Long-term yogurt intake and colorectal cancer incidence subclassified by Bifidobacterium abundance in tumor [0.03%]
长期食用酸奶与结直肠癌发病率之间的关系及其在肿瘤中的双歧杆菌丰度分类
Satoko Ugai,Li Liu,Keisuke Kosumi et al.
Satoko Ugai et al.
Evidence suggests a tumor-suppressive effect of the intake of yogurt, which typically contains Bifidobacterium. We hypothesized that long-term yogurt intake might be associated with colorectal cancer incidence differentially by tumor subgro...
Maternal-infant probiotic transmission mitigates early-life stress-induced autism in mice [0.03%]
母体-婴儿益生菌传递可缓解小鼠早期压力引起的自闭症
Li Qing,Xin Qian,Huiyue Zhu et al.
Li Qing et al.
Autism, a disorder influenced by both genetic and environmental factors, presents significant challenges for prevention and treatment. While maternal-infant gut microbiota has been a focus in autism research, preventive strategies targeting...
MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosis [0.03%]
MIIST305救治胃肠急性放射损伤并改善电离辐射致肠道菌群失调
Debmalya Mitra,Gabriel K Armijo,Elizabeth H Ober et al.
Debmalya Mitra et al.
High-dose radiation exposure results in gastrointestinal (GI) acute radiation syndrome identified by the destruction of mucosal layer, intestinal growth barrier dysfunction, and aberrant inflammatory responses. Further, radiation causes gut...
Helicobacter pylori infection induces DNA double-strand breaks through the ACVR1/IRF3/POLD1 signaling axis to drive gastric tumorigenesis [0.03%]
幽门螺杆菌通过ACVR1/IRF3/POLD1信号轴诱导DNA双链断裂驱动胃肿瘤发生
Xinbo Xu,Xiao Fei,Huan Wang et al.
Xinbo Xu et al.
Helicobacter pylori (H. pylori) infection plays a pivotal role in gastric carcinogenesis through inflammation-related mechanisms. Activin A receptor type I (ACVR1), known for encoding the type I receptor for bone morphogenetic proteins (BMP...
Bifidobacterium inhibits the progression of colorectal tumorigenesis in mice through fatty acid isomerization and gut microbiota modulation [0.03%]
乳酸菌通过脂肪酸异构化和肠道微生物群调节抑制小鼠结肠直肠肿瘤发生发展进展
Yang Chen,Huiting Fang,Haiqin Chen et al.
Yang Chen et al.
Colorectal cancer (CRC) represents the third most common cancer worldwide. Consequently, there is an urgent need to identify novel preventive and therapeutic strategies for CRC. This study aimed to screen for beneficial bacteria that have a...
Uncovering de novo polyamine biosynthesis in the gut microbiome and its alteration in inflammatory bowel disease [0.03%]
揭示肠道微生物组从头合成多胺及其在炎症性肠病中的变化
Xinwei Li,Xia Xiao,Shengnan Wang et al.
Xinwei Li et al.
Polyamines are important gut microbial metabolites known to affect host physiology, yet the mechanisms behind their microbial production remain incompletely understood. In this study, we developed a stable isotope-resolved metabolomic (SIRM...
Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation of ILC3: a key driver of intestinal inflammation [0.03%]
黏膜分叉N-聚糖的改变导致肠道菌群失调和ILC3功能下调：肠炎发病的关键驱动因素
Cláudia S Rodrigues,Joana Gaifem,Márcia S Pereira et al.
Cláudia S Rodrigues et al.
The perturbation of the symbiotic relationship between microbes and intestinal immune system contributes to gut inflammation and Inflammatory Bowel Disease (IBD) development. The host mucosa glycans (glycocalyx) creates a major biological i...
Early life gut microbiome and its impact on childhood health and chronic conditions [0.03%]
早期生活肠道微生物组及其对儿童健康和慢性病的影响
Harold Nunez,Pamela A Nieto,Ruben A Mars et al.
Harold Nunez et al.
The development of the gut microbiome is crucial to human health, particularly during the first three years of life. Given its role in immune development, disturbances in the establishment process of the gut microbiome may have long term co...
Post sleeve gastrectomy-enriched gut commensal Clostridia promotes secondary bile acid increase and weight loss [0.03%]
术后胃袖状切除丰富肠道共生菌梭菌促进二次胆汁酸增加和体重减轻
Shaoqian Zhao,Huibin Lin,Wen Li et al.
Shaoqian Zhao et al.
The gut microbiome is altered after bariatric surgery and is associated with weight loss. However, the commensal bacteria involved and the underlying mechanism remain to be determined. We performed shotgun metagenomic sequencing in obese su...
Archaea methanogens are associated with cognitive performance through the shaping of gut microbiota, butyrate and histidine metabolism [0.03%]
古菌甲烷生成菌通过塑造肠道微生物群、丁酸盐和组氨酸代谢与认知表现相关联
Andrea Fumagalli,Anna Castells-Nobau,Dakshat Trivedi et al.
Andrea Fumagalli et al.
The relationship between bacteria, cognitive function and obesity is well established, yet the role of archaeal species remains underexplored. We used shotgun metagenomics and neuropsychological tests to identify microbial species associate...