Serum bile acids profiles are altered without change of the gut microbiota composition following a seven-day prednisolone therapy in severe alcoholic hepatitis [0.03%]
强的松治疗严重酒精性肝炎7天未改变肠道菌群但改变了血清胆汁酸谱型
Damien Esparteiro,Grégory Fouquet,Anoïsia Courtois et al.
Damien Esparteiro et al.
Severe Alcoholic Hepatitis (sAH) is an acute form of liver injury caused by chronic and heavy alcohol drinking. A one-month corticosteroids course is the only sAH reference treatment, and its interactions with the Gut Microbiota (GM), which...
AIEC-dependent pathogenic Th17 cell transdifferentiation in Crohn's disease is suppressed by rfaP and ybaT deletion [0.03%]
Crohn病中依赖于AIEC的致病性Th17细胞转分化由rfaP和ybaT基因敲除抑制
G Leccese,M Chiara,I Dusetti et al.
G Leccese et al.
Mucosal enrichment of the Adherent-Invasive E. coli (AIEC) pathotype and the expansion of pathogenic IFNγ-producing Th17 (pTh17) cells have been linked to Crohn's Disease (CD) pathogenesis. However, the molecular pathways underlying the AI...
Enhancing recovery from gut microbiome dysbiosis and alleviating DSS-induced colitis in mice with a consortium of rare short-chain fatty acid-producing bacteria [0.03%]
利用一组罕见短链脂肪酸产生菌改善小鼠肠道微生物群失调及葡聚糖硫酸钠诱导的结肠炎康复
Achuthan Ambat,Linto Antony,Abhijit Maji et al.
Achuthan Ambat et al.
The human gut microbiota is a complex community comprising hundreds of species, with a few present in high abundance and the vast majority in low abundance. The biological functions and effects of these low-abundant species on their hosts a...
AUF1-mediated inhibition of autophagic lysosomal degradation contributes to CagA stability and Helicobacter pylori-induced inflammation [0.03%]
AUF1介导的自噬溶酶体降解抑制作用促进了CagA稳定性和幽门螺旋杆菌诱导的炎症反应
Huiling Zheng,Ting Zhang,Jing Zhang et al.
Huiling Zheng et al.
CagA, a virulence factor of Helicobacter pylori (H. pylori), is known to drive inflammation in gastric epithelial cells and is typically degraded through autophagy. However, the molecular mechanism by which CagA evades autophagy-mediated de...
Bacteriophages from treatment-naïve type 2 diabetes individuals drive an inflammatory response in human co-cultures of dendritic cells and T cells [0.03%]
来自未接受治疗的2型糖尿病个体的噬菌体在人树突细胞和T细胞共培养中驱动炎症反应
Torsten P M Scheithauer,Koen Wortelboer,Maaike Winkelmeijer et al.
Torsten P M Scheithauer et al.
Individuals with type 2 diabetes (T2D) show signs of low-grade inflammation, which is related to the development of insulin resistance and beta-cell dysfunction. However, the underlying triggers remain unknown. The gut microbiota is a plaus...
Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial homeostasis through mucin sulfation [0.03%]
肠道微生物代谢物吲哚-3-乙酸通过黏蛋白硫酸化维持肠上皮稳态
Mengfan Li,Yiyun Ding,Jingge Wei et al.
Mengfan Li et al.
The global incidence and prevalence of inflammatory bowel disease (IBD) are gradually increasing. A high-fat diet (HFD) is known to disrupt intestinal homeostasis and aggravate IBD, yet the underlying mechanisms remain largely undefined. He...
The crosstalk between efflux pump and resistance gene mutation in Helicobacter pylori [0.03%]
幽门螺杆菌外排泵与耐药基因突变的互作关系
Xiaoling Gong,Youhua Wang,Ying An et al.
Xiaoling Gong et al.
Efflux pumps play a crucial role in the development of antibiotic resistance. The aim of this study was to investigate the relationship between efflux pump gene expression and resistance gene mutations in Helicobacter pylori. Twenty-six cli...
Gut microbiota-derived fatty acid and sterol metabolites: biotransformation and immunomodulatory functions [0.03%]
肠道微生物衍生的脂肪酸和固醇代谢物：生物转化与免疫调节功能
Haohao Zhang,Yadong Xie,Fei Cao et al.
Haohao Zhang et al.
Commensal microorganisms in the human gut produce numerous metabolites by using small molecules derived from the host or diet as precursors. Host or dietary lipid molecules are involved in energy metabolism and maintaining the structural in...
Mechanisms of intestinal dysbiosis: new insights into tuft cell functions [0.03%]
肠上皮异位与肠道菌群失调：毛细胞功能的新见解
Nathalie Coutry,Imène Gasmi,Fabien Herbert et al.
Nathalie Coutry et al.
Symbiosis between the host and intestinal microbial communities is essential for human health. Disruption in this symbiosis is linked to gastrointestinal diseases, including inflammatory bowel diseases, as well as extra-gastrointestinal dis...
Neonatal intestinal colonization of Streptococcus agalactiae and the multiple modes of protection limiting translocation [0.03%]
新生儿肠球链锁菌定植及多种保护机制限制其穿过肠道屏障的作用
Kara G Greenfield,Olivia S Harlow,Lila T Witt et al.
Kara G Greenfield et al.
Streptococcus agalactiae, also known as Group B Streptococcus (GBS), is a predominant pathogen of neonatal sepsis, commonly associated with early-onset neonatal sepsis. GBS has also been associated with cases of late-onset sepsis potentiall...