Sheng Liu,Zhao Zhang,Xudong Wang et al.
Sheng Liu et al.
Gut microbiome plays a pivotal role in combating diseases and facilitating healthy aging, and natural products derived from biosynthetic gene clusters (BGCs) of the human microbiome exhibit significant biological activities. However, the na...
Immunogenicity and cross-protective efficacy induced by delayed attenuated Salmonella with regulated length of lipopolysaccharide in mice [0.03%]
延迟型调控脂多糖长度沙门菌载体疫苗的免疫原性及交叉保护效力研究
Xiaoping Bian,Qing Liu,Yaolin Chen et al.
Xiaoping Bian et al.
Non-typhoidal Salmonella enterica (NTS) is a major global foodborne pathogen that poses a major public health concern worldwide, and no vaccines are available for protecting against infection of multiple Salmonella serotypes, therefore, the...
KRAS mutations promote the intratumoral colonization of enterotoxigenic bacteroides fragilis in colorectal cancer through the regulation of the miRNA3655/SURF6/IRF7/IFNβ axis [0.03%]
KRAS突变通过微调miRNA3655/SURF6/IRF7/IFNβ轴促进肠道脆弱类杆菌在结直肠癌瘤内的定植
Yizhen Chen,Shaolin Liu,Song Tan et al.
Yizhen Chen et al.
KRAS mutations are associated with poor prognosis in colorectal cancer (CRC). Although the association between the gut microbiota and CRC has been extensively documented, it is unclear whether KRAS mutations can regulate the gut microbiota....
Reverse engineering the Gut-Brain Axis and microbiome-metabolomics for symbiotic/pathogenic balance in neurodegenerative diseases [0.03%]
肠道微生物组与代谢组在神经退行性疾病中互益/致病平衡的反向工程及肠脑轴研究
Muhammad Usman Munir,Syed Aoun Ali,Ka Hang Karen Chung et al.
Muhammad Usman Munir et al.
Deciphering the molecular communications along the gut-brain axis can help in understanding the pathophysiology of neurodegenerative diseases and exploiting the gut microbiome for therapeutics. However, gut microbes and their metabolites ha...
Impact of an intranasal L-DBF vaccine on the gut microbiota in young and elderly mice [0.03%]
鼻内L-DBF疫苗对小鼠年轻和年老个体肠道菌群的影响
Ti Lu,Aaron C Ericsson,Zackary K Dietz et al.
Ti Lu et al.
Shigella spp. cause bacillary dysentery (shigellosis) with high morbidity and mortality in low- and middle-income countries. Infection occurs through the fecal-oral route and can be devastating for vulnerable populations, including infants ...
Intestinal flora: a potential pathogenesis mechanism and treatment strategy for type 1 diabetes mellitus [0.03%]
肠道菌群：1型糖尿病发病机制及治疗策略的新思路
Shengnan Huang,Fangfang Li,Chunhua Quan et al.
Shengnan Huang et al.
Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by destruction of pancreatic β-cells, leading to insulin deficiency and hyperglycemia, and its incidence is increasing year by year. The pathogenesis of T1DM is ...
Dingjiacheng Jia,Shujie Chen
Dingjiacheng Jia
Fusobacterium nucleatum can promote colorectal cancer (CRC) development through a variety of virulence proteins. Zhang et al. recently identified an adhesin RadD, for Fusobacterium nucleatum adhesion to CRC. Targeting the interaction betwee...
Colonization resistance: the role of gut microbiota in preventing Salmonella invasion and infection [0.03%]
肠菌屏障作用：肠道菌群抵抗沙门氏菌定植和感染的功能
Lei Deng,Shaohui Wang
Lei Deng
The human gastrointestinal tract is colonized by a complex microbial ecosystem, the gut microbiota, which is pivotal in maintaining host health and mediating resistance to diseases. This review delineates colonization resistance (CR), a cri...
Clostridium innocuum, an opportunistic gut pathogen, inactivates host gut progesterone and arrests ovarian follicular development [0.03%]
脆弱拟杆菌失活宿主肠道孕酮并抑制卵巢卵泡发育
Mei-Jou Chen,Chia-Hung Chou,Tsun-Hsien Hsiao et al.
Mei-Jou Chen et al.
/Levels of progesterone, an endogenous female hormone, increase after ovulation; progesterone is crucial in the luteal phase to maintain successful pregnancy and prevent early miscarriage. Both endogenous and exogenous progesterone are recy...
PPARα exacerbates Salmonella Typhimurium infection by modulating the immunometabolism and macrophage polarization [0.03%]
PPARα通过调节免疫代谢和巨噬细胞极化加剧伤寒沙门氏菌感染
Jessica R Taddeo,Naomi Wilson,Anita Kowal et al.
Jessica R Taddeo et al.
Salmonella enterica serovar Typhimurium (STm) is a causative pathogen for robust inflammatory gastrointestinal disease and can lead to systemic infection. Eicosanoids, bioactive lipid mediators, play a crucial role in modulating both the in...