Biofilm-associated proteins: from the gut biofilms to neurodegeneration [0.03%]
从肠道生物膜到神经退行性疾病：生物膜相关蛋白
Jaione Valle
Jaione Valle
Human microbiota form a biofilm with substantial consequences for health and disease. Numerous studies have indicated that microbial communities produce functional amyloids as part of their biofilm extracellular scaffolds. The overlooked in...
AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin 1 Leading to Reversal of Gut Microbiota Dysbiosis and Colitis [0.03%]
活化受体诱导 transcriptionally alpha-Defensin 1的生成从而导致肠道微生物群dysbiosis和结肠炎的产生
Manikandan Palrasu,Khadija Kakar,Amarnath Marudamuthu et al.
Manikandan Palrasu et al.
Alpha-defensin 1 is a small antimicrobial peptide that acts as the first line of defense against pathogens. It is induced following microbial cues and inflammatory signals in neutrophils and Paneth cells in the small intestine, which sugges...
PMA1-containing extracellular vesicles of Candida albicans triggers immune responses and colitis progression [0.03%]
白念珠菌含PMA1的细胞外囊泡诱导免疫反应和结肠炎恶化
Zhen Xu,Shuping Qiao,Zelin Wang et al.
Zhen Xu et al.
Candida albicans (C. albicans) exhibits aberrant changes in patients with colitis, and it has been reported to dominate the colonic mucosal immune response. Here, we found that PMA1 expression was significantly increased in C. albicans from...
Lachnospiraceae-bacterium alleviates ischemia-reperfusion injury in steatotic donor liver by inhibiting ferroptosis via the Foxo3-Alox15 signaling pathway [0.03%]
乳酸菌通过Foxo3-Alox15信号通路抑制铁死亡从而减轻脂肪变性供肝再灌注损伤
Shenghe Deng,Huan Cao,Tongxi Li et al.
Shenghe Deng et al.
Ischemia-reperfusion injury (IRI) is a major obstacle in liver transplantation, especially with steatotic donor livers. Dysbiosis of the gut microbiota has been implicated in modulating IRI, and Lachnospiraceae plays a pivotal role in regul...
Ulrika Boulund,Jonathan Thorsen,Urvish Trivedi et al.
Ulrika Boulund et al.
Asthma is a chronic disease affecting millions of children worldwide, and in severe cases requires hospitalization. The etiology of asthma is multifactorial, caused by both genetic and environmental factors. In recent years, the role of the...
Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1 [0.03%]
核梭杆菌通过活化ALPK1诱导结直肠癌细胞高表达免疫抑制分子PD-L1
Coco Duizer,Moniek Salomons,Merel van Gogh et al.
Coco Duizer et al.
Fusobacterium nucleatum is a Gram-negative oncobacterium that is associated with colorectal cancer. The molecular mechanisms utilized by F. nucleatum to promote colorectal tumor development have largely focused on adhesin-mediated binding t...
Targeted modulation of intestinal barrier and mucosal immune-related microbiota attenuates IgA nephropathy progression [0.03%]
靶向调节肠道屏障和黏膜免疫相关菌群可减轻IgA肾病进展
Ran Zhang,Yuyan Tang,Xiangru Feng et al.
Ran Zhang et al.
IgA nephropathy (IgAN) is related to the balance of gut microbiota. However, it is unclear whether changes in the gut microbiota can cause IgAN or attenuate its progression. This study employed IgAN and human microbiota-associated (HMA)-IgA...
Pharmacomicrobiomics: a new field contributing to optimizing drug therapy in Parkinson's disease [0.03%]
药物微生物组学：一个新领域，有助于优化帕金森病的药物治疗
Yi Zhang,Chengjun Mo,Penghui Ai et al.
Yi Zhang et al.
Gut microbiota, which act as a determinant of pharmacokinetics, have long been overlooked. In recent years, a growing body of evidence indicates that the gut microbiota influence drug metabolism and efficacy. Conversely, drugs also exert a ...
Gut microbiota modulation via fecal microbiota transplantation mitigates hyperoxaluria and calcium oxalate crystal depositions induced by high oxalate diet [0.03%]
高草酸盐饮食诱导的高草酸尿症和钙氧氧化物沉积可通过粪菌移植调节肠道菌群改善
Lingyue An,Shujue Li,Zhenglin Chang et al.
Lingyue An et al.
Hyperoxaluria, including primary and secondary hyperoxaluria, is a disorder characterized by increased urinary oxalate excretion and could lead to recurrent calcium oxalate kidney stones, nephrocalcinosis and eventually end stage renal dise...
Geoffrey A Preidis
Geoffrey A Preidis