Changes in intestinal permeability and gut microbiota following diet-induced weight loss in patients with metabolic dysfunction-associated steatohepatitis and liver fibrosis [0.03%]
代谢功能障碍相关非酒精性脂肪肝患者通过节食诱导减重后肠道通透性和肠道菌群的改变
Dimitrios A Koutoukidis,Sandi Yen,Paula Gomez Castro et al.
Dimitrios A Koutoukidis et al.
Weight loss improves metabolic dysfunction-associated steatohepatitis (MASH). We investigated whether there were associated changes in intestinal permeability, short-chain fatty acids (SCFAs), and gut microbiota, which are implicated in the...
Bacterial extracellular vesicles at the interface of gut microbiota and immunity [0.03%]
肠道微生物群和免疫系统之间的细菌细胞外囊泡交互作用
Inês Melo-Marques,Sandra Morais Cardoso,Nuno Empadinhas
Inês Melo-Marques
Bacterial extracellular vesicles (BEVs) are nano-sized lipid-shielded structures released by bacteria and that play an important role in intercellular communication. Their broad taxonomic origins and varying cargo compositions suggest their...
FMT rescues mice from DSS-induced colitis in a STING-dependent manner [0.03%]
FMT通过STING依赖性方式可抢救DSS诱导的结肠炎小鼠
Dan Pu,Yao Yao,Chuan Zhou et al.
Dan Pu et al.
Fecal microbiota transplantation (FMT) is currently a promising therapy for inflammatory bowel disease (IBD). However, clinical studies have shown that there is an obvious individual difference in the efficacy of FMT. Therefore, it is a pre...
EspH utilizes phosphoinositide and Rab binding domains to interact with plasma membrane infection sites and Rab GTPases [0.03%]
EspH利用磷脂肌醇和Rab结合域与质膜感染位点及Rab小G蛋白相互作用
Ipsita Nandi,Rachana Pattani Ramachandran,Deborah E Shalev et al.
Ipsita Nandi et al.
Enteropathogenic E. coli (EPEC) is a Gram-negative bacterial pathogen that causes persistent diarrhea. Upon attachment to the apical plasma membrane of the intestinal epithelium, the pathogen translocates virulence proteins called effectors...
Intestinal deguelin drives resistance to acetaminophen-induced hepatotoxicity in female mice [0.03%]
肠丁公亭素驱动雌性小鼠对抗乙酰氨基酚引起的肝毒性
Shenhai Gong,Yunong Zeng,Ze Wang et al.
Shenhai Gong et al.
Acetaminophen (APAP) overdose is a leading cause of drug-induced liver injury (DILI), with gender-specific differences in susceptibility. However, the mechanism underlying this phenomenon remains unclear. Our study reveals that the gender-s...
A new perspective in intestinal microecology: lifting the veil of exercise regulation of cardiometabolic diseases [0.03%]
肠道微生态学的新视角：揭开运动调节心血管代谢疾病的面纱
Can Gao,Jinwen Wei,Changxu Lu et al.
Can Gao et al.
Cardiometabolic diseases (CMDs), encompassing cardiovascular and metabolic dysfunctions, characterized by insulin resistance, dyslipidemia, hepatic steatosis, and inflammation, have been identified with boosting morbidity and mortality due ...
Maria E Panzetta,Raphael H Valdivia
Maria E Panzetta
Akkermansia sp are common members of the human gut microbiota. Multiple reports have emerged linking the abundance of A. muciniphila to health benefits and disease risk in humans and animals. This review highlights findings linking Akkerman...
End-to-end donor screening and manufacturing controls: complementary quality-based strategies to minimize patient risk for donor-derived microbiome therapeutics [0.03%]
供者筛选及生产管控的全流程策略：降低捐赠微生物疗法患者风险的质量控制措施
Jason Goldsmith,Sarah Tomkovich,John G Auniņš et al.
Jason Goldsmith et al.
Advances in microbiome therapeutics have been motivated by a deeper understanding of the role that the gastrointestinal microbiome plays in human health and disease. The FDA approval of two stool-derived live biotherapeutic products (LBPs),...
Molecular serotyping of diarrheagenic Escherichia coli with a MeltArray assay reveals distinct correlation between serotype and pathotype [0.03%]
一种用于分子血清型分型的熔解曲线阵列检测方法揭示了腹泻致病性大肠杆菌血清型与毒力型之间的相关性
Chen Du,Yiqun Liao,Congcong Ding et al.
Chen Du et al.
Diarrheagenic Escherichia coli serotypes are associated with various clinical syndromes, yet the precise correlation between serotype and pathotype remains unclear. A major barrier to such studies is the reliance on antisera-based serotypin...
Gut microbiota-derived butyrate selectively interferes with growth of carbapenem-resistant Escherichia coli based on their resistance mechanism [0.03%]
肠菌源丁酸盐通过耐药机制选择性抑制碳青霉烯耐药大肠埃希氏杆菌生长
Eva Happ,Kora Schulze,Zinia Afrin et al.
Eva Happ et al.
We investigated consequences of resistance acquisition in Escherichia coli clinical isolates during anaerobic (continuous culture) growth and examined their sensitivity to butyrate, a hallmark metabolite of healthy gut microbiota. Strains w...