Gut microbiota in hepatocellular carcinoma immunotherapy: immune microenvironment remodeling and gut microbiota modification [0.03%]
肝细胞癌免疫治疗中的肠道微生物群：免疫微环境重塑和肠道微生物群改造
Mingyao Huang,Quansong Ji,Huiyan Huang et al.
Mingyao Huang et al.
Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality, with limited treatment options at advanced stages. The gut microbiota, a diverse community of microorganisms residing in the gastrointestinal tract, plays a...
The crystal structure of the toxin EspC from enteropathogenic Escherichia coli reveals the mechanism that governs host cell entry and cytotoxicity [0.03%]
产肠毒素大肠杆菌毒素EspC的晶体结构揭示了调控宿主细胞进入和细胞毒性的机制
Akila U Pilapitiya,Lilian Hor,Jing Pan et al.
Akila U Pilapitiya et al.
Enteropathogenic E. coli (EPEC) is a significant cause of diarrhea, leading to high infant mortality rates. A key toxin produced by EPEC is the EspC autotransporter, which is regulated alongside genes from the locus of enterocyte effacement...
Genomic and functional co-diversification imprint African Hominidae microbiomes to signal dietary and lifestyle adaptations [0.03%]
非洲人科微生物组的基因组与功能共同多样化印迹提示饮食和生活方式的适应性变化
Saria Otani,Marie Louise Jespersen,Christian Brinch et al.
Saria Otani et al.
In the diverse landscape of African hominids, the obligate relationship between the host and its microbiome narrates signals of adaptation and co-evolution. Sequencing 546 African hominid metagenomes, including those from indigenous Hadza a...
Elena Kurilovich,Naama Geva-Zatorsky
Elena Kurilovich
The gut microbiome, composed of bacteria, fungi, and viruses, plays a crucial role in maintaining the delicate balance of human health. Emerging evidence suggests that microbiome disruptions can have far-reaching implications, ranging from ...
M28 family peptidase derived from Peribacillus frigoritolerans initiates trained immunity to prevent MRSA via the complosome-phosphatidylcholine axis [0.03%]
源自Peribacillus frigoritolerans的M28家族肽酶通过complosome-卵磷脂轴启动训练免疫以预防MRSA感染
Cheng-Kai Zhou,Zhen-Zhen Liu,Zi-Ran Peng et al.
Cheng-Kai Zhou et al.
Methicillin-resistant Staphylococcus aureus (MRSA) represents a major global health threat due to its resistance to conventional antibiotics. The commensal microbiota maintains a symbiotic relationship with the host, playing essential roles...
Why do babies cry? Exploring the role of the gut microbiota in infantile colic, constipation, and cramps in the KOALA birth cohort study [0.03%]
为什么婴儿会哭泣？在KOALA出生队列研究中探索肠道微生物群在婴儿肠绞痛、便秘和抽筋中的作用
David Barnett,Carel Thijs,Monique Mommers et al.
David Barnett et al.
Gastrointestinal symptoms are common during infancy, including infantile colic. Colic can be loosely defined as prolonged and recurrent crying without obvious cause. The cause indeed remains unclear despite much research. Results on infant ...
Isolation of derivatives from the food-grade probiotic Lactobacillus johnsonii CNCM I-4884 with enhanced anti- Giardia activity [0.03%]
从食品级益生菌Lactobacillus johnsonii CNCM I-4884中分离出具有增强抗Giardia活性的衍生物
Anne-Sophie Boucard,Saulius Kulakauskas,Jana Alazzaz et al.
Anne-Sophie Boucard et al.
Giardiasis, a widespread intestinal parasitosis affecting humans and animals, is a growing concern due to the emergence of drug-resistant strains of G. intestinalis. Probiotics offer a promising alternative for preventing and treating giard...
Anti-interleukin-23 treatment linked to improved Clostridioides difficile infection survival [0.03%]
抗间白细胞介素-23治疗或可提高艰难梭菌感染者生存率
Gregory R Madden,Robert Preissner,Saskia Preissner et al.
Gregory R Madden et al.
Clostridioides difficile is a leading cause of healthcare-associated infection, and an unacceptably high proportion of patients with C. difficile infection die despite conventional antibiotic treatment. Host-directed immunotherapy has been ...
Seasonal variations in circulating endocannabinoidome mediators and gut microbiota composition in humans [0.03%]
人类循环内源性大麻素组介导物和肠道微生物群组成的季节变化
Sophie Castonguay-Paradis,Élisabeth Demers-Potvin,Gabrielle Rochefort et al.
Sophie Castonguay-Paradis et al.
Background: The human gut microbiome-endocannabinoidome axis is crucial for several homeostatic processes, including inflammation and energy metabolism, and is influenced by many endogenous and exogenous factors, such as ...
In vitro competition with Bifidobacterium strains impairs potentially pathogenic growth of Clostridium perfringens on 2'-fucosyllactose [0.03%]
不同双歧杆菌菌株的体外竞争性抑制了2'-岩藻糖基乳糖上潜在的产气荚膜梭状芽胞杆氏菌病原性生长
Aruto Nakajima,Aleksandr A Arzamasov,Mikiyasu Sakanaka et al.
Aruto Nakajima et al.
Fortifying infant formula with human milk oligosaccharides, such as 2'-fucosyllactose (2'-FL), is a global trend. Previous studies have shown the inability of pathogenic gut microbes to utilize 2'-FL. However, the present study demonstrates...