Consecutive fecal microbiota transplantation for metabolic dysfunction-associated steatotic liver disease: a randomized controlled trial [0.03%]
代谢功能紊乱相关性肝脂肪病的连续粪菌移植疗法：一项随机对照试验
Bas Groenewegen,Merel M Ruissen,Emily Crossette et al.
Bas Groenewegen et al.
The gut microbiota is increasingly considered a contributory factor in metabolic dysfunction-associated steatotic liver disease (MASLD). This double-blind RCT evaluated the effect of three consecutive fecal microbiota transplantations (FMT)...
Randomized Controlled Trial
Gut microbes. 2025 Dec;17(1):2541035. DOI:10.1080/19490976.2025.2541035 2025
Breastfeeding and the milk resistome shape the establishment and transmission of antibiotic resistance genes in the infant gut microbiome [0.03%]
母乳喂养和奶水抗性组影响婴儿肠道菌群中抗生素抗性基因的建立与传播
Zhe Pan,Calum J Walsh,Conor Feehily et al.
Zhe Pan et al.
The infant resistome, the collection of antimicrobial resistance genes (ARGs) of newborns, is critical for gut microbiota establishment. Using metagenomic sequencing data, we analyzed various 1-week and 1-month postpartum samples to study i...
The colonic mucosal virome in inflammatory bowel disease reveals Crassvirales depletion and disease-specific virome features [0.03%]
溃疡性结肠炎黏膜病毒组揭示了新型病毒Crassvirales的消耗和疾病特异性病毒特征
Austin Yan,James Butcher,David R Mack et al.
Austin Yan et al.
The mucosal virome is increasingly recognized for its potential role in shaping intestinal health and disease. Building on previous findings, we analyzed the mucosal virome from 51 individuals, including newly diagnosed treatment naïve par...
Phocaeicola dorei ameliorates progression of steatotic liver disease by regulating bile acid, lipid, inflammation and proliferation [0.03%]
丁酸梭菌通过调节胆汁酸、脂质代谢、炎症及细胞增殖改善脂肪性肝病进展
Jieun Choi,Ye Rin Choi,Min Kyo Jeong et al.
Jieun Choi et al.
Gut microbiota and their metabolites are known to influence the pathogenesis and progression of metabolic dysfunction-associated steatotic liver disease (MASLD). In this study, we investigated the potential beneficial effects of Phocaeicola...
Single cell viral tagging of Faecalibacterium prausnitzii reveals rare bacteriophages omitted by other techniques [0.03%]
单细胞病毒标记法发现Faecalibacterium prausnitzii罕见噬菌体而其他技术则会遗漏这些噬菌体
Danielle E Campbell,Xiaofen Wu,Lindsey R Hall et al.
Danielle E Campbell et al.
The associations of the gut microbiome and virome with human health and disease are increasingly numerous and clear. The mechanistic roles of bacteriophages (phages) in the microbiome, however, are especially unclear, as their cultivation i...
Harnessing Lactiplantibacillus plantarum EP21 and its membrane vesicles to inhibit myopia development [0.03%]
利用肠膜明串珠菌EP21及其外泌体抑制近视发展
Chi-Fong Lin,Yu-An Hsu,Yung-Lan Chou et al.
Chi-Fong Lin et al.
Lactiplantibacillus plantarum, a probiotic that is frequently found in fermented foods, is well known for its numerous health-enhancing properties. This study explored the potential of Lactiplantibacillus plantarum EP21 and its membrane ves...
Contamination-controlled upper gastrointestinal microbiota profiling reveals salivary-duodenal community types linked to opportunistic pathogen carriage and inflammation [0.03%]
无污染控制的上消化道微生物组特征分析揭示了与机会性病原体携带和炎症有关的唾液-十二指肠菌群类型
Nina S Schmidt,Elisabeth Dörner,Daniel Podlesny et al.
Nina S Schmidt et al.
The upper gastrointestinal (uGI) microbiota has been implicated in infectious, metabolic, and immunological conditions, yet remains poorly characterized due to invasive sampling and low microbial biomass. We developed and validated a contam...
Pyruvate-GPR31 axis induces LysoDC dendrite protrusion to M-cell pockets for effective immune responses [0.03%]
丙酮酸-GPR31轴诱导LysoDC树突状突起向M细胞袋以产生有效的免疫反应
Katsuhiro Nakanishi,Takayuki Ajiro,Kaito Yukishima et al.
Katsuhiro Nakanishi et al.
Peyer's patches (PPs) are sites of antigen entry and immunoinduction in the small intestine. In PPs, pathogens are transferred through microfold (M) cells; however, the mechanisms of antigen capture by mononuclear phagocytes beneath M cells...
Diarrheal microbiota-derived extracellular vesicles drive intestinal homeostasis dysfunction via miR-125b/NF-κB-mediated macrophage polarization [0.03%]
腹泻病原体来源的外泌体通过miR-125b/NF-κB介导的巨噬细胞极化驱动肠屏障功能障碍
Mengzhen Song,Wenjun Zhou,Jinping Fan et al.
Mengzhen Song et al.
Gut microbiota-derived extracellular vesicles (EVs) are emerging mediators of microbiota-host crosstalk, but their roles in diarrheal diseases remain poorly understood. Here, we revealed that EVs isolated from diarrheal donors' intestinal m...
Cathelicidin regulates goblet cell mucus secretion and mucus-associated proteins in Citrobacter rodentium-induced colitis [0.03%]
Cathelicidin调节Citrobacter rodentium诱导的结肠炎中的杯状细胞粘液分泌和粘液相关蛋白
Niloofar Mirzadzare,Graham A D Blyth,Rita Hannawayya et al.
Niloofar Mirzadzare et al.
Colonic goblet cells play a crucial role in mucosal defense by secreting Muc2 mucin and other proteins that entrap and expel enteropathogens. However, the role of innate effectors in the gut like cathelicidin peptides in regulating the mucu...