3'-Sialyllactose and B. infantis synergistically alleviate gut inflammation and barrier dysfunction by enriching cross-feeding bacteria for short-chain fatty acid biosynthesis [0.03%]
3'-岩藻糖基乳糖通过富集短链脂肪酸合成的互养细菌与婴儿拟杆菌协同缓解肠道炎症和屏障功能障碍
Mingzhi Yang,Zipeng Jiang,Lutong Zhou et al.
Mingzhi Yang et al.
Ulcerative colitis (UC) poses significant threats to human health and quality of life worldwide, as it is a chronic inflammatory bowel disease. 3'-sialyllactose (3'-SL) is a key functional component of milk oligosaccharides. This study syst...
Raffinose-metabolizing bacteria impair radiation-associated hematopoietic recovery via the bile acid/FXR/NF-κB signaling pathway [0.03%]
半乳糖-Man-葡萄糖三糖代谢菌通过胆汁酸/FXR/NF-κB信号通路损害造血功能的放射性损伤修复
Yang Jiao,Jiawei Ren,Shichang Xie et al.
Yang Jiao et al.
Radiation-associated hematopoietic recovery (RAHR) is critical for mitigating lethal complications of acute radiation syndrome (ARS), yet therapeutic strategies remain limited. Through integrated multi-omics analysis of a total body irradia...
Manabu Nagayama,Lasha Gogokhia,Randy S Longman
Manabu Nagayama
Inflammatory Bowel Disease (IBD) is a spectrum of chronic inflammatory diseases of the intestine that includes subtypes of ulcerative colitis (UC) and Crohn's Disease (CD) and currently has no cure. While IBD results from a complex interpla...
Reutericyclin, a specialized metabolite of Limosilactobacillus reuteri, mitigates risperidone-induced weight gain in mice [0.03%]
乳酸瘤胃球菌雷特氏亚种产生的代谢产物reutericyclin缓解了利培酮诱导的小鼠体重增加现象
Fatima A Aboulalazm,Alexis B Kazen,Orlando deLeon et al.
Fatima A Aboulalazm et al.
The role of xenobiotic disruption of microbiota, corresponding dysbiosis, and potential links to host metabolic diseases are of critical importance. In this study, we used a widely prescribed antipsychotic drug, risperidone, known to influe...
Cross-feeding-based rational design of a probiotic combination of Bacterides xylanisolvens and Clostridium butyricum therapy for metabolic diseases [0.03%]
以互养为基础的合理设计益生菌双歧杆菌木糖异物素溶血素和丁酸梭菌代谢病疗法组合疗法的理性设计
Shanshan Qiao,Tao Wang,Jingzu Sun et al.
Shanshan Qiao et al.
The human gut microbiota has gained interest as an environmental factor that contributes to health or disease. The development of next-generation live biotherapeutic products (LBPs) is a promising strategy to modulate the gut microbiota and...
The impact of gut microbial short-chain fatty acids on colorectal cancer development and prevention [0.03%]
肠道微生物短链脂肪酸对结直肠癌发生及预防的影响
Boobalan Thulasinathan,Kanve N Suvilesh,Sumanas Maram et al.
Boobalan Thulasinathan et al.
Cancer is a long-term illness that involves an imbalance in cellular and immune functions. It can be caused by a range of factors, including exposure to environmental carcinogens, poor diet, infections, and genetic alterations. Maintaining ...
Gut microbiota shift in Ghanaian individuals along the migration axis: the RODAM-Pros cohort [0.03%]
冈比亚人在迁移轴上的肠道微生物群变化：RODAM-Pros队列研究
Barbara J H Verhaar,Eva L van der Linden,Charles F Hayfron-Benjamin et al.
Barbara J H Verhaar et al.
Migration is associated with a substantial change in environmental exposures and health outcomes. We aimed to investigate the shift in gut microbiota composition and the associations with cardiometabolic outcomes in the RODAM-Pros cohort sp...
Best practices for developing microbiome-based disease diagnostic classifiers through machine learning [0.03%]
基于机器学习的微生物组疾病诊断分类器开发的最佳实践
Peikun Li,Min Li,Wei-Hua Chen
Peikun Li
The human gut microbiome, crucial in various diseases, can be utilized to develop diagnostic models through machine learning (ML). The specific tools and parameters used in model construction such as data preprocessing, batch effect removal...
Maternal consumption of urbanized diet compromises early-life health in association with gut microbiota [0.03%]
母亲摄入城市化饮食会通过肠道微生物群影响早产儿健康
Rong Huang,Guicheng Zhou,Jie Cai et al.
Rong Huang et al.
Urbanization has significantly transformed dietary habits worldwide, contributing to a globally increased burden of non-communicable diseases and altered gut microbiota landscape. However, it is often overlooked that the adverse effects of ...
Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19 [0.03%]
整合宏基因组学和代谢组学揭示了恒河猴COVID-19模型中年龄相关的肠道微生物群和代谢物改变
Patrícia Brito Rodrigues,Vinícius de Rezende Rodovalho,Valentin Sencio et al.
Patrícia Brito Rodrigues et al.
Aging is a key contributor of morbidity and mortality during acute viral pneumonia. The potential role of age-associated dysbiosis on disease outcomes is still elusive. In the current study, we used high-resolution shotgun metagenomics and ...