Lactiplantibacillus plantarum (CECT7484 and CECT7485) and Pedioccoccus acidilactici (CECT7483) enhance actin cytoskeleton and CYP1A1 expression restoring epithelial permeability alterations induced by irritable bowel syndrome mediators [0.03%]
肠易激综合征介质诱导的上皮通透性改变由Lactiplantibacillus plantarum（CECT7484和CECT7485）和Pedioccoccus acidilactici（CECT7483）恢复胶状细胞骨架和CYP1A1表达增强所致
Maria Raffaella Barbaro,Francesca Bianco,Cesare Cremon et al.
Maria Raffaella Barbaro et al.
Irritable bowel syndrome (IBS) is a multifactorial condition with heterogeneous pathophysiology, including intestinal permeability alterations. The aim of the present study was to assess the ability of a probiotic blend (PB) consisting of t...
Single-cell microbiota phenotyping reveals distinct disease and therapy-associated signatures in Crohn's disease [0.03%]
单细胞微生物组表型分析揭示了克罗恩病中不同的疾病和治疗相关的标志物
Lisa Budzinski,Gi-Ung Kang,René Riedel et al.
Lisa Budzinski et al.
IgA-coated fractions of the intestinal microbiota of Crohn's disease (CD) patients have been shown to contain taxa that hallmark the compositional dysbiosis in CD microbiomes. However, the correlation between other cellular properties of in...
Failure of colonization following gut microbiota transfer exacerbates DSS-induced colitis [0.03%]
肠道菌群移植后结肠定植失败可加重DSS诱导的结肠炎
Kevin L Gustafson,Trevor R Rodriguez,Zachary L McAdams et al.
Kevin L Gustafson et al.
To study the impact of differing specific pathogen-free gut microbiomes (GMs) on a murine model of inflammatory bowel disease, selected GMs were transferred using embryo transfer (ET), cross-fostering (CF), and co-housing (CH). Prior work s...
Host-microbe multi-omics and succinotype profiling have prognostic value for future relapse in patients with inflammatory bowel disease [0.03%]
宿主微生物多组学和琥珀酸型谱对炎症性肠病患者未来复发的预测价值
Jill O&#x;Sullivan,Shriram Patel,Gabriel E Leventhal et al.
Jill O&#x;Sullivan et al.
Crohn's disease (CD) and ulcerative colitis (UC) are chronic relapsing inflammatory bowel disorders (IBD), the pathogenesis of which is uncertain but includes genetic susceptibility factors, immune-mediated tissue injury and environmental i...
Microbial succinate promotes the response to metformin by upregulating secretory immunoglobulin a in intestinal immunity [0.03%]
肠道微生物丁二酸通过上调分泌型免疫球蛋白a促进肠黏膜对二甲双胍的反应
Ying Zhang,Aiting Wang,Wei Zhao et al.
Ying Zhang et al.
Metformin is the first-line pharmacotherapy for type 2 diabetes mellitus; however, many patients respond poorly to this drug in clinical practice. The potential involvement of microbiota-mediated intestinal immunity and related signals in m...
Gut dysbiosis was inevitable, but tolerance was not: temporal responses of the murine microbiota that maintain its capacity for butyrate production correlate with sustained antinociception to chronic morphine [0.03%]
肠道失调不可避免，但耐受性不是：维持丁酸盐生产能力的小鼠微生物群的时间反应与慢性吗啡的持续镇痛作用相关联
Izabella Sall,Randi Foxall,Lindsey Felth et al.
Izabella Sall et al.
The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug dependence and addiction. Rodent models indicate o...
Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila [0.03%]
肠道乳酸通过Akkermansia muciniphila促进色氨酸向五羟色胺的转化以调节焦虑反应
Miaomiao Pan,Chenglang Qian,Shaoye Huo et al.
Miaomiao Pan et al.
The gut microbiota plays a pivotal role in anxiety regulation through pathways involving neurotransmitter production, immune signaling, and metabolic interactions. Among these, gut-derived serotonin (5-hydroxytryptamine, 5-HT), synthesized ...
Mouse strain-specific responses along the gut-brain axis upon fecal microbiota transplantation from children with autism [0.03%]
自闭症儿童粪菌移植后不同品系小鼠肠-脑轴应答的差异性研究
Naika Prince,Lucia N Peralta Marzal,Léa Roussin et al.
Naika Prince et al.
Several factors are linked to the pathophysiology of autism spectrum disorders (ASD); however, the molecular mechanisms of the condition remain unknown. As intestinal problems and gut microbiota dysbiosis are associated with ASD development...
Lactobacillus intestinalis facilitates tumor-derived CCL5 to recruit dendritic cell and suppress colorectal tumorigenesis [0.03%]
肠细菌乳酸菌肠道亚种通过促进肿瘤产生的CCL5募集树突状细胞来抑制结直肠肿瘤发生
Yong Sun,Qiwen Wang,Yao Jiang et al.
Yong Sun et al.
Gut microbes play a crucial role in regulating the tumor microenvironment (TME) of colorectal cancer (CRC). Nevertheless, the deep mechanism between the microbiota-TME interaction has not been well explored. In this study, we for the first ...
Gut dysbiosis-induced vitamin B6 metabolic disorder contributes to chronic stress-related abnormal behaviors in a cortisol-independent manner [0.03%]
肠道微生态失调诱发的维生素B6代谢紊乱通过糖皮质激素非依赖性方式参与慢性应激异常行为反应的发展
Wenxiang Qing,Huimin Chen,Xin Ma et al.
Wenxiang Qing et al.
Chronic stress can result in various conditions, including psychological disorders, neurodegenerative diseases, and accelerated brain aging. Gut dysbiosis potentially contributes to stress-related brain disorders in individuals with chronic...