Gut microbial features and dietary fiber intake predict gut microbiota response to resistant starch supplementation [0.03%]
肠道微生物特点和膳食纤维摄入量可预测抗性淀粉补充对肠道菌群的影响
Sri Lakshmi Sravani Devarakonda,Dorothy K Superdock,Jennifer Ren et al.
Sri Lakshmi Sravani Devarakonda et al.
Resistant starch (RS) consumption can have beneficial effects on metabolic health, but the response, in terms of effects on the gut microbiota and host physiology, varies between individuals. Factors predicting the response to RS are not ye...
Modulation of Alzheimer's disease brain pathology in mice by gut bacterial depletion: the role of IL-17a [0.03%]
肠道细菌损耗对小鼠阿尔茨海默病脑病理的影响及IL-17a的作用
Wenlin Hao,Qinghua Luo,Inge Tomic et al.
Wenlin Hao et al.
Gut bacteria regulate brain pathology of Alzheimer's disease (AD) patients and animal models; however, the underlying mechanism remains unclear. In this study, 3-month-old APP-transgenic female mice with and without knock-out of Il-17a gene...
Tanja Dapa,Karina B Xavier
Tanja Dapa
The gut microbiota, comprising trillions of diverse microorganisms inhabiting the intestines of animals, forms a complex and indispensable ecosystem with profound implications for the host's well-being. Its functions include contributing to...
Hui Zhan,Yating Wan,Yang Sun et al.
Hui Zhan et al.
The gut fungi play important roles in human health and are involved in energy metabolism. This study aimed to examine gut mycobiome composition in obese subjects in two geographically different regions in China and to identify specific gut ...
Heterologous expression and antimicrobial potential of class II bacteriocins [0.03%]
异源表达及各类II型细菌素的抗菌潜力研究
Carola Elisa Heesemann Rosenkilde,Ditte Olsen Lützhøft,Ruben Vazquez-Uribe et al.
Carola Elisa Heesemann Rosenkilde et al.
Gut bacteria are known to produce bacteriocins to inhibit the growth of other bacteria. Consequently, bacteriocins have attracted increased attention as potential microbiome-editing tools. In this study we examine the inhibitory spectrum of...
MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis [0.03%]
MUP1通过肠-微生物群-肝轴介导石榴素A改善慢性酒精性肝病
Hongbo Zhang,Chaoyue Li,Lin Han et al.
Hongbo Zhang et al.
Alcohol-related liver disease (ALD) is recognized as a global health crisis, contributing to approximately 20% of liver cancer-associated fatalities. Dysbiosis of the gut microbiome is associated with the development of ALD, with the gut mi...
Gut microbiome encoded purine and amino acid pathways present prospective biomarkers for predicting metformin therapy efficacy in newly diagnosed T2D patients [0.03%]
肠道微生物组编码的嘌呤和氨基酸途径可作为预测新诊断T2D患者二甲双胍治疗疗效的生物标志物
Ilze Elbere,Zigmunds Orlovskis,Laura Ansone et al.
Ilze Elbere et al.
Metformin is widely used for treating type 2 diabetes mellitus (T2D). However, the efficacy of metformin monotherapy is highly variable within the human population. Understanding the potential indirect or synergistic effects of metformin on...
Adaptation to tolerate high doses of arabinoxylan is associated with fecal levels of Bifidobacterium longum [0.03%]
适应高剂量阿拉伯木聚糖的耐受与长双歧杆菌粪便水平相关性分析
Edward C Deehan,Zhengxiao Zhang,Nguyen K Nguyen et al.
Edward C Deehan et al.
Dietary fiber supplements are a strategy to close the 'fiber gap' and induce targeted modulations of the gut microbiota. However, higher doses of fiber supplements cause gastrointestinal (GI) symptoms that differ among individuals. What det...
Randomized Controlled Trial
Gut microbes. 2024 Jan-Dec;16(1):2363021. DOI:10.1080/19490976.2024.2363021 2024
Probiotics and microbial metabolites maintain barrier and neuromuscular functions and clean protein aggregation to delay disease progression in TDP43 mutation mice [0.03%]
益生菌及其代谢产物可维持屏障和神经肌肉功能并清除蛋白质聚集以延缓TDP43突变小鼠疾病进展
Yongguo Zhang,Yinglin Xia,Jun Sun
Yongguo Zhang
Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. The ALS mice expressing human mutant of transactive response DNA binding protein of 43 kDa (hmTDP43) showed intestinal dysfunction before neuromuscular symptoms. We hypothesize...
Association between gut microbiota and CpG island methylator phenotype in colorectal cancer [0.03%]
肠道菌群与结直肠癌CpG岛甲基化表型的关系研究
Pyoung Hwa Park,Kelsey Keith,Gennaro Calendo et al.
Pyoung Hwa Park et al.
The intestinal microbiota is an important environmental factor implicated in CRC development. Intriguingly, modulation of DNA methylation by gut microbiota has been reported in preclinical models, although the relationship between tumor-inf...