Gene content, phage cycle regulation model and prophage inactivation disclosed by prophage genomics in the Helicobacter pylori Genome Project [0.03%]
胃螺杆菌基因组计划中的噬菌体基因组揭示了基因含量、噬菌体周期调节模型和前噬菌体失活
Filipa F Vale,Richard J Roberts,Ichizo Kobayashi et al.
Filipa F Vale et al.
Prophages can have major clinical implications through their ability to change pathogenic bacterial traits. There is limited understanding of the prophage role in ecological, evolutionary, adaptive processes and pathogenicity of Helicobacte...
Symbiotic biofilms formed by Clostridioides difficile and bacteroides thetaiotaomicron in the presence of vancomycin [0.03%]
万古霉素存在下脆弱类杆菌与艰难梭菌互养型生物被膜的形成
Jingpeng Yang,Wen Rui,Saiwei Zhong et al.
Jingpeng Yang et al.
Vancomycin (VAN) treatment in Clostridioides difficile infection (CDI) suffers from a relatively high rate of recurrence, with a variety of reasons behind this, including biofilm-induced recurrent infections. C. difficile can form monophyle...
The early life exposome and autism risk: a role for the maternal microbiome? [0.03%]
生命组暴露与自闭症风险：母体微生物群的作用？
Claudia M Di Gesù,Shelly A Buffington
Claudia M Di Gesù
Autism spectrum disorders (ASD) are highly heritable, heterogeneous neurodevelopmental disorders characterized by clinical presentation of atypical social, communicative, and repetitive behaviors. Over the past 25 years, hundreds of ASD ris...
Game of microbes: the battle within - gut microbiota and multiple sclerosis [0.03%]
肠道微生物的博弈与多发性硬化症的关系
Ti-Ara Turner,Peter Lehman,Sudeep Ghimire et al.
Ti-Ara Turner et al.
Multiple sclerosis (MS) is a chronic and progressive autoimmune disease of the central nervous system (CNS), with both genetic and environmental factors contributing to the pathobiology of the disease. While human leukocyte antigen (HLA) ge...
Pseudocin 196, a novel lantibiotic produced by Bifidobacterium pseudocatenulatum elicits antimicrobial activity against clinically relevant pathogens [0.03%]
Bifidobacterium pseudocatenulatum产生的一种新的环状肽类抗菌素Pseudocin 196对临床相关病原菌具有抗菌活性
Rocio Sanchez-Gallardo,Paula M O&#x;Connor,Ian J O&#x;Neill et al.
Rocio Sanchez-Gallardo et al.
Bacteriocins are broad or narrow-spectrum antimicrobial compounds that have received significant scientific attention due to their potential to treat infections caused by antibiotic-resistant pathogenic bacteria. The genome of Bifidobacteri...
Phage lysins for intestinal microbiome modulation: current challenges and enabling techniques [0.03%]
噬菌体溶菌酶在肠道微生物组调节中的应用：当前挑战与实现技术
Iris Pottie,Roberto Vázquez Fernández,Tom Van de Wiele et al.
Iris Pottie et al.
The importance of the microbiota in the intestinal tract for human health has been increasingly recognized. In this perspective, microbiome modulation, a targeted alteration of the microbial composition, has gained interest. Phage lysins, p...
The fecal microbiota of patients with primary biliary cholangitis (PBC) causes PBC-like liver lesions in mice and exacerbates liver damage in a mouse model of PBC [0.03%]
原发性胆汁性胆管炎（PBC）患者肠道菌群导致小鼠出现类似PBC的肝脏病变并加重PBC模型小鼠肝损伤
Huiyong Jiang,Ying Yu,Xiaoxiang Hu et al.
Huiyong Jiang et al.
The role of the gut microbiota in the occurrence and progression of primary biliary cholangitis (PBC) is not fully understood. First, the fecal microbiota of patients with PBC (n = 4) (PBC-FMT) or healthy individuals (n = 3) (HC-FMT) was tr...
A cohort study in family triads: impact of gut microbiota composition and early life exposures on intestinal resistome during the first two years of life [0.03%]
一项家系三人组的队列研究：肠道微生物群组成和生命早期暴露对生命头两年肠道耐药基因库的影响
Roosa Jokela,Katariina Mm Pärnänen,Alise J Ponsero et al.
Roosa Jokela et al.
Antibiotic resistance genes (ARGs) are prevalent in the infant gut microbiota and make up the intestinal resistome, representing a community ARG reservoir. This study focuses on the dynamics and persistence of ARGs in the early gut microbio...
Current insights on gut microbiome and chronic urticaria: progress in the pathogenesis and opportunities for novel therapeutic approaches [0.03%]
肠道微生物群和慢性荨麻疹的最新研究进展：发病机制的新见解及新型治疗策略的机会
Rui Cai,Changhan Zhou,Ruisi Tang et al.
Rui Cai et al.
Chronic urticaria (CU) is a prevalent skin disorder greatly impacting the patients' life quality, in which immune dysregulation mediated by gut microbiome plays a significant role. Several studies have found the gut dysbiosis exists in pati...
MS-20 enhances the gut microbiota-associated antitumor effects of anti-PD1 antibody [0.03%]
MS-20增强抗PD-1抗体的肠道微生态系统抗肿瘤效果
Pei-Jung Lee,Chien-Min Hung,Ai-Jen Yang et al.
Pei-Jung Lee et al.
Cancer immunotherapy has been regarded as a promising strategy for cancer therapy by blocking immune checkpoints and evoking immunity to fight cancer, but its efficacy seems to be heterogeneous among patients. Manipulating the gut microbiot...