A history of repeated antibiotic usage leads to microbiota-dependent mucus defects [0.03%]
反复使用抗生素导致依赖于微生物群的黏膜缺陷的历史
Kertu Liis Krigul,Rachel H Feeney,Supapit Wongkuna et al.
Kertu Liis Krigul et al.
Recent evidence indicates that repeated antibiotic usage lowers microbial diversity and ultimately changes the gut microbiota community. However, the physiological effects of repeated - but not recent - antibiotic usage on microbiota-mediat...
Correction [0.03%]
改正措施
Published Erratum
Gut microbes. 2024 Jan-Dec;16(1):2377878. DOI:10.1080/19490976.2024.2377878 2024
Juliana de Castilhos,Katharina Tillmanns,Jana Blessing et al.
Juliana de Castilhos et al.
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer characterized by late diagnosis, rapid progression, and a high mortality rate. Its complex biology, characterized by a dense, stromal tumor environment with an immunosupp...
CRIg+ macrophages deficiency enhanced inflammation damage in IBD due to gut extracellular vesicles containing microbial DNA [0.03%]
肠道含微生物DNA的细胞外囊泡通过CRIg+巨噬细胞缺陷加重IBD炎症损伤
Shangshu Nie,Zhongchao Zhang,Yudong Ji et al.
Shangshu Nie et al.
Gut microbiota-derived extracellular vesicles (mEVs) are reported to regulate inflammatory response by delivering bacterial products into host cells. The complement receptor of the immunoglobulin superfamily macrophages (CRIg+ Mφ) could cl...
Bacteroides fragilis alleviates necrotizing enterocolitis through restoring bile acid metabolism balance using bile salt hydrolase and inhibiting FXR-NLRP3 signaling pathway [0.03%]
脆弱拟杆菌通过水解肠道胆汁酸恢复胆盐平衡并抑制FXR-NLRP3信号通路从而改善坏死性小肠结肠炎
Zhenhui Chen,Huijuan Chen,Wanwen Huang et al.
Zhenhui Chen et al.
Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in premature infants with no specific treatments available. We aimed to identify the molecular mechanisms underlying NEC and investigate the therapeutic effects o...
Gut microbiota promotes macrophage M1 polarization in hepatic sinusoidal obstruction syndrome via regulating intestinal barrier function mediated by butyrate [0.03%]
肠道微生物群通过调控丁酸介导的肠屏障功能促进肝血窦阻塞综合征中巨噬细胞M1极化
Si Zhao,Han Zhang,Hanlong Zhu et al.
Si Zhao et al.
Background: The intestinal-liver axis is associated with various liver diseases. Here, we verified the role of the gut microbiota and macrophage activation in the progression of pyrrolizidine alkaloids-induced hepatic sin...
Implications of microbe-derived ɣ-aminobutyric acid (GABA) in gut and brain barrier integrity and GABAergic signaling in Alzheimer's disease [0.03%]
微生菌衍生的γ-氨基丁酸(伽马氨基丁酸)对肠道和大脑屏障完整性和阿尔茨海默病中伽马氨基丁酸能信号传导的影响
Kathryn A Conn,Emily M Borsom,Emily K Cope
Kathryn A Conn
The gut microbial ecosystem communicates bidirectionally with the brain in what is known as the gut-microbiome-brain axis. Bidirectional signaling occurs through several pathways including signaling via the vagus nerve, circulation of micro...
Diana Meireles,Rita Pombinho,Didier Cabanes
Diana Meireles
The tight and coordinated regulation of virulence gene expression is crucial to ensure the survival and persistence of bacterial pathogens in different contexts within their hosts. Considering this, bacteria do not express virulence factors...
Comprehensive assessment of machine learning methods for diagnosing gastrointestinal diseases through whole metagenome sequencing data [0.03%]
基于全元基因组测序数据诊断胃肠道疾病机器学习方法的全面评估
Sungho Lee,Insuk Lee
Sungho Lee
The gut microbiome, linked significantly to host diseases, offers potential for disease diagnosis through machine learning (ML) pipelines. These pipelines, crucial in modeling diseases using high-dimensional microbiome data, involve selecti...
A powerful machine learning approach to identify interactions of differentially abundant gut microbial subsets in patients with metastatic and non-metastatic pancreatic cancer [0.03%]
一种强大的机器学习方法，用于识别转移性胰腺癌和非转移性胰腺癌患者肠道中不同丰富度的微生物亚群之间的相互作用
Annacandida Villani,Andrea Fontana,Concetta Panebianco et al.
Annacandida Villani et al.
Pancreatic cancer has a dismal prognosis, as it is often diagnosed at stage IV of the disease and is characterized by metastatic spread. Gut microbiota and its metabolites have been suggested to influence the metastatic spread by modulating...