Symptom-specific gut microbial and metabolic profiles in ADHD reveal SCFA deficiency as a Key pathogenic mechanism [0.03%]
ADHD的症状特异性肠道微生物和代谢特征揭示SCFA缺乏是关键的致病机制
Xinyue Wang,Ning Wang,Teng Gao et al.
Xinyue Wang et al.
Previous evidence links gut microbiota to attention-deficit/hyperactivity disorder (ADHD) through the gut-brain axis. However, the specific microbiota contributing to symptoms remain unclear. To characterize the gut microbial profile relate...
Dietary cholesterol impairs cognition via gut microbiota-derived deoxycholic acid in obese mice [0.03%]
饮食胆固醇通过肠道微生物群衍生的脱氧胆酸损害肥胖小鼠的认知功能
Yan Liu,Zhangtie Wang,Yansong Zhang et al.
Yan Liu et al.
Dietary cholesterol is often found in a high-fat diet (HFD) and excessive intake is harmful to cognitive function. The gut microbiome constitutes an environmental factor influenced by diet, which regulates cognitive function via the gut-bra...
Interplay of miR-243 and microbial interactions in aging and transgenerational immunity [0.03%]
miR-243与微生物互作在衰老和跨世代免疫中的作用关系研究
Arun Kumar,Dilawar A Mir,Mojibur R Khan
Arun Kumar
MicroRNAs (miRNAs) function in post-transcriptional regulation of gene expression and influence numerous biological processes. This commentary and view provide integrated insights from Kumar et al. (2024) and Gabaldon et al. (2020), emphasi...
Ruijie Bai,Tao Wang,Rongrong Gu et al.
Ruijie Bai et al.
The co-evolutionary relationship between gut microbiota and their hosts is influenced by microbial genetic variation, which enables adaptation to host environmental changes, modifies metabolic processes, and refines host-microbiota interact...
Blood-borne immune cells carry low biomass DNA remnants of microbes in patients with colorectal cancer or inflammatory bowel disease [0.03%]
血液源性免疫细胞携带低生物量dna微生物片段与结直肠癌或炎症性肠病的关系
Yasser Morsy,Åsa Walberg,Paulina Wawrzyniak et al.
Yasser Morsy et al.
The involvement of the intestinal microbiome in the pathogenesis of inflammatory bowel disease (IBD) and colorectal cancer (CRC), is well-established. Bacteria interact with immune cells at sites of intestinal inflammation, but also in the ...
Genome-scale metabolic modelling of human gut microbes to inform rational community design [0.03%]
基因尺度的人类肠道微生物代谢模型合理构建社区
Juan Pablo Molina Ortiz,Dale David McClure,Andrew Holmes et al.
Juan Pablo Molina Ortiz et al.
The human gut microbiome impacts host health through metabolite production, notably short-chain fatty acids (SCFAs) derived from digestion-resistant carbohydrates (DRCs). While DRC supplementation offers a means to modulate the microbiome t...
Deciphering the microbiome-metabolome landscape of an inflammatory bowel disease inception cohort [0.03%]
炎症性肠病起始队列的微生物组-代谢组谱系解析
Shiva T Radhakrishnan,Benjamin H Mullish,Marton L Olbei et al.
Shiva T Radhakrishnan et al.
The gut microbiota contribute to the etiopathogenesis of inflammatory bowel disease (IBD), but limitations of prior studies include the use of sequencing alone (restricting exploration of the contribution of microbiota functionality) and th...
Ginger-derived vesicle-like nanoparticles loaded with curcumin to alleviate ionizing radiation-induced intestinal damage via gut microbiota regulation [0.03%]
姜黄素衍生物类似囊泡的纳米颗粒通过调节肠道菌群缓解放射引起的肠损伤
Xinrui Zhang,Qian Cui,Li Yin et al.
Xinrui Zhang et al.
Emerging insights have been approached that gut microbiota act as a critical regulator for ionizing radiation (IR)-induced damage. Herein, an available strategy has been explored to shape gut microbiota for radioprotection by loading curcum...
Secretory IgA dysfunction underlies poor prognosis in Fusobacterium-infected colorectal cancer [0.03%]
弗氏杆菌感染的结直肠癌患者预后不良与分泌型免疫球蛋白A功能障碍有关
Ilseok Choi,Kyung-A Kim,Sang Cheol Kim et al.
Ilseok Choi et al.
Fusobacterium nucleatum (Fn) is commonly enriched in colorectal cancer (CRC) and associated with poor outcomes, though its mechanisms remain unclear. Our study investigated how Fn affects the tumor microenvironment through single-cell trans...
Gut microbiota and tuberculosis infection: interaction and therapeutic potential [0.03%]
肠道微生物群和结核分枝杆菌感染：相互作用与治疗潜力
Yinghui Chai,Min Li,Xianping Deng et al.
Yinghui Chai et al.
Pulmonary tuberculosis (PTB), caused by Mycobacterium tuberculosis (MTB), is a serious chronic infectious disease. Although significant progress has been made in the prevention and treatment of MTB, current anti-tuberculosis therapies still...