Quinic acid alleviates high-fat diet-induced neuroinflammation by inhibiting DR3/IKK/NF-κB signaling via gut microbial tryptophan metabolites [0.03%]
quinic酸通过肠道微生物色氨酸代谢物抑制DR3/IKK/NF-кB信号缓解高脂饮食诱导的神经炎症
Sen Li,Yuwei Cai,Tong Guan et al.
Sen Li et al.
With the increasing of aging population and the consumption of high-fat diets (HFD), the incidence of Alzheimer's disease (AD) has skyrocketed. Natural antioxidants show promising potential in the prevention of AD, as oxidative stress and n...
The transcriptional regulation of the horizontally acquired iron uptake system, yersiniabactin and its contribution to oxidative stress tolerance and pathogenicity of globally emerging salmonella strains [0.03%]
沙门氏菌获得性铁吸收系统耶尔син亚bac素的转录调控及其对全球新兴沙门氏菌毒力和耐氧化应激的贡献
Imbar Diamant,Boaz Adani,Meir Sylman et al.
Imbar Diamant et al.
The bacterial species Salmonella enterica (S. enterica) is a highly diverse pathogen containing more than 2600 distinct serovars, which can infect a wide range of animal and human hosts. Recent global emergence of multidrug resistant strain...
Oral histidine affects gut microbiota and MAIT cells improving glycemic control in type 2 diabetes patients [0.03%]
口服组氨酸影响肠道微生物群和MAIT细胞改善2型糖尿病患者的血糖控制
Moritz V Warmbrunn,Ilias Attaye,Judith Aron-Wisnewsky et al.
Moritz V Warmbrunn et al.
Amino acids, metabolized by host cells as well as commensal gut bacteria, have signaling effects on host metabolism. Oral supplementation of the essential amino acid histidine has been shown to exert metabolic benefits. To investigate wheth...
Disruption of intestinal oxygen balance in acute colitis alters the gut microbiome [0.03%]
肠道急性结肠炎扰乱肠道氧平衡改变肠道微生物群
Wenjing Zong,Elliot S Friedman,Srinivasa Rao Allu et al.
Wenjing Zong et al.
The juxtaposition of well-oxygenated intestinal colonic tissue with an anerobic luminal environment supports a fundamentally important relationship that is altered in the setting of intestinal injury, a process likely to be relevant to dise...
Narjis Kraimi,Taylor Ross,Julien Pujo et al.
Narjis Kraimi et al.
Functional gastrointestinal disorders (FGIDs), chronic disorders characterized by either abdominal pain, altered intestinal motility, or their combination, have a worldwide prevalence of more than 40% and impose a high socioeconomic burden ...
Intratumoral microbiome is associated with gastric cancer prognosis and therapy efficacy [0.03%]
肿瘤内微生物组与胃癌预后及治疗疗效相关
Gangjian Wang,Haojie Wang,Xin Ji et al.
Gangjian Wang et al.
The role of the intratumoral microbiome in gastric cancer (GC) has not been comprehensively assessed. Here, we explored the relationship between the microbial community and GC prognosis and therapy efficacy. Several cancer-associated microb...
Gut microbiota-mediated polyphenol metabolism is restrained by parasitic whipworm infection and associated with altered immune function in mice [0.03%]
寄生线虫感染通过调控肠道菌群介导的多酚代谢影响小鼠免疫功能
Audrey Inge Schytz Andersen-Civil,Pankaj Arora,Ling Zhu et al.
Audrey Inge Schytz Andersen-Civil et al.
Polyphenols are phytochemicals commonly found in plant-based diets which have demonstrated immunomodulatory and anti-inflammatory properties. However, the interplay between polyphenols and pathogens at mucosal barrier surfaces has not yet b...
Washed microbiota transplantation promotes homing of group 3 innate lymphoid cells to the liver via the CXCL16/CXCR6 axis: a potential treatment for metabolic-associated fatty liver disease [0.03%]
洗涤菌群移植通过CXCL16/CXCR6轴促进第3组固有淋巴样细胞向肝脏归巢：代谢相关脂肪性肝病的潜在治疗方法
Hao-Jie Zhong,Yu-Pei Zhuang,Xinqiang Xie et al.
Hao-Jie Zhong et al.
Despite the observed decrease in liver fat associated with metabolic-associated fatty liver disease (MAFLD) in mice following fecal microbiota transplantation, the clinical effects and underlying mechanisms of washed microbiota transplantat...
The microbiota and the host organism switch between cooperation and competition based on dietary iron levels [0.03%]
宿主与微生物群之间的互动受膳食中铁含量的影响可相互竞争亦可互利协作
Marie-Louise Noordine,Yohannes Seyoum,Aurélia Bruneau et al.
Marie-Louise Noordine et al.
The microbiota significantly impacts digestive epithelium functionality, especially in nutrient processing. Given the importance of iron for both the host and the microbiota, we hypothesized that host-microbiota interactions fluctuate with ...
Restricted intake of sulfur-containing amino acids reversed the hepatic injury induced by excess Desulfovibrio through gut-liver axis [0.03%]
限制含硫氨基酸的摄入可逆转肠道衍生硫酸盐还原菌诱导的肝脏损伤
Lingxi Zhou,Gexue Lu,Yawen Nie et al.
Lingxi Zhou et al.
Diet is a key player in gut-liver axis. However, the effect of different dietary patterns on gut microbiota and liver functions remains unclear. Here, we used rodent standard chow and purified diet to mimic two common human dietary patterns...