbiota has been implicated in numerous aspects of host health and immune regulation. Specifically, recent studies have linked gut microbes to the pathogenesis of chronic obstructive pulmonary disease (COPD), primarily induced by...
Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment [0.03%]
肠道微生物组和肿瘤微环境中昼夜节律驱动的失调动态变化
Taoxing Peng,Yiqi Wan,Yuxuan Sun et al.
Taoxing Peng et al.
Circadian rhythms govern physiological activities through the precise modulation of gene expression and biochemical functions. Dysfunction of circadian rhythms is associated with an increased risk of tumor formation, growth, and metastasis,...
Gut microbial metabolite butyrate suppresses hepatocellular carcinoma growth via CXCL11-dependent enhancement of natural killer cell infiltration [0.03%]
肠道微生物代谢产物丁酸通过CXCL11依赖性增强自然杀伤细胞浸润来抑制肝癌生长
Menghan Zhang,Xuefeng Huang,Yanlong Zhang et al.
Menghan Zhang et al.
Gut microbiota-derived butyrate plays a vital role in attenuating hepatocellular carcinoma (HCC) in murine models. However, the precise molecular mechanisms by which butyrate exerts its effects are largely undefined. Plasma short-chain fatt...
Lactulose selectively stimulates members of the gut microbiota, as determined by multi-modal activity-based sorting [0.03%]
乳果糖选择性地刺激肠道微生物群中的成员，多模式活性基排序测定结果表明如此
Hamid Rasoulimehrabani,Alessandra Riva,Deniz Inan et al.
Hamid Rasoulimehrabani et al.
There is much interest in the development of dietary supplements that selectively promote the growth of beneficial gut bacteria. The selectivity of many candidate prebiotics has, however, not been thoroughly investigated. Here, we evaluated...