Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation [0.03%]
白藜芦醇通过激活Sirtuin1信号通路预防肠道菌群脱氢苯乙酸导致的肥胖作用机制研究
Pan Wang,Ruiqi Wang,Wenting Zhao et al.
Pan Wang et al.
Resveratrol (RSV), a natural polyphenol, has been suggested to influence glucose and lipid metabolism. However, the underlying molecular mechanism of its action remains largely unknown due to its multiple biological targets and low bioavail...
Gut microbes with the gbu genes determine TMAO production from L-carnitine intake and serve as a biomarker for precision nutrition [0.03%]
肠道携带GBU基因的微生物可将左旋肉碱摄取转化为三甲胺-N-氧化物，并作为精准营养生物标志物
Wei-Kai Wu,Yi-Ling Lo,Jian-Ying Chiu et al.
Wei-Kai Wu et al.
Gut microbial metabolism of L-carnitine, which leads to the production of detrimental trimethylamine N-oxide (TMAO), offers a plausible link between red meat consumption and cardiovascular risks. Several microbial genes, including cntA/B, t...
Fusobacterium sphaericum sp. nov., isolated from a human colon tumor adheres to colonic epithelial cells and induces IL-8 secretion [0.03%]
解乳球形菌四型是从来自结肠肿瘤的样本中分离得到的一种新的口腔球形菌种类，可黏附到结肠上皮细胞并诱导白介素-8分泌
Martha A Zepeda-Rivera,Yannick Eisele,Alexander Baryiames et al.
Martha A Zepeda-Rivera et al.
Cancerous tissue is a largely unexplored microbial niche that provides a unique environment for the colonization and growth of specific bacterial communities, and with it, the opportunity to identify novel bacterial species. Here, we report...
Clostridioides difficile binary toxin CDT induces biofilm-like persisting microcolonies [0.03%]
难辨芽孢梭菌二元毒素CDT诱导生物被膜样的持续微菌落形成
Jazmin Meza-Torres,Jean-Yves Tinevez,Aline Crouzols et al.
Jazmin Meza-Torres et al.
Clinical symptoms of Clostridioides difficile infection (CDI) range from diarrhea to pseudomembranous colitis. A major challenge in managing CDI is the high rate of relapse. Several studies correlate the production of CDT binary toxin by cl...
Desulfovibrio vulgaris flagellin exacerbates colorectal cancer through activating LRRC19/TRAF6/TAK1 pathway [0.03%]
脱硫弧菌鞭毛蛋白通过激活LRRC19/TRAF6/TAK1信号加重结直肠癌
Yue Dong,Fanyi Meng,Jingyi Wang et al.
Yue Dong et al.
The initiation and progression of colorectal cancer (CRC) are intimately associated with genetic, environmental and biological factors. Desulfovibrio vulgaris (DSV), a sulfate-reducing bacterium, has been found excessive growth in CRC patie...
Identifying the location-dependent adipose tissue bacterial DNA signatures in obese patients that predict body weight loss [0.03%]
预测体重减轻的肥胖患者位置依赖性脂肪组织细菌DNA标志物的鉴定
Matthieu Minty,Alberic Germain,Jiuwen Sun et al.
Matthieu Minty et al.
Recent sets of evidence have described profiles of 16S rDNA sequences in host tissues, notably in fat pads that are significantly overrepresented and can serve as signatures of metabolic disease. However, these recent and original observati...
Development of a Caco-2-based intestinal mucosal model to study intestinal barrier properties and bacteria-mucus interactions [0.03%]
基于Caco-2的肠粘膜模型的发展，用于研究肠道屏障性质和细菌-粘液相互作用
Evelien Floor,Jinyi Su,Maitrayee Chatterjee et al.
Evelien Floor et al.
The intestinal mucosal barrier is a dynamic system that allows nutrient uptake, stimulates healthy microbe-host interactions, and prevents invasion by pathogens. The mucosa consists of epithelial cells connected by cellular junctions that r...
A modelling framework to characterize the impact of antibiotics on the gut microbiota diversity [0.03%]
一个表征抗生素对肠道微生物多样性影响的模型框架
Carlos Olivares,Etienne Ruppé,Stéphanie Ferreira et al.
Carlos Olivares et al.
Metagenomic sequencing deepened our knowledge about the role of the intestinal microbiota in human health, and several studies with various methodologies explored its dynamics during antibiotic treatments. We compared the impact of four wid...
Fusobacterium nucleatum-driven CX3CR1+ PD-L1+ phagocytes route to tumor tissues and reshape tumor microenvironment [0.03%]
牙龈卟啉单胞菌驱动的CX3CR1+PD-L1+吞噬细胞迁移到肿瘤组织并重塑肿瘤微环境
Fangfang Chen,Songhe Guo,Yiqiu Li et al.
Fangfang Chen et al.
The intracellular bacterium Fusobacterium nucleatum (Fn) mediates tumorigenesis and progression in colorectal cancer (CRC). However, the origin of intratumoral Fn and the role of Fn-infected immunocytes in the tumor microenvironment remain ...
Maternal probiotic exposure enhances CD8 T cell protective neonatal immunity and modulates offspring metabolome to control influenza virus infection [0.03%]
母体益生菌暴露增强新生儿CD8 T细胞的保护性免疫力并调节后代代谢组以控制流感病毒感染
Clara Valentin,Patricia Brito Rodrigues,Marko Verce et al.
Clara Valentin et al.
Maternal gut microbiota composition contributes to the status of the neonatal immune system and could influence the early life higher susceptibility to viral respiratory infections. Using a novel protocol of murine maternal probiotic supple...