Microbiota transplant therapy in inflammatory bowel disease: advances and mechanistic insights [0.03%]
炎症性肠病中的菌群移植疗法：进展和机制见解
Daphne Moutsoglou,Pavithra Ramakrishnan,Byron P Vaughn
Daphne Moutsoglou
Microbiota transplant therapy is an emerging therapy for inflammatory bowel disease, but factors influencing its efficacy and mechanism remain poorly understood. In this narrative review, we outline key elements affecting therapeutic outcom...
The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential [0.03%]
胃皮肤轴：一个有治疗潜力的双向、微生物驱动的关系
Maira Jimenez-Sanchez,Larissa S Celiberto,Hyungjun Yang et al.
Maira Jimenez-Sanchez et al.
This review explores the emerging term "gut-skin axis" (GSA), describing the bidirectional signaling that occurs between the skin and the gastrointestinal tract under both homeostatic and disease conditions. Central to GSA communication are...
Machine-learning assisted discovery unveils novel interplay between gut microbiota and host metabolic disturbance in diabetic kidney disease [0.03%]
机器学习辅助发现揭示了糖尿病肾病中肠道微生物与宿主代谢紊乱之间的新型相互作用
I-Wen Wu,Yu-Chieh Liao,Tsung-Hsien Tsai et al.
I-Wen Wu et al.
Diabetic kidney disease (DKD) is a serious healthcare dilemma. Nonetheless, the interplay between the functional capacity of gut microbiota and their host remains elusive for DKD. This study aims to elucidate the functional capability of gu...
Alcaligenes faecalis promotes colitis to colorectal cancer transition through IgA+ B cell suppression and vinculin acetylation [0.03%]
阿拉基森粪生菌通过抑制IgA+B细胞和vinculin乙酰化促进结肠炎向结直肠癌的转变
Jing Zheng,Chishun Zhou,Zizheng Li et al.
Jing Zheng et al.
Lymphoid tissue-resident commensal bacteria (LRC), a subtype of gut microbiota essential for inflammation-associated carcinogenesis, predominantly attribute to colorectal cancer(CRC), whereas its role was largely unknown. Herein, we found A...
Prediabetes and type 2 diabetes but not obesity are associated with alterations in bile acid related gut microbe-microbe and gut microbe-host community metabolism [0.03%]
糖尿病前期和二型糖尿病与胆汁酸相关的肠道菌群-菌群以及肠道菌群-宿主的代谢变化有关，而肥胖则无关
Kristina Schlicht,Lea Pape,Nathalie Rohmann et al.
Kristina Schlicht et al.
The interplay between bile acids (BAs) and metabolic diseases has gained importance in recent years, with a variety of studies investigating their relationship with diverging results. Therefore, in the present study we performed a detailed ...
The gut microbiota: an emerging modulator of drug resistance in hepatocellular carcinoma [0.03%]
肠道菌群：肝细胞癌药物耐药性的一个新兴调节因子
Jiali Yao,Beifang Ning,Jin Ding
Jiali Yao
Liver cancer is usually diagnosed at an advanced stage and is the third most common cause of cancer-related death worldwide. In addition to the lack of effective treatment options, resistance to therapeutic drugs is a major clinical challen...
Interbacterial warfare in the human gut: insights from Bacteroidales' perspective [0.03%]
人类肠道内的细菌间战争：从拟杆菌目细菌的角度获得的启示
Kun Jiang,Xinxin Pang,Weixun Li et al.
Kun Jiang et al.
Competition and cooperation are fundamental to the stability and evolution of ecological communities. The human gut microbiota, a dense and complex microbial ecosystem, plays a critical role in the host's health and disease, with competitiv...
Engineering non-pathogenic bacteria for auto-transporter-driven secretion of functional interferon [0.03%]
工程改造无害细菌以实现干扰素的自动传输分泌功能
May Tfilin Samuel,Irina Rostovsky,Alona Kuzmina et al.
May Tfilin Samuel et al.
In recent years, various strategies have been developed to enable the oral administration of protein-based drugs (biologics) with the aim of overcoming the degradation and inactivation of these drugs that can occur as they traverse the gast...
Rhodococcus spp. interacts with human norovirus in clinical samples and impairs its replication on human intestinal enteroids [0.03%]
Rhodococcus属与临床样本中的人诺如病毒相互作用，并阻碍其在人类肠道类器官中的复制
Cristina Santiso-Bellón,Walter Randazzo,Noelia Carmona-Vicente et al.
Cristina Santiso-Bellón et al.
Viral infections, particularly human norovirus (NoV), are a leading cause of diarrheal diseases globally. To better understand NoV susceptibility, it is crucial to investigate both host glycobiology and the influence of the microbiota. Hist...
Extracellular vesicles of Limosilactobacillus fermentum SLAM216 ameliorate skin symptoms of atopic dermatitis by regulating gut microbiome on serotonin metabolism [0.03%]
Limosilactobacillus fermentum SLAM216的胞外囊泡通过调节肠道菌群的血清素代谢改善特应性皮炎的皮肤症状
Hyejin Choi,Min-Jin Kwak,Youbin Choi et al.
Hyejin Choi et al.
Atopic dermatitis (AD) is a globally prevalent chronic inflammatory skin disorder. Its pathogenesis remains incompletely understood, resulting in considerable therapeutic challenges. Recent studies have highlighted the significance of the i...