Chronic binge drinking-induced susceptibility to colonic inflammation is microbiome-dependent [0.03%]
慢性醉酒引起的结肠炎易感性与菌群相关
Diogo Fonseca-Pereira,Sena Bae,Monia Michaud et al.
Diogo Fonseca-Pereira et al.
Alterations in intestinal permeability and the gut microbiome caused by alcohol abuse are associated with alcoholic liver disease and with worsening of inflammatory bowel diseases (IBD) symptoms. To resolve the direct effects of chronic eth...
Quercetin activates energy expenditure to combat metabolic syndrome through modulating gut microbiota-bile acids crosstalk in mice [0.03%]
芦丁通过调节肠道菌群-胆汁酸互作激活能量消耗从而对抗代谢综合征（小鼠模型）
Xiaoqiang Zhu,Xiaojuan Dai,Lijun Zhao et al.
Xiaoqiang Zhu et al.
Abdominal obesity-related metabolic syndrome (MetS) has emerged as a significant global public health issue that affects human health. Flavonoids, such as quercetin, have been reported to exert obvious anti-obesity and lipid-lowering effect...
Microbiota and plasticity of antigen-presenting ILC3s: impact on antitumor immune response [0.03%]
抗原呈递ILC3的微生物群和可塑性及其对抗肿瘤免疫反应的影响
Alessia Calabrò,Fabiana Drommi,Claudia De Pasquale et al.
Alessia Calabrò et al.
Growing evidence highlights the pivotal role of RORγt-innate lymphoid cells (ILCs) in the establishment of antitumor immune response and in enhancing tumor sensitivity to immunotherapy. Noteworthy, type 3 ILCs (ILC3s) have been recently ac...
Microbiota during pregnancy and early life: role in maternal-neonatal outcomes based on human evidence [0.03%]
孕期及生命早期的微生物组及其对母体-新生儿结局的影响：基于人类研究的证据分析
Alessio Fasano,Benoit Chassaing,Dirk Haller et al.
Alessio Fasano et al.
Here, we explored the vast potential of microbiome-based interventions in preventing and managing non-communicable diseases including obesity, diabetes, allergies, celiac disease, inflammatory bowel diseases, malnutrition, and cardiovascula...
Time-restricted feeding ameliorates non-alcoholic fatty liver disease through modulating hepatic nicotinamide metabolism via gut microbiota remodeling [0.03%]
限时饮食通过重塑肠道菌群调节肝脏烟酰胺代谢从而改善非酒精性脂肪肝病
Ruijia Feng,Wenchao Yang,Weiqi Feng et al.
Ruijia Feng et al.
Non-alcoholic fatty liver disease (NAFLD) has emerged as a global health concern, lacking specific therapeutic strategies. Time-restricted feeding (TRF) regimen demonstrated beneficial effects in NAFLD; however, the underlying mechanisms re...
Deciphering internal and external factors influencing intestinal junctional complexes [0.03%]
揭示影响肠细胞连接的内外因素
Zachary Markovich,Adriana Abreu,Yi Sheng et al.
Zachary Markovich et al.
The intestinal barrier, an indispensable guardian of gastrointestinal health, mediates the intricate exchange between internal and external environments. Anchored by evolutionarily conserved junctional complexes, this barrier meticulously r...
Microbial metabolism marvels: a comprehensive review of microbial drug transformation capabilities [0.03%]
微生物代谢奇迹：微生物药物转化能力的全面回顾
Filippo Martinelli,Ines Thiele
Filippo Martinelli
This comprehensive review elucidates the pivotal role of microbes in drug metabolism, synthesizing insights from an exhaustive analysis of over two hundred papers. Employing a structural classification system grounded in drug atom involveme...
Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa [0.03%]
囊性纤维化小鼠结肠黏膜中致病大肠杆菌介导的DNA加合物形成增加
Amanda Mandarino Alves,Chiara Lecchi,Sharon Lopez et al.
Amanda Mandarino Alves et al.
Colibactin is a recently characterized pro-carcinogenic genotoxin produced by pks+ Escherichia coli. We hypothesized that cystic fibrosis (CF)-associated dysfunctional mucus structure increases the vulnerability of host mucosa to colibactin...
Comparison of gnotobiotic communities reveals milk-adapted metabolic functions and unexpected amino acid metabolism by the pre-weaning microbiome [0.03%]
比较无菌动物共生群落发现牛奶适应性代谢功能以及断奶前微生物组的意外氨基酸代谢能力
Jean-Bernard Lubin,Michael A Silverman,Paul J Planet
Jean-Bernard Lubin
The intestinal microbiome during infancy and childhood has distinct metabolic functions and microbial composition compared to adults. We recently published a gnotobiotic mouse model of the pre-weaning microbiome (PedsCom), which retains a p...
Comparative Study
Gut microbes. 2024 Jan-Dec;16(1):2387875. DOI:10.1080/19490976.2024.2387875 2024
Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion [0.03%]
牙龈卟啉单胞菌通过CHI3L1介导的iNKT细胞驱动免疫逃逸促进结直肠癌发展
Angélica Díaz-Basabe,Georgia Lattanzi,Federica Perillo et al.
Angélica Díaz-Basabe et al.
The interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences the anti-tumor functions of CRC-infiltrating iNKT cell...