Morphine-induced intestinal microbial dysbiosis drives TLR-dependent IgA targeting of gram-positive bacteria and upregulation of CD11b and TLR2 on a sub-population of IgA+ B cells [0.03%]
吗啡致肠道微生物群失调驱动TLR依赖的IgA靶向抗阳性菌的作用并上调CD11b和TLR2在IgA+B细胞亚群中表达
Nicolas Vitari,Salma Singh,Junyi Tao et al.
Nicolas Vitari et al.
IgA binding dictates the composition of the intestinal microbiome and reflects dysbiotic states during chronic disease. Both pathogenic and commensal bacteria differentially bind to IgA with varying outcomes. Little is known regarding IgA d...
Fecal samples and rectal swabs adequately reflect the human colonic luminal microbiota [0.03%]
粪便样本和直肠拭子能够充分反映人类结肠腔内的微生物群状态
Julia Rode,Linnea Brengesjö Johnson,Julia König et al.
Julia Rode et al.
The appropriateness of the fecal microbiota to adequately reflect the gut microbiota composition from more difficult to access luminal content at different colonic locations has been debated. Here, in a healthy population, luminal samples w...
Maria Lucia Orsini Delgado,Joao Gamelas Magalhaes,Rachel Morra et al.
Maria Lucia Orsini Delgado et al.
In bacteria, the cell envelope is the key element surrounding and protecting the bacterial content from mechanical or osmotic damages. It allows the selective interchanges of solutes, ions, cellular debris, and drugs between the cellular co...
Species- and subspecies-level characterization of health-associated bacterial consortia that colonize the human gut during infancy [0.03%]
婴儿肠道菌群的物种及亚种水平特征研究
Samuel S Minot,Koshlan Mayer-Blackwell,Andrew Fiore-Gartland et al.
Samuel S Minot et al.
Background: The human gut microbiome develops rapidly during infancy, a key window of development coinciding with the maturation of the adaptive immune system. However, little is known about the microbiome growth dynamics...
Inflammasome activation links enteric Salmonella Typhimurium infection to a rapid, cytokine-dependent increase in intestinal mucin release [0.03%]
炎症小体激活可将肠炎沙门氏菌感染与快速的细胞因子依赖型肠粘液释放增加相联系
Xiao Han,Joannie M Allaire,Shauna M Crowley et al.
Xiao Han et al.
The host restricts Salmonella enterica serovar Typhimurium infection of the gut via inflammasome-dependent sloughing of infected epithelial cells. Here we determined that concurrent caspase 1/11-dependent release of the goblet cell-derived ...
Gut microbial metabolic signatures in diabetes mellitus and potential preventive and therapeutic applications [0.03%]
糖尿病的肠道微生物代谢标志物及潜在预防和治疗应用
Enriqueta Garcia-Gutierrez,A Kate O&#x;Mahony,Reinaldo Sousa Dos Santos et al.
Enriqueta Garcia-Gutierrez et al.
Diabetes mellitus can be subdivided into several categories based on origin and clinical characteristics. The most common forms of diabetes are type 1 (T1D), type 2 diabetes (T2D) and gestational diabetes mellitus (GDM). T1D and T2D are chr...
Gut microbiota determines the fate of dietary fiber-targeted interventions in host health [0.03%]
肠道微生物组决定了膳食纤维靶向干预在宿主健康中的命运
Wenjing Wang,Zhexin Fan,Qingqing Yan et al.
Wenjing Wang et al.
Epidemiological investigation confirmed that the intake of dietary fiber (DF) is closely related to human health, and the most important factor affecting the physiological function of DF, besides its physicochemical properties, is the gut m...
Giardia spp.-induced microbiota dysbiosis disrupts intestinal mucin glycosylation [0.03%]
溶组织内阿米巴通过破坏肠道黏蛋白糖基化诱导微生物群紊乱
Elena Fekete,Thibault Allain,Olivia Sosnowski et al.
Elena Fekete et al.
Infection with the protozoan parasite Giardia duodenalis (syn. intestinalis, lamblia) has been associated with intestinal mucus disruptions and microbiota dysbiosis. The mechanisms remain incompletely understood. Mucus consists primarily of...
Controlled infection with cryopreserved human hookworm induces CTLA-4 expression on Tregs and upregulates tryptophan metabolism [0.03%]
冻存的钩虫感染致CTLAl在Tregs表达上调及色氨酸分解代谢增强
Francesco Vacca,Thomas C Mules,Mali Camberis et al.
Francesco Vacca et al.
Infecting humans with controlled doses of helminths, such as human hookworm (termed hookworm therapy), is proposed to prevent or treat various intestinal and extraintestinal diseases. However, full-scale clinical trials examining hookworm t...
High-fat diet-induced L-saccharopine accumulation inhibits estradiol synthesis and damages oocyte quality by disturbing mitochondrial homeostasis [0.03%]
高脂饮食诱导的L-色氨醇积累通过干扰线粒体稳态抑制雌二醇合成并损害卵母细胞质量
Jingyi Wen,Yanzhi Feng,Liru Xue et al.
Jingyi Wen et al.
High-fat diet (HFD) has been linked to female infertility. However, the specific age at which HFD impacts ovarian function and the underlying mechanisms remain poorly understood. Here, we administered a HFD to female mice at various develop...