Segmental patterning of microbiota and immune cells in the murine intestinal tract [0.03%]
小鼠肠道菌群和免疫细胞的区段分布规律研究
Harithaa Anandakumar,Ariana Rauch,Moritz I Wimmer et al.
Harithaa Anandakumar et al.
The intestine exhibits distinct characteristics along its length, with a substantial immune cell reservoir and diverse microbiota crucial for maintaining health. This study investigates how anatomical location and regional microbiota influe...
Microbiome 2.0: lessons from the 2024 Gut Microbiota for Health World Summit [0.03%]
微生物组2.0：2024年肠道微生态国际峰会的启示
Sushrut Jangi,Gail Hecht
Sushrut Jangi
This Meeting Summary highlights the key insights from the 12th meeting of the Gut Microbiota for Health World Summit, held in Washington, DC, organized by the American Gastroenterological Association (AGA) and the European Society of Neurog...
Inflammation promotes stomach epithelial defense by stimulating the secretion of antimicrobial peptides in the mucus [0.03%]
炎症通过刺激黏液中抗菌肽的分泌促进胃上皮防御作用
Megi Vllahu,Antonia Voli,Valerio Licursi et al.
Megi Vllahu et al.
The mucus serves as a protective barrier in the gastrointestinal tract against microbial attacks. While its role extends beyond merely being a physical barrier, the extent of its active bactericidal properties remains unclear, and the mecha...
Protection against fibrosis by a bacterial consortium in metabolic dysfunction-associated steatohepatitis and the role of amino acid metabolism [0.03%]
一种细菌联合体通过调控氨基酸代谢对代谢紊乱相关steatohepatitis和肝纤维化的预防作用
Suet-Ying Kwan,Kristyn A Gonzales,Mohamed A Jamal et al.
Suet-Ying Kwan et al.
The gut microbiota drives progression to liver fibrosis, the main determinant of mortality in metabolic dysfunction-associated steatohepatitis (MASH). In this study, we aimed to identify bacterial species associated with protection against ...
The hidden base of the iceberg: gut peptidoglycome dynamics is foundational to its influence on the host [0.03%]
冰山隐藏的基础：肠道肽聚糖组的动态变化是其对宿主产生影响的基础
Richard Wheeler,Ivo Gomperts Boneca
Richard Wheeler
The intestinal microbiota of humans includes a highly diverse range of bacterial species. All these bacteria possess a cell wall, composed primarily of the macromolecule peptidoglycan. As such, the gut also harbors an abundant and varied pe...
MRGM: an enhanced catalog of mouse gut microbial genomes substantially broadening taxonomic and functional landscapes [0.03%]
MRGM：一个增强版的小鼠肠道微生物基因目录，大幅拓宽了分类和功能景观
Nayeon Kim,Chan Yeong Kim,Junyeong Ma et al.
Nayeon Kim et al.
Mouse gut microbiome research is pivotal for understanding the human gut microbiome, providing insights into disease modeling, host-microbe interactions, and the dietary influence on the gut microbiome. To enhance the translational value of...
Benefits and concerns of probiotics: an overview of the potential genotoxicity of the colibactin-producing Escherichia coli Nissle 1917 strain [0.03%]
益生菌的利弊：潜在致突变的大肠杆菌Nissle 1917菌株产生的一种colibactin的概述
Luca Falzone,Alessandro Lavoro,Saverio Candido et al.
Luca Falzone et al.
Recently, the mounting integration of probiotics into human health strategies has gathered considerable attention. Although the benefits of probiotics have been widely recognized in patients with gastrointestinal disorders, immune system mo...
Bile acids impact the microbiota, host, and C. difficile dynamics providing insight into mechanisms of efficacy of FMTs and microbiota-focused therapeutics [0.03%]
胆汁酸影响微生物组、宿主和艰难梭菌动态提供粪便微生物移植和以微生物群为重点的治疗机制的见解
Arthur S McMillan,Casey M Theriot
Arthur S McMillan
Clostridioides difficile is a major nosocomial pathogen, causing significant morbidity and mortality worldwide. Antibiotic usage, a major risk factor for Clostridioides difficile infection (CDI), disrupts the gut microbiota, allowing C. dif...
Fecal let-7b and miR-21 directly modulate the intestinal microbiota, driving chronic inflammation [0.03%]
粪便中的let-7b和miR-21可直接调节肠道微生物群，从而促发慢性炎症反应
Maite Casado-Bedmar,Maryline Roy,Louis Berthet et al.
Maite Casado-Bedmar et al.
Inflammatory bowel diseases (IBD) etiology is multifactorial. Luminal microRNAs (miRNAs) have been suspected to play a role in the promotion of chronic inflammation, but the extent to which fecal miRNAs are interacting with the intestinal e...
Ethanol-induced changes to the gut microbiome compromise the intestinal homeostasis: a review [0.03%]
乙醇通过改变肠道菌群来破坏肠内稳态：综述
Konrad Sosnowski,Adam Przybyłkowski
Konrad Sosnowski
The intestine is the largest organ in terms of surface area in the human body. It is responsible not only for absorbing nutrients but also for protection against the external world. The gut microbiota is essential in maintaining a properly ...