ADP-heptose attenuates Helicobacter pylori-induced dendritic cell activation [0.03%]
ADP-庚糖削弱Helicobacter pylori诱导的树突状细胞活化
Theresa Neuper,Tobias Frauenlob,Hieu-Hoa Dang et al.
Theresa Neuper et al.
Sophisticated immune evasion strategies enable Helicobacter pylori (H. pylori) to colonize the gastric mucosa of approximately half of the world's population. Persistent infection and the resulting chronic inflammation are a major cause of ...
Empowering probiotics with high xanthine transport for effective hyperuricemia management [0.03%]
高效运輸黄嘌呤益生菌促进高尿酸血症治疗及产业化示范项目
Zhen-Ping Zou,Ju-Ling Li,Yi-Fan Zhang et al.
Zhen-Ping Zou et al.
Hyperuricemia, a prevalent metabolic disorder, poses a susceptibility to various complications. The conventional pharmacotherapeutic approaches for hyperuricemia often entail notable adverse effects, posing substantial clinical challenges. ...
Prebiotic inulin controls Th17 cells mediated central nervous system autoimmunity through modulating the gut microbiota and short chain fatty acids [0.03%]
益生元低聚果糖通过调节肠道菌群和短链脂肪酸控制Th17介导的中枢神经系统自身免疫病
Ning Li,Xinyan Han,Ming Ruan et al.
Ning Li et al.
Multiple sclerosis (MS) is an autoimmune disease characterized by inflammatory demyelination occurring in the central nervous system (CNS). Inulin is a common prebiotic that can improve metabolic disorders by modulating the gut microbiota. ...
Gut microbe-host interactions in post-COVID syndrome: a debilitating or restorative partnership? [0.03%]
肠道微生物与宿主在新冠后遗症中的相互作用：一种令人衰弱的或恢复性的伙伴关系吗？
Torsten P M Scheithauer,Roy C Montijn,Arnout Mieremet
Torsten P M Scheithauer
Post-COVID syndrome (PCS) patients have reported a wide range of symptoms, including fatigue, shortness of breath, and diarrhea. Particularly, the presence of gastrointestinal symptoms has led to the hypothesis that the gut microbiome is in...
Effect of diet on the gut mycobiome and potential implications in inflammatory bowel disease [0.03%]
饮食对肠道真菌群（霉菌群）的影响及其在炎症性肠病中潜在的意义
J Buttar,E Kon,A Lee et al.
J Buttar et al.
The gut microbiome is a complex, unique entity implicated in the prevention, pathogenesis, and progression of common gastrointestinal diseases. While largely dominated by bacterial populations, advanced sequencing techniques have identified...
Enterotoxigenic Escherichia coli heat labile enterotoxin affects neutrophil effector functions via cAMP/PKA/ERK signaling [0.03%]
热不稳定肠毒素影响肠道免疫微环境中的中性粒细胞效应功能
Jinglin Ma,Leen Hermans,Matthias Dierick et al.
Jinglin Ma et al.
Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal illness in humans and animals, induced by enterotoxins produced by these pathogens. Despite the crucial role of neutrophils in combatting bacterial infections, our under...
The interplay between gut microbiota, short-chain fatty acids, and implications for host health and disease [0.03%]
肠道微生物群、短链脂肪酸之间的相互作用及其对宿主健康和疾病的启示
Kallie E Hays,Jacob M Pfaffinger,Rebecca Ryznar
Kallie E Hays
Short-chain fatty acids (SCFAs) - acetate, propionate, and butyrate - are important bacterial fermentation metabolites regulating many important aspects of human physiology. Decreases in the concentrations of any or multiple SCFAs are assoc...
Gut microbiota-mediated C-sulfonate metabolism impairs the bioavailability and anti-cholestatic efficacy of andrographolide [0.03%]
肠道微生物介导的C-磺酸盐代谢损害andrographolide的生物利用度和抗胆汁淤积功效
Dafu Tang,Wanyu Hu,Bingxuan Fu et al.
Dafu Tang et al.
Cholestatic liver injury results from the accumulation of toxic bile acids in the liver, presenting a therapeutic challenge with no effective treatment available to date. Andrographolide (AP) has exhibited potential as a treatment for chole...
Fecal microbiota transplantation derived from mild cognitive impairment individuals impairs cerebral glucose uptake and cognitive function in wild-type mice: Bacteroidetes and TXNIP-GLUT signaling pathway [0.03%]
来自轻度认知障碍个体的粪菌移植可损害野生型小鼠的大脑葡萄糖摄取及认知功能：疣微菌门和TXNIP-GLUT信号通路
Tao Wang,Ling Hao,Kexin Yang et al.
Tao Wang et al.
Gut microbiome dysbiosis has been widely implicated in cognitive impairment, but the identity of the specific bacterial taxa and mechanisms are not fully elucidated. Brain glucose hypometabolism coincides with the cognitive decline. This st...
Gut microbiota mediate early life stress-induced social dysfunction and anxiety-like behaviors by impairing amino acid transport at the gut [0.03%]
肠道微生物通过破坏肠道氨基酸转运诱导早期生活压力引起的社会功能和焦虑样行为障碍
Jiushuang Zhu,Zhuoting Zhong,Lijie Shi et al.
Jiushuang Zhu et al.
Early life stress alters gut microbiota and increases the risk of neuropsychiatric disorders, including social deficits and anxiety, in the host. However, the role of gut commensal bacteria in early life stress-induced neurobehavioral abnor...