Microbiota-derived small molecule genotoxins: host interactions and ecological impact in the gut ecosystem [0.03%]
肠道微生物群来源的小分子致突变毒素：宿主互作及对肠道生态系统的影响
Ellen L Zechner,Sabine Kienesberger
Ellen L Zechner
The human intestinal tract is densely colonized by a microbial community that is subject to intense competition. Bacteria in this complex habitat seek to outcompete their neighbors for nutrients and eliminate competitors with antibacterial ...
Effects of gastric bypass bariatric surgery on gut microbiota in patients with morbid obesity [0.03%]
胃旁路代谢手术对病态肥胖患者肠道菌群的影响
Urja Amin,Dora Huang,Arun Dhir et al.
Urja Amin et al.
The Western diet is associated with gastrointestinal dysbiosis, an active contributor to the pathophysiology of obesity and its comorbidities. Gastrointestinal dysbiosis is strongly linked to increased adiposity, low-grade inflammation, dys...
Dysrupted microbial tryptophan metabolism associates with SARS-CoV-2 acute inflammatory responses and long COVID [0.03%]
紊乱的微生物色氨酸代谢与SARS-CoV-2急性炎症反应和长新冠相关性研究
Lu Yao,Hannah Devotta,Junhui Li et al.
Lu Yao et al.
Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and risk of long COVID has been associated with the depletion or over-abundance of specific taxa within the gut microbiome. However, the microbial mec...
Prebiotics in food and dietary supplements: a roadmap to EU health claims [0.03%]
食品和膳食补充剂中的益生元与欧盟健康声明：未来之路
Kieran Tuohy,Elaine E Vaughan,Lucien F Harthoorn et al.
Kieran Tuohy et al.
Numerous studies have established that prebiotic ingredients in foods and dietary supplements may play a role in supporting human health. Over the three decades that have passed since prebiotics were first defined as a concept, research has...
Induction of intercrypt goblet cells upon bacterial infection: a promising therapeutic target to restore the mucosal barrier [0.03%]
细菌感染诱导肠上皮杯状细胞增生：重建粘膜屏障的潜在治疗靶点
Renaud Léonard,Ewa Pasquereau-Kotula,Edwige Madec et al.
Renaud Léonard et al.
Intestinal mucins play a crucial role in the mucosal barrier, serving as the body's initial defense against microorganisms. However, how the host regulates the secretion and glycosylation of these mucins in response to bacterial invasion re...
Mechanisms of gut bacterial metabolism of dietary polyphenols into bioactive compounds [0.03%]
饮食多酚通过肠道细菌代谢成为活性化合物的机制研究进展
Sara Alqudah,Jan Claesen
Sara Alqudah
The fruits and vegetables we consume as part of our diet are rich in bioactive metabolites that can prevent and ameliorate cardiometabolic diseases, cancers, and neurological conditions. Polyphenols are a major metabolite family that has be...
Lactic acid bacteria derived extracellular vesicles: emerging bioactive nanoparticles in modulating host health [0.03%]
源自乳酸菌的胞外囊泡：调节宿主健康的新型生物活性纳米粒子
Mohan Li,Bingyong Mao,Xin Tang et al.
Mohan Li et al.
Lactic acid bacteria derived extracellular vesicles (LAB-EVs) are nano-sized and carry a variety of biological cargoes. LAB-EVs have proven to be potential mediators of intercellular communication, serving not only the parental bacteria but...
Differential contributions of the gut microbiota and metabolome to pathomechanisms in ulcerative colitis: an in vitro analysis [0.03%]
肠道微生物组和代谢组在溃疡性结肠炎发病机制中的不同作用：体外分析
Jonas Poppe,Leen Boesmans,Sara Vieira-Silva et al.
Jonas Poppe et al.
The gut microbiota has been implicated in onset and progression of ulcerative colitis (UC). Here, we assess potential causal involvement of the microbiota and -associated fecal water (FW) metabolome in altering key functional parameters of ...
Gut microbial metabolism of bile acids modifies the effect of Mediterranean diet interventions on cardiometabolic risk in a randomized controlled trial [0.03%]
肠道微生物代谢胆酸可改变地中海饮食干预对心血管代谢风险影响的随机对照试验
Peipei Gao,Ehud Rinott,Danyue Dong et al.
Peipei Gao et al.
Bile acids (BAs) undergo extensive microbial metabolism in the gut and exert hormone-like functions on physiological processes underlying metabolic risk. However, the extent to which gut BA profiles predict cardiometabolic risk and explain ...
Randomized Controlled Trial
Gut microbes. 2024 Jan-Dec;16(1):2426610. DOI:10.1080/19490976.2024.2426610 2024
Stability in fecal metabolites amid a diverse gut microbiome composition: a one-month longitudinal study of variability in healthy individuals [0.03%]
基于健康个体为期一个月纵向变化的粪便代谢物稳定性的研究：多样化的肠道微生物群组成的视角
Matteo Sangermani,Indri Desiati,Solveig M Jørgensen et al.
Matteo Sangermani et al.
An extensive network of microbial-host interactions exists in the gut, making the gut microbiome a complex ecosystem to untangle. The microbial composition and the fecal metabolites are important readouts to investigate intricate microbiota...