Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion [0.03%]
乳酸菌通过抑制胆汁酸合成和促进胆汁酸排泄来改善胆汁淤积性肝损伤
Lingyi Wu,Jianchun Zhou,An Zhou et al.
Lingyi Wu et al.
Gut microbiota dysbiosis is involved in cholestatic liver diseases. However, the mechanisms remain to be elucidated. The purpose of this study was to examine the effects and mechanisms of Lactobacillus acidophilus (L. acidophilus) on choles...
Randomized Controlled Trial
Gut microbes. 2024 Jan-Dec;16(1):2390176. DOI:10.1080/19490976.2024.2390176 2024
Shu Chen,Zhao Zhang,Sanxin Liu et al.
Shu Chen et al.
Gut microbiota of centenarians has garnered significant attention in recent years, with most studies concentrating on the analysis of microbial composition. However, there is still limited knowledge regarding the consistent signatures of sp...
Synergism of Fusobacterium periodonticum and N-nitrosamines promote the formation of EMT subtypes in ESCC by modulating Wnt3a palmitoylation [0.03%]
牙龈密螺旋体和N-亚硝胺通过调节Wnt3a棕榈酰化促进食管鳞癌中EMT亚型的形成
Mingjun Sun,Zhenyan Peng,Weitao Shen et al.
Mingjun Sun et al.
N-Nitrosamine disinfection by-products (NAs-DBPs) have been well proven for its role in esophageal carcinogenesis. However, the role of intratumoral microorganisms in esophageal squamous cell carcinoma (ESCC) has not yet been well explored ...
Bacterial amyloid curli activates the host unfolded protein response via IRE1α in the presence of HLA-B27 [0.03%]
细菌淀粉样蛋白curli通过IRE1α激活HLA-B27存在的宿主未折叠蛋白质反应
Kaitlyn Grando,Shingo Bessho,Kayla Harrell et al.
Kaitlyn Grando et al.
Salmonella enterica serovar Typhimurium (STm) causes gastroenteritis and can progress to reactive arthritis (ReA). STm forms biofilms in the gut that secrete the amyloid curli, which we previously demonstrated can trigger autoimmunity in mi...
Prevention and cure of murine C. difficile infection by a Lachnospiraceae strain [0.03%]
一枚乳酸菌株预防和治疗小鼠艰难梭菌感染
Juan Noriega Tejada,William A Walters,Yanling Wang et al.
Juan Noriega Tejada et al.
We sought to better understand how intestinal microbiota confer protection against Clostridioides difficile (C. difficile) infection (CDI). We utilized gnotobiotic altered Schaedler flora (ASF) mice, which lack the abnormalities of germfree...
Effects of postbiotics on chronic diarrhea in young adults: a randomized, double-blind, placebo-controlled crossover trial assessing clinical symptoms, gut microbiota, and metabolite profiles [0.03%]
后生元对成人慢性腹泻的疗效：一项关于临床症状、肠道微生物组和代谢产物谱的随机双盲安慰剂对照交叉试验
Shuai Guo,Teng Ma,Lai-Yu Kwok et al.
Shuai Guo et al.
Chronic diarrhea has a considerable impact on quality of life. This randomized, double-blind, placebo-controlled crossover intervention trial was conducted with 69 participants (36 in Group A, 33 in Group B), aiming to investigate the poten...
Randomized Controlled Trial
Gut microbes. 2024 Jan-Dec;16(1):2395092. DOI:10.1080/19490976.2024.2395092 2024
Gut microbiome profiles to exclude the diagnosis of hepatic encephalopathy in patients with cirrhosis [0.03%]
肠道微生物组特征可排除肝硬化的肝性脑病诊断
Jasmohan S Bajaj,Jacqueline G O&#x;Leary,Sofia S Jakab et al.
Jasmohan S Bajaj et al.
Patients with cirrhosis who have cognitive complaints are presumed to have hepatic encephalopathy (HE), which leads to unwarranted medications while ignoring the underlying disease process causing these complaints. Since neuropsychological ...
Multicenter Study
Gut microbes. 2024 Jan-Dec;16(1):2392880. DOI:10.1080/19490976.2024.2392880 2024
Gut virome and microbiome dynamics before and after SARS-CoV-2 infection in women living with HIV and their infants [0.03%]
HIV阳性妇女及其婴儿在感染SARS-CoV-2前后的肠道病毒组和微生物组动态变化
Rabia Maqsood,LaRinda A Holland,Lily I Wu et al.
Rabia Maqsood et al.
Microbiome perturbations can have long-term effects on health. The dynamics of the gut microbiome and virome in women living with HIV (WLHIV) and their newborn infants is poorly understood. Here, we performed metagenomic sequencing analyses...
Microbiota and glioma: a new perspective from association to clinical translation [0.03%]
微生物菌群与胶质瘤：从相关性到临床转化的新视野
Wenhui Wang,Zihao Ou,Xixin Huang et al.
Wenhui Wang et al.
Gliomas pose a significant challenge in oncology due to their malignant nature, aggressive growth, frequent recurrence, and complications posed by the blood-brain barrier. Emerging research has revealed the critical role of gut microbiota i...
Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity [0.03%]
为期12周的联合多酚补充对超重或肥胖人群肠道菌群与宿主代谢性别特异性相互作用的影响研究
Kelly M Jardon,Gijs H Goossens,Jasper Most et al.
Kelly M Jardon et al.
Polyphenols exert beneficial effects on host metabolism, which may be mediated by the gut microbiota. We investigated sex-specific differences in microbiota composition and interactions with cardiometabolic parameters after polyphenol suppl...
Randomized Controlled Trial
Gut microbes. 2024 Jan-Dec;16(1):2392875. DOI:10.1080/19490976.2024.2392875 2024